The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth
Open accessAbstract
Significance: As global CO 2 levels rise and fossil fuel abundance decreases, the development of alternative fuels becomes increasingly imperative. Biologically derived fuels, and specifically those from microalgae, are promising sources, but improvements throughout the production process are required to reduce cost. Increasing lipid yields in microalgae without compromising growth has great potential to improve economic feasibility. We report that disrupting lipid catabolism is a practical approach to increase lipid yields in microalgae without affecting growth or biomass. We developed transgenic strains through targeted metabolic engineering that show increased lipid accumulation, biomass, and lipid yields. The target enzyme’s ubiquity suggests that this approach can be applied broadly to improve the economic feasibility of algal biofuels in other groups of microalgae.
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Cites
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Genetic Engineering of Algae for Enhanced Biofuel Production
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Gene silencing in the marine diatom Phaeodactylum tricornutum
De Riso, V., Raniello, R., Maumus, F., Rogato, A., Bowler, C., & Falciatore, A. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp448 · Cited by 305
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Cited by
Genome engineering empowers the diatom Phaeodactylum tricornutum for biotechnology
Daboussi, F., Leduc, S., Maréchal, A., Dubois, G., Guyot, V., Perez-Michaut, C., Amato, A., Falciatore, A., Juillerat, A., Beurdeley, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms4831 · Cited by 455
The lipid biochemistry of eukaryotic algae
Li-Beisson, Y., Thelen, J. J., Fedosejevs, E., & Harwood, J. L. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.01.003 · Cited by 453
Biomass and lipid induction strategies in microalgae for biofuel production and other applications
Alishah Aratboni, H., Rafiei, N., Garcia-Granados, R., Alemzadeh, A., & Morones-Ramírez, J. R. (2019) · Microbial Cell Factories · doi:10.1186/s12934-019-1228-4 · Cited by 437
Minhas, A. K., Hodgson, P., Barrow, C. J., & Adholeya, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00546 · Cited by 445
From first generation biofuels to advanced solar biofuels
Aro, E.-M. (2016) · AMBIO · doi:10.1007/s13280-015-0730-0 · Cited by 369
Metadata
- Authors
- Trentacoste, E. M., Shrestha, R. P., Smith, S. R., Glé, C., Hartmann, A. C., Hildebrand, M., & Gerwick, W. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-18
- Volume
- 110
- Issue
- 49
- Pages
- 19748-19753
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2158927555
- Cited by
- 430
- References
- 8
- FWCI
- 12.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Trentacoste, E. M., Shrestha, R. P., Smith, S. R., Glé, C., Hartmann, A. C., Hildebrand, M., & Gerwick, W. H. (2013). Metabolic engineering of lipid catabolism increases microalgal lipid accumulation without compromising growth. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1309299110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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