Development of a histone deacetylase 6 inhibitor and its biological effects

HDAC6 is a microtubule-associated deacetylase

Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., & Yao, T.-P. (2002) · Nature · doi:10.1038/417455a · Cited by 2,403 · see citing works

The Deacetylase HDAC6 Regulates Aggresome Formation and Cell Viability in Response to Misfolded Protein Stress

Kawaguchi, Y., Kovacs, J. J., McLaurin, A. C., Vance, J. M., Ito, A., & Yao, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00939-5 · Cited by 1,529 · see citing works

Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

Marks, P. A., & Breslow, R. (2007) · Nature Biotechnology · doi:10.1038/nbt1272 · Cited by 1,198 · see citing works

HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

Kovacs, J. J., Murphy, P. J. M., Gaillard, S., Zhao, X., Wu, J.-T., Nicchitta, C. V., Yoshida, M., Toft, D. O., Pratt, W. B., & Yao, T.-P. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.04.021 · Cited by 1,153 · see citing works

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sarkar, S., Davies, J. E., Huang, Z., Tunnacliffe, A., & Rubinsztein, D. C. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609532200 · Cited by 1,142 · see citing works

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

Haggarty, S. J., Koeller, K. M., Wong, J. C., Grozinger, C. M., & Schreiber, S. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0430973100 · Cited by 1,066 · see citing works

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

Butler, K. V., Kalin, J., Brochier, C., Vistoli, G., Langley, B., & Kozikowski, A. P. (2010) · Journal of the American Chemical Society · doi:10.1021/ja102758v · Cited by 801 · see citing works

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

Lee, J., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.405 · Cited by 756 · see citing works

HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin

Zhang, X. M., Yuan, Z., Zhang, Y., Yong, S., Salas-Burgos, A., Koomen, J. M., Olashaw, N., Parsons, J. T., Yang, X., Dent, S., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.05.033 · Cited by 731 · see citing works

Chemical phylogenetics of histone deacetylases

Bradner, J. E., West, N., Grachan, M. L., Greenberg, E. F., Haggarty, S. J., Warnow, T., & Mazitschek, R. (2010) · Nature Chemical Biology · doi:10.1038/nchembio.313 · Cited by 720 · see citing works

Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma

Santo, L., Hideshima, T., Kung, A. L., Tseng, J.-C., Tamang, D., Yang, M., Jarpe, M., van Duzer, J. H., Mazitschek, R., Ogier, W. C., et al. (2012) · Blood · doi:10.1182/blood-2011-10-387365 · Cited by 616 · see citing works

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo.

Butler, L. M., Agus, D. B., Scher, H. I., Higgins, B., Rose, A., Cordon‐Cardo, C., Thaler, H. T., Rifkind, R. A., Marks, P. A., & Richon, V. M. (2000) · PubMed · Cited by 613 · see citing works

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

Hideshima, T., Bradner, J. E., Wong, J. Y. Y., Chauhan, D., Richardson, P. G. G., Schreiber, S. L., & Anderson, K. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503221102 · Cited by 598 · see citing works

HDAC6: a key regulator of cytoskeleton, cell migration and cell–cell interactions

Valenzuela-Fernández, A., Cabrero, J. R., Serrador, J. M., & Sánchez‐Madrid, F. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.04.003 · Cited by 500 · see citing works

The deacetylase HDAC6 is a novel critical component of stress granules involved in the stress responsePreprint

Kwon, S., Zhang, Y., & Matthias, P. (2007) · Genes & Development · doi:10.1101/gad.461107 · Cited by 402 · see citing works

HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregatesPreprint

Boyault, C., Zhang, Y., Fritah, S., Caron, C., Gilquin, B., Kwon, S. H., Garrido, C., Yao, T., Vourc’h, C., Matthias, P., et al. (2007) · Genes & Development · doi:10.1101/gad.436407 · Cited by 370 · see citing works

Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair

Lee, J.-H., Choy, M. L., Ngo, L., Foster, S. S., & Marks, P. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008522107 · Cited by 364 · see citing works

Histone deacetylase 6 plays a role as a distinct regulator of diverse cellular processes

Li, Y., Shin, D., & Kwon, S. H. (2012) · FEBS Journal · doi:10.1111/febs.12079 · Cited by 346 · see citing works

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

Parmigiani, R. B., Xu, W., Venta-Perez, G., Erdjument‐Bromage, H., Yaneva, M., Tempst, P., & Marks, P. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803749105 · Cited by 325 · see citing works

