The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Arginase regulates red blood cell nitric oxide synthase and export of cardioprotective nitric oxide bioactivity
Open accessAbstract
Significance: Nitric oxide from endothelial cells is important for regulating cardiovascular function. Recent data suggest that red blood cells are a source for nitric oxide. We examined the function of red blood cell nitric oxide and the regulation of its formation by the enzyme arginase. We show that red blood cells contain arginase that inhibits nitric oxide export. The function was tested in a heart model subjected to ischemia. The recovery of heart function after ischemia was improved following inhibition of red blood cell arginase. This effect depended on the specific protein producing nitric oxide. The results demonstrate an important function by red blood cells in regulating heart function during ischemia via nitric oxide production under tight control by arginase.
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“The selectivity is partly due to a lack of structural resemblance with purines; this also reduces side effects of purine and pyrimidine metabolism (1041).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1041]
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Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
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“Nitrite may also be involved because it has been shown to be reduced to NO in the ischemic myocardium and to protect against ischemia-reperfusion injury (2, 4).”
BackgroundARGINASE: A CRITICAL REGULATOR OF NITRIC OXIDE SYNTHESIS AND VASCULAR FUNCTION
Durante, W., Johnson, F. K., & Johnson, R. A. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04638.x · Cited by 577 · cited 11×
“After the washing step, the same volume of L-arginine-containing KH buffer was added to the RBCs and gently mixed and incubated with nor-NOHA (0.1–1 mM) at 37 °C for 30 min.”
BackgroundInfluentialRed blood cells express a functional endothelial nitric oxide synthase
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Lundberg, J. O., & Weitzberg, E. (2022) · Cell · doi:10.1016/j.cell.2022.06.010 · Cited by 879
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Horning, K. J., Caito, S. W., Tipps, K. G., Bowman, A. B., & Aschner, M. (2015) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071714-034419 · Cited by 623
Strategies to increase nitric oxide signalling in cardiovascular disease
Lundberg, J. O., Gladwin, M. T., & Weitzberg, E. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4623 · Cited by 576
Self-citationSources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541
Metadata
- Authors
- Yang, J., Gonon, A. T., Sjöquist, P.-O., Lundberg, J. O., & Pernow, J.
- Affiliations
- Karolinska University Hospital (SE)
- Divison of Cardiology, Department of Medicine, and
- Karolinska Institutet (SE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-08-26
- Volume
- 110
- Issue
- 37
- Pages
- 15049-15054
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3773799
- OpenAlex
- W2134566930
- Cited by
- 147
- References
- 38
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 13 · 2017: 10 · 2016: 7 · 2015: 16 · 2014: 9 · 2013: 2
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Keywords
- arginase-1, endothelial nitric oxide synthase, erythrocytes, nitric oxide, myocardial ischemia-reperfusion injury, cardioprotection, eNOS knockout mice
- MeSH terms
- Animals, Arginase, Arginine, Biological Transport, Active, Cardiotonic Agents, Enzyme Inhibitors, Erythrocytes, Humans, Mice, Inbred C57BL, Nitrates, Nitric Oxide, Nitrites, Myocardial Reperfusion Injury, Rats, Wistar, Mice, Knockout, Mice, Rats, Nitric Oxide Synthase Type III
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