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Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
Open accessAbstract
Significance: Nitric oxide from endothelial cells is important for regulating cardiovascular function. Recent data suggest that red blood cells are a source for nitric oxide. We examined the function of red blood cell nitric oxide and the regulation of its formation by the enzyme arginase. We show that red blood cells contain arginase that inhibits nitric oxide export. The function was tested in a heart model subjected to ischemia. The recovery of heart function after ischemia was improved following inhibition of red blood cell arginase. This effect depended on the specific protein producing nitric oxide. The results demonstrate an important function by red blood cells in regulating heart function during ischemia via nitric oxide production under tight control by arginase.
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“The selectivity is partly due to a lack of structural resemblance with purines; this also reduces side effects of purine and pyrimidine metabolism (1041).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1041]
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Metadata
- Authors
- Yang, J., Gonon, A. T., Sjöquist, P.-O., Lundberg, J. O., & Pernow, J.
- Affiliations
- Karolinska University Hospital (SE)
- Divison of Cardiology, Department of Medicine, and
- Karolinska Institutet (SE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-08-26
- Volume
- 110
- Issue
- 37
- Pages
- 15049-15054
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3773799
- OpenAlex
- W2134566930
- Cited by
- 147
- References
- 38
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 7 · 2015: 16 · 2014: 9 · 2013: 2
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- arginase-1, endothelial nitric oxide synthase, erythrocytes, nitric oxide, myocardial ischemia-reperfusion injury, cardioprotection, eNOS knockout mice
- MeSH terms
- Animals, Arginase, Arginine, Biological Transport, Active, Cardiotonic Agents, Enzyme Inhibitors, Erythrocytes, Humans, Mice, Inbred C57BL, Nitrates, Nitric Oxide, Nitrites, Myocardial Reperfusion Injury, Rats, Wistar, Mice, Knockout, Mice, Rats, Nitric Oxide Synthase Type III
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