The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration
Open accessAbstract
Certain lower vertebrates like zebrafish activate proliferation of spared cardiomyocytes after cardiac injury to regenerate lost heart muscle. Here, we used translating ribosome affinity purification to profile translating RNAs in zebrafish cardiomyocytes during heart regeneration. We identified dynamic induction of several Jak1/Stat3 pathway members following trauma, events accompanied by cytokine production. Transgenic Stat3 inhibition in cardiomyocytes restricted injury-induced proliferation and regeneration, but did not reduce cardiogenesis during animal growth. The secreted protein Rln3a was induced in a Stat3-dependent manner by injury, and exogenous Rln3 delivery during Stat3 inhibition stimulated cardiomyocyte proliferation. Our results identify an injury-specific cardiomyocyte program essential for heart regeneration.
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Cites
limma: Linear Models for Microarray Data
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Mammalian heart renewal by pre-existing cardiomyocytes
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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation
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A translational profiling approach for the molecular characterization of CNS cell types
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Functional screening identifies miRNAs inducing cardiac regeneration
Eulalio, A., Mano, M., Ferro, M. D., Zentilin, L., Sinagra, G., Zacchigna, S., & Giacca, M. (2012) · Nature · doi:10.1038/nature11739 · Cited by 1,029
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Application of a translational profiling approach for the comparative analysis of CNS cell types
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STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration
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Modulation of tissue repair by regeneration enhancer elements
Kang, J., Hu, J., Karra, R., Dickson, A. L., Tornini, V. A., Nachtrab, G., Gemberling, M., Goldman, J. A., Black, B. L., & Poss, K. D. (2016) · Nature · doi:10.1038/nature17644 · Cited by 316
Self-citationGemberling, M., Karra, R., Dickson, A. L., & Poss, K. D. (2015) · eLife · doi:10.7554/elife.05871 · Cited by 302
Self-citationZebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs
Hui, S. P., Sheng, D. Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., & Kikuchi, K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.010 · Cited by 264
Self-citationZhu, H., Liu, X., Ding, Y., Tan, K., Ni, W., Ouyang, W., Tang, J., Ding, X., Zhao, J., Hao, Y., et al. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02675-1 · Cited by 19
Rao, A., Lyu, B., Jahan, I., Lubertozzi, A., Zhou, G., Tedeschi, F., Jankowsky, E., Kang, J., Carstens, B., Poss, K. D., et al. (2023) · Development · doi:10.1242/dev.201376 · Cited by 13
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Metadata
- Authors
- Fang, Y., Gupta, V., Karra, R., Holdway, J. E., Kikuchi, K., & Poss, K. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-07-30
- Volume
- 110
- Issue
- 33
- Pages
- 13416-13421
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2115577728
- Cited by
- 193
- References
- 8
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Fang, Y., Gupta, V., Karra, R., Holdway, J. E., Kikuchi, K., & Poss, K. D. (2013). Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1309810110
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