Cited by 235Influenza Virus Research Studiesvaccines and immunoinformatics approachesSARS-CoV-2 and COVID-19 Research

Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans

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Ellebedy, Ali H., Krammer, Florian, Li, Gui-Mei, Miller, Matthew S., Chiu, Christopher, Wrammert, Jens, Chang, Cathy Y., Davis, Carl W. +11 more·2014·Proceedings of the National Academy of Sciences

Abstract

Significance: Vaccination is the most effective means of attaining protection against influenza viruses. However, the constantly evolving nature of influenza viruses enables them to escape preexisting immune surveillance, and thus thwarts public health efforts to control influenza annual epidemics and occasional pandemics. One solution is to elicit antibodies directed against highly conserved epitopes, such as those within the stem region of influenza HA, the principal target of virus-neutralizing antibody responses. This study shows that annual influenza vaccines induce antibody responses that are largely directed against the highly variable HA head region. In contrast, heterologous immunization with HA derived from influenza strains that are currently not circulating in humans (e.g. H5N1) can substantially increase HA stem-specific responses.

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Authors
Ellebedy, A. H., Krammer, F., Li, G.-M., Miller, M. S., Chiu, C., Wrammert, J., Chang, C. Y., Davis, C. W., McCausland, M., Elbein, R., Edupuganti, S., Spearman, P., Andrews, S. F., Wilson, P. C., García-Sastre, A., Mulligan, M. J., Mehta, A. K., Palese, P., & Ahmed, R.
Affiliations
  • Emory University (US)
  • Department of Microbiology,
  • Department of Microbiology and Immunology,
  • Division of Infectious Diseases, Department of Medicine,
  • Department of Pediatrics,
  • University of Chicago (US)
  • HOPE Clinic (US)
Venue
Proceedings of the National Academy of Sciences
Published
2014-08-25
Volume
111
Issue
36
Pages
13133-13138
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1993577147
Cited by
234
References
42
Citations by year
2026: 13 · 2025: 24 · 2024: 12 · 2023: 8 · 2022: 13 · 2021: 24 · 2020: 24 · 2019: 24 · 2018: 30 · 2017: 21 · 2016: 21 · 2015: 19 · 2014: 1
FWCI
15.62
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Georgia Research Alliance
  • Children's Healthcare of Atlanta
  • National Institute for Health and Care Research (NF-SI-0513-10150)
  • Austrian Science Fund (J 3232)
  • National Institutes of Health (HHSN272200800005C, UL1TR000454, P51OD011132)
  • U.S. Public Health Service (HHSN26620070010C)
  • Canadian Institutes of Health Research
  • Medical Research Council (MC_G1001212)
  • National Institute of Allergy and Infectious Diseases (U19AI109946, P01AI097092, HHSN266200700006C, HHSN26620070010C, HHSN272200800005C, U19AI082724, T32AI074492)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
influenza virus, broadly neutralizing antibodies, seasonal influenza vaccination, memory B cells, cross-reactive antibody response, conserved epitopes, heterologous immunization, pandemic influenza preparedness, B cell response
MeSH terms
Adult, Antibody Formation, Antibody Specificity, Cross Reactions, Humans, Immunoglobulin G, Immunologic Memory, Influenza, Human, Influenza Vaccines, Plasma Cells, Vaccination, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype

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