The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Lymphocyte-derived ACh regulates local innate but not adaptive immunity
Abstract
Appropriate control of immune responses is a critical determinant of health. Here, we show that choline acetyltransferase (ChAT) is expressed and ACh is produced by B cells and other immune cells that have an impact on innate immunity. ChAT expression occurs in mucosal-associated lymph tissue, subsequent to microbial colonization, and is reduced by antibiotic treatment. MyD88-dependent Toll-like receptor up-regulates ChAT in a transient manner. Unlike the previously described CD4 + T-cell population that is stimulated by norepinephrine to release ACh, ChAT + B cells release ACh after stimulation with sulfated cholecystokinin but not norepinephrine. ACh-producing B-cells reduce peritoneal neutrophil recruitment during sterile endotoxemia independent of the vagus nerve, without affecting innate immune cell activation. Endothelial cells treated with ACh in vitro reduced endothelial cell adhesion molecule expression in a muscarinic receptor-dependent manner. Despite this ability, ChAT + B cells were unable to suppress effector T-cell function in vivo. Therefore, ACh produced by lymphocytes has specific functions, with ChAT + B cells controlling the local recruitment of neutrophils.
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Cited by
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Forsythe, P., Bienenstock, J., & Kunze, W. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_5 · Cited by 576
Autonomic Nervous System and Immune System Interactions
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Cholinergic modulation of the immune system presents new approaches for treating inflammation
Hoover, D. B. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.05.002 · Cited by 300
Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication
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Metadata
- Authors
- Reardon, C., Duncan, G. S., Brüstle, A., Brenner, D., Tusche, M. W., Olofsson, P. S., Rosas-Ballina, M., Tracey, K. J., & Mak, T. W.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-01-07
- Volume
- 110
- Issue
- 4
- Pages
- 1410-1415
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 209
- References
- 7
- Language
- en
- Update notices
- correction (2013-02-21)
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