The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines
Open accessAbstract
Significance: The discovery of neutralizing antibodies that block influenza infection by binding to the hemagglutinin (HA) stem domain raised the hope for broadly protective vaccines. These could avoid the need for annual vaccinations and reduce pandemic threats, and the stem subdomain of the trimeric HA ectodomain would be an ideal antigen. However, its production has proven extremely difficult. Here, we describe a simple procedure resulting in high yields of HA stem trimer recognized identically by a panel of neutralizing antibodies as compared with recognition of the full-length HA ectodomain. Cell-free protein synthesis is followed by a simple refolding procedure to produce a rationally mutated stem in which newly exposed protein surfaces are modified and trimerization is induced and covalently stabilized.
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Cites
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Ekiert, D. C., Bhabha, G., Elsliger, M.-A., Friesen, R. H. E., Jongeneelen, M., Throsby, M., Goudsmit, J., & Wilson, I. A. (2009) · Science · doi:10.1126/science.1171491 · Cited by 1,326
Cited by
Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection
Yassine, H. M., Boyington, J. C., McTamney, P. M., Wei, C.-J., Kanekiyo, M., Kong, W.-P., Gallagher, J. R., Wang, L., Zhang, Y., Joyce, M. G., et al. (2015) · Nature Medicine · doi:10.1038/nm.3927 · Cited by 699
Antibodies to combat viral infections: development strategies and progress
Pantaleo, G., Correia, B., Fenwick, C., Joo, V. S., & Perez, L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00495-3 · Cited by 279
Ellebedy, A. H., Krammer, F., Li, G.-M., Miller, M. S., Chiu, C., Wrammert, J., Chang, C. Y., Davis, C. W., McCausland, M., Elbein, R., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414070111 · Cited by 234
Conformational Flexibility in Respiratory Syncytial Virus G Neutralizing Epitopes
Fedechkin, S. O., George, N. L., Nuñez Castrejon, A. M., Dillen, J. R., Kauvar, L. M., & DuBois, R. M. (2020) · Journal of Virology · doi:10.1128/jvi.01879-19 · Cited by 26
Metadata
- Authors
- Lu, Y., Welsh, J. P., & Swartz, J. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-12-16
- Volume
- 111
- Issue
- 1
- Pages
- 125-130
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2076251336
- Cited by
- 216
- References
- 1
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lu, Y., Welsh, J. P., & Swartz, J. R. (2014). Production and stabilization of the trimeric influenza hemagglutinin stem domain for potentially broadly protective influenza vaccines. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1308701110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
