The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins
Open accessAbstract
Significance: Mechanical forces, which guide cellular functions, can be sensed and translated into biochemical information at focal adhesions, where cells physically connect to extracellular matrix (ECM) through transmembrane receptor integrins. Our results have identified that different ECM proteins, type 1 collagen (Col I) and fibronectin (FN), can either transmit or shield from mechanical forces when regulating crucial intracellular signaling, focal adhesion kinase (FAK), with their different accessibility to the corresponding integrin receptors. Whereas the integrin α2 binding site in Col I is constitutively accessible, mechanical tension is required to expose the integrin α5 binding motif in FN. This finding should advance our understanding on how cells perceive extracellular mechanical cues through natural surface materials.
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Transmembrane collagen receptors
Leitinger, B. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154013 · Cited by 354
Cited by
FAK in cancer: mechanistic findings and clinical applications
Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381
Integrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
Kubow, K. E., Vukmirovic, R., Zhe, L., Klotzsch, E., Smith, M. L., Gourdon, D., Luna, S., & Vogel, V. (2015) · Nature Communications · doi:10.1038/ncomms9026 · Cited by 344
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate
(2018) · Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.02.002 · Cited by 286
Extracellular matrix directs phenotypic heterogeneity of activated fibroblasts
Avery, D., Govindaraju, P., Jacob, M., Todd, L., Monslow, J., & Puré, E. (2018) · Matrix Biology · doi:10.1016/j.matbio.2017.12.003 · Cited by 206
Metadata
- Authors
- Seong, J., Tajik, A., Sun, J., Guan, J.-L., Humphries, M. J., Craig, S. E., Shekaran, A., García, A. J., Lu, S., Lin, M. Z., Wang, N., & Wang, Y.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-12
- Volume
- 110
- Issue
- 48
- Pages
- 19372-19377
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2087620960
- Cited by
- 190
- References
- 1
- FWCI
- 5.49
- Type
- journal article
- Language
- en
- Open access
- green
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- Seong, J., Tajik, A., Sun, J., Guan, J.-L., Humphries, M. J., Craig, S. E., Shekaran, A., García, A. J., Lu, S., Lin, M. Z., Wang, N., & Wang, Y. (2013). Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1307405110
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