Transient Poly(ADP-ribosyl)ation of Nuclear Proteins and Role of Poly(ADP-ribose) Polymerase in the Early Stages of Apoptosis

Simbulan-Rosenthal, C. M., Rosenthal, D. S., Iyer, S., Boulares, A. H., & Smulson, M. E. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13703 · Cited by 277 · see citing works

Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents

Namdar, M., Perez, G., Ngo, L., & Marks, P. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1013754107 · Cited by 207 · see citing works

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

Bergman, J. A., Woan, K. V., Perez-Villarroel, P., Villagra, A., Sotomayor, E. M., & Kozikowski, A. P. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301098e · Cited by 200 · see citing works

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

Marks, P. A. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.008 · Cited by 189 · see citing works

Development and therapeutic impact of HDAC6-selective inhibitors

Dallavalle, S., Pisano, C., & Zunino, F. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.06.014 · Cited by 137 · see citing works

Structural Origin of Selectivity in Class II-Selective Histone Deacetylase Inhibitors

Estiu, G. L., Greenberg, E. F., Harrison, C. B., Kwiatkowski, N. P., Mazitschek, R., Bradner, J. E., & Wiest, O. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm7015254 · Cited by 110 · see citing works

A Novel Class of Small Molecule Inhibitors of HDAC6

Inks, E. S., Josey, B. J., Jesinkey, S. R., & Chou, C. J. (2011) · ACS Chemical Biology · doi:10.1021/cb200134p · Cited by 103 · see citing works

Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells

Wang, L., Xiang, S., Williams, K. A., Dong, H., Bai, W., Nicosia, S. V., Khochbin, S., Bepler, G., & Zhang, X. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044265 · Cited by 85 · see citing works

Novel HDAC6 isoform selective chiral small molecule histone deacetylase inhibitors

Smil, D. V., Manku, S., Chantigny, Y., Leit, S. M., Wahhab, A., Yan, T. P., Fournel, M., Maroun, C. R., Li, Z., Lemieux, A., et al. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.12.045 · Cited by 83 · see citing works

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

Falkenberg, K. J., & Johnstone, R. W. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4360 · Cited by 1,564 · see citing works

HDACs and HDAC Inhibitors in Cancer Development and TherapyPreprint

Li, Y., & Seto, E. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026831 · Cited by 1,309 · see citing works

Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials

Lin, A., Giuliano, C. J., Palladino, A. C., John, K. M., Abramowicz, C., Yuan, M. L., Sausville, E. L., Lukow, D. A., Liu, L., Chait, A. R., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw8412 · Cited by 747 · see citing works

Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

Hai, Y., & Christianson, D. W. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2134 · Cited by 521 · see citing works

Inside HDACs with more selective HDAC inhibitors

Roche, J., & Bertrand, P. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.05.047 · Cited by 323 · see citing works

Targeting Metalloenzymes for Therapeutic Intervention

Chen, A. Y., Adamek, R. N., Dick, B. L., Credille, C. V., Morrison, C. N., & Cohen, S. M. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00201 · Cited by 277 · see citing works

HDAC6 as privileged target in drug discovery: A perspective

Pulya, S., Amin, S. A., Adhikari, N., Biswas, S., Jha, T., & Ghosh, B. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105274 · Cited by 265 · see citing works

Targeting histone deacetylases for cancer therapy: Trends and challenges

Liang, T., Wang, F., Elhassan, R. M., Cheng, Y., Tang, X., Chen, W., Fang, H., & Hou, X. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.02.007 · Cited by 222 · see citing works

Histone Deacetylase 6 in Health and Disease

Seidel, C., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2015) · Epigenomics · doi:10.2217/epi.14.69 · Cited by 216 · see citing works

Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors

Porter, N. J., Mahendran, A., Breslow, R., & Christianson, D. W. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1718823114 · Cited by 190 · see citing works

A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity

Zhang, X., Qin-Ma, Wu, H.-P., Khamis, M. Y., Li, Y., Ma, L., & Liu, H. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01782 · Cited by 160 · see citing works

Recent advances in the discovery of potent and selective HDAC6 inhibitors

Wang, X.-X., Wan, R.-Z., & Liu, Z.-P. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.10.040 · Cited by 152 · see citing works

Next-generation of selective histone deacetylase inhibitors

Yang, F., Zhao, N., Ge, D., & Chen, Y. (2019) · RSC Advances · doi:10.1039/c9ra02985k · Cited by 144 · see citing works

