The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma
Open accessAbstract
Current therapy for glioblastoma multiforme is insufficient, with nearly universal recurrence. Available drug therapies are unsuccessful because they fail to penetrate through the region of the brain containing tumor cells and they fail to kill the cells most responsible for tumor development and therapy resistance, brain cancer stem cells (BCSCs). To address these challenges, we combined two major advances in technology: ( i ) brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery and ( ii ) repurposed compounds, previously used in Food and Drug Administration-approved products, which were identified through library screening to target BCSCs. Using fluorescence imaging and positron emission tomography, we demonstrate that brain-penetrating nanoparticles can be delivered to large intracranial volumes in both rats and pigs. We identified several agents (from Food and Drug Administration-approved products) that potently inhibit proliferation and self-renewal of BCSCs. When loaded into brain-penetrating nanoparticles and administered by convection-enhanced delivery, one of these agents, dithiazanine iodide, significantly increased survival in rats bearing BCSC-derived xenografts. This unique approach to controlled delivery in the brain should have a significant impact on treatment of glioblastoma multiforme and suggests previously undescribed routes for drug and gene delivery to treat other diseases of the central nervous system.
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Markman, J. L., Rekechenetskiy, A., Holler, E., & Ljubimova, J. Y. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.09.019 · Cited by 733
Overcoming the Blood–Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases
Furtado, D., Björnmalm, M., Ayton, S., Bush, A. I., Kempe, K., & Caruso, F. (2018) · Advanced Materials · doi:10.1002/adma.201801362 · Cited by 708
A holistic approach to targeting disease with polymeric nanoparticles
Cheng, C. J., Tietjen, G. T., Saucier-Sawyer, J. K., & Saltzman, W. M. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4503 · Cited by 480
Self-citationDevelopment of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Zhang, W., Mehta, A., Tong, Z., Esser, L., & Voelcker, N. H. (2021) · Advanced Science · doi:10.1002/advs.202003937 · Cited by 430
Engineered nanomedicines with enhanced tumor penetration
Ding, J., Chen, J., Gao, L., Jiang, Z., Zhang, Y., Li, M., Xiao, Q., Lee, S. S., & Chen, X. (2019) · Nano Today · doi:10.1016/j.nantod.2019.100800 · Cited by 420
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Metadata
- Authors
- Zhou, J., Patel, T. R., Sirianni, R. W., Strohbehn, G., Zheng, M.-Q., Duong, N., Schafbauer, T., Huttner, A. J., Huang, Y., Carson, R. E., Zhang, Y., Sullivan, D. J., Piepmeier, J. M., & Saltzman, W. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-07
- Volume
- 110
- Issue
- 29
- Pages
- 11751-11756
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2111498289
- Cited by
- 271
- References
- 7
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhou, J., Patel, T. R., Sirianni, R. W., Strohbehn, G., Zheng, M.-Q., Duong, N., Schafbauer, T., Huttner, A. J., Huang, Y., Carson, R. E., Zhang, Y., Sullivan, D. J., Piepmeier, J. M., & Saltzman, W. M. (2013). Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1304504110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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