The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix
Open accessAbstract
Despite the crucial role of extracellular matrix (ECM) in directing cell fate in healthy and diseased tissues—particularly in development, wound healing, tissue regeneration and cancer—the mechanisms that direct the assembly and regulate hierarchical architectures of ECM are poorly understood. Collagen I matrix assembly in vivo requires active fibronectin (Fn) fibrillogenesis by cells. Here we exploit Fn-FRET probes as mechanical strain sensors and demonstrate that collagen I fibres preferentially co-localize with more-relaxed Fn fibrils in the ECM of fibroblasts in cell culture. Fibre stretch-assay studies reveal that collagen I’s Fn-binding domain is responsible for the mechano-regulated interaction. Furthermore, we show that Fn-collagen interactions are reciprocal: relaxed Fn fibrils act as multivalent templates for collagen assembly, but once assembled, collagen fibres shield Fn fibres from being stretched by cellular traction forces. Thus, in addition to the well-recognized, force-regulated, cell-matrix interactions, forces also tune the interactions between different structural ECM components.
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Cites
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Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 855
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Xu, S., Xu, H., Wang, W., Li, S., Li, H., Li, T., Zhang, W., Yu, X., & Liu, L. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-2058-1 · Cited by 735
Loebel, C., Mauck, R. L., & Burdick, J. A. (2019) · Nature Materials · doi:10.1038/s41563-019-0307-6 · Cited by 402
Fibronectin: Molecular Structure, Fibrillar Structure and Mechanochemical Signaling
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Nanoparticle protein corona: from structure and function to therapeutic targeting
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Metadata
- Authors
- Kubow, K. E., Vukmirovic, R., Zhe, L., Klotzsch, E., Smith, M. L., Gourdon, D., Luna, S., & Vogel, V.
- Venue
- Nature Communications
- Published
- 2015-08-14
- Volume
- 6
- Issue
- 1
- Pages
- 8026-8026
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2263006505
- Cited by
- 344
- References
- 62
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kubow, K. E., Vukmirovic, R., Zhe, L., Klotzsch, E., Smith, M. L., Gourdon, D., Luna, S., & Vogel, V. (2015). Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix. Nature Communications. https://doi.org/10.1038/ncomms9026
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
