Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve
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The immune system in vertebrates senses exogenous and endogenous danger signals by way of complex cellular and humoral processes, and responds with an inflammatory reaction to combat putative attacks. A strong protective immunity is imperative to prevent invasion of pathogens; however, equivalent responses to commensal flora and dietary components in the intestine have to be avoided. The autonomic nervous system plays an important role in sensing luminal contents in the gut by way of hard-wired connections and chemical messengers, such as cholecystokinin (CCK). Here, we report that ingestion of dietary fat stimulates CCK receptors, and leads to attenuation of the inflammatory response by way of the efferent vagus nerve and nicotinic receptors. Vagotomy and administration of antagonists for CCK and nicotinic receptors significantly blunted the inhibitory effect of high-fat enteral nutrition on hemorrhagic shock-induced tumor necrosis factor-α and interleukin-6 release (P < 0.05). Furthermore, the protective effect of high-fat enteral nutrition on inflammation-induced intestinal permeability was abrogated by vagotomy and administration of antagonists for CCK and nicotinic receptors. These data reveal a novel neuroimmunologic pathway, controlled by nutrition, that may help to explain the intestinal hyporesponsiveness to dietary antigens, and shed new light on the functionality of nutrition.
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A high-fat diet activates increased efferent vagus nerve activity, decreases TNF levels, and confers protection against hemorrhagic shock.
“A high-fat diet also activates increased efferent vagus nerve activity, which decreases TNF levels and confers significant protection against hemorrhagic shock (41).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [41]
In rats, fat-induced stimulation of the cholinergic antiinflammatory pathway occurs.
“These clinical antiinflammatory responses may be linked to the fat-induced stimulation of the cholinergic antiinflammatory pathway, as is the case in rats (41).”
From Physiology and immunology of the cholinergic antiinflammatory pathway (2007) · cites this paper as [41]
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Postshock Intervention With High-Lipid Enteral Nutrition Reduces Inflammation and Tissue Damage
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Acute Lung Injury Is Reduced in fat-1 Mice Endogenously Synthesizing n-3 Fatty Acids
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Self-citation
- Authors
- Luyer, M. D., Greve, J. W. M., Hadfoune, M., Jacobs, J. A., Dejong, C. H., & Buurman, W. A.
- Affiliations
- Maastricht University (NL)
- Maastricht University Medical Centre (NL)
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2005-10-10
- Volume
- 202
- Issue
- 8
- Pages
- 1023-1029
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- PMC
- PMC2213207
- OpenAlex
- W2100327483
- Cited by
- 295
- References
- 29
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 11 · 2022: 6 · 2021: 14 · 2020: 11 · 2019: 14 · 2018: 10 · 2017: 15 · 2016: 15 · 2015: 12 · 2014: 17 · 2013: 24 · 2012: 22
- FWCI
- 9.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Experimental Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- ZonMw (907-00-033)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (907-00-033)
- Numico Research
- Topics
- Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- cholecystokinin receptors, vagus nerve, nicotinic acetylcholine receptors, dietary fat, enteral nutrition, inflammation, neuroimmunology, vagotomy, TNF-α, interleukin-6, intestinal permeability, hemorrhagic shock, autonomic nervous system
- MeSH terms
- Animals, Dietary Fats, Enzyme-Linked Immunosorbent Assay, Inflammation, Male, Models, Biological, Receptors, Cholecystokinin, Receptors, Nicotinic, Tumor Necrosis Factor-alpha, Vagus Nerve, Interleukin-6, Cytokines, Rats, Sprague-Dawley, Bacterial Translocation, Rats
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