The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish
Open accessAbstract
Heart regeneration is limited in adult mammals but occurs naturally in adult zebrafish through the activation of cardiomyocyte division. Several components of the cardiac injury microenvironment have been identified, yet no factor on its own is known to stimulate overt myocardial hyperplasia in a mature, uninjured animal. In this study, we find evidence that Neuregulin1 (Nrg1), previously shown to have mitogenic effects on mammalian cardiomyocytes, is sharply induced in perivascular cells after injury to the adult zebrafish heart. Inhibition of Erbb2, an Nrg1 co-receptor, disrupts cardiomyocyte proliferation in response to injury, whereas myocardial Nrg1 overexpression enhances this proliferation. In uninjured zebrafish, the reactivation of Nrg1 expression induces cardiomyocyte dedifferentiation, overt muscle hyperplasia, epicardial activation, increased vascularization, and causes cardiomegaly through persistent addition of wall myocardium. Our findings identify Nrg1 as a potent, induced mitogen for the endogenous adult heart regeneration program.
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Cites
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Self-citationHuman embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts
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Cited by
Modulation of tissue repair by regeneration enhancer elements
Kang, J., Hu, J., Karra, R., Dickson, A. L., Tornini, V. A., Nachtrab, G., Gemberling, M., Goldman, J. A., Black, B. L., & Poss, K. D. (2016) · Nature · doi:10.1038/nature17644 · Cited by 316
Self-citationCahill, T. J., Choudhury, R. P., & Riley, P. R. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.106 · Cited by 312
Mechanisms of Cardiac Regeneration
Uygur, A., & Lee, R. T. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.01.018 · Cited by 286
Zebrafish Regulatory T Cells Mediate Organ-Specific Regenerative Programs
Hui, S. P., Sheng, D. Z., Sugimoto, K., Gonzalez-Rajal, A., Nakagawa, S., Hesselson, D., & Kikuchi, K. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.11.010 · Cited by 264
Molecular Mechanisms of Cardiac Remodeling and Regeneration in Physical Exercise
Schüttler, D., Clauss, S., Weckbach, L. T., & Brunner, S. (2019) · Cells · doi:10.3390/cells8101128 · Cited by 117
Metadata
- Authors
- Gemberling, M., Karra, R., Dickson, A. L., & Poss, K. D.
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2015-04-01
- Volume
- 4
- ISSN
- 2050-084X (ISSN-L)
- OpenAlex
- W2030890903
- Cited by
- 302
- References
- 49
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gemberling, M., Karra, R., Dickson, A. L., & Poss, K. D. (2015). Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish. eLife. https://doi.org/10.7554/elife.05871
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