Drugging the HDAC6–HSP90 interplay in malignant cells

Krämer, O. H., Mahboobi, S., & Sellmer, A. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.001 · Cited by 133 · see citing works

Strategies To Design Selective Histone Deacetylase Inhibitors

Melesina, J., Simoben, C. V., Praetorius, L., Bülbül, E. F., Robaa, D., & Sippl, W. (2021) · ChemMedChem · doi:10.1002/cmdc.202000934 · Cited by 118 · see citing works

Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

Porter, N. J., Osko, J. D., Diedrich, D., Kurz, T., Hooker, J. M., Hansen, F. K., & Christianson, D. W. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01013 · Cited by 111 · see citing works

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer

Yang, Z., Wang, T., Wang, F., Niu, T., Liu, Z., Chen, X. L., Long, C., Tang, M., Cao, D., Wang, X., et al. (2015) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01342 · Cited by 111 · see citing works

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

Vögerl, K., Ong, N., Senger, J., Herp, D., Schmidtkunz, K., Marek, M., Müller, M., Bartel, K., Shaik, T. B., Porter, N. J., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01090 · Cited by 104 · see citing works

A patent review of IDO1 inhibitors for cancer

Cheong, J. E., Ekkati, A. R., & Sun, L. (2018) · Expert Opinion on Therapeutic Patents · doi:10.1080/13543776.2018.1441290 · Cited by 104 · see citing works

Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules

Husain, M., & Cheung, C. (2014) · Journal of Virology · doi:10.1128/jvi.00727-14 · Cited by 100 · see citing works

HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors

Sangwan, R., Rajan, R., & Mandal, P. K. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.073 · Cited by 97 · see citing works

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated

Géraldy, M. N. E., Morgen, M., Sehr, P. A., Steimbach, R. R., Moi, D., Ridinger, J., Oehme, I., Witt, O., Malz, M., Nogueira, M. S., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01936 · Cited by 96 · see citing works

The Role of KLF2 in the Regulation of Atherosclerosis Development and Potential Use of KLF2-Targeted Therapy

Dabravolski, S. A., Sukhorukov, V. N., Kalmykov, V. A., Grechko, A. V., Shakhpazyan, N. K., & Orekhov, A. N. (2022) · Biomedicines · doi:10.3390/biomedicines10020254 · Cited by 96 · see citing works

HDAC6: A unique HDAC family member as a cancer target

Kaur, S., Rajoria, P., & Chopra, M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00704-6 · Cited by 95 · see citing works

How Does Chirality Determine the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers Based on Molecular Dynamics

Zhang, Y., Ying, J. B., Hong, J. J., Li, F., Fu, T. T., Yang, F. Y., Zheng, G. X., Yao, X., Lou, Y., Qiu, Y., et al. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00729 · Cited by 94 · see citing works

Epigenetic modulators as therapeutic targets in prostate cancer

Graça, I. C. R., Pereira-Silva, E., Henrique, R., Packham, G., Crabb, S. J., & Jerónimo, C. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0264-8 · Cited by 88 · see citing works

Squaramides as Bioisosteres in Contemporary Drug Design

Agnew‐Francis, K. A., & Williams, C. M. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00416 · Cited by 86 · see citing works

Small Molecules Targeting HATs, HDACs, and BRDs in Cancer Therapy

Wu, D., Qiu, Y., Jiao, Y., Qiu, Z., & Liu, D. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.560487 · Cited by 81 · see citing works

A quorum-sensing signal promotes host tolerance training through HDAC1-mediated epigenetic reprogramming

Bandyopadhaya, A., Tsurumi, A., Maura, D., Jeffrey, K. L., & Rahme, L. G. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.174 · Cited by 79 · see citing works

Photoorganocatalytic One‐Pot Synthesis of Hydroxamic Acids from Aldehydes

Papadopoulos, G. N., & Kokotos, C. G. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201600333 · Cited by 78 · see citing works

HDAC Family Members Intertwined in the Regulation of Autophagy: A Druggable Vulnerability in Aggressive Tumor Entities

Koeneke, E., Witt, O., & Oehme, I. (2015) · Cells · doi:10.3390/cells4020135 · Cited by 74 · see citing works

Therapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro

Oh, B. R., Suh, D., Bae, D., Ha, N., Choi, Y. I., Yoo, H. J., Park, J. K., Lee, E. Y., Lee, E. B., & Song, Y. W. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1357-2 · Cited by 72 · see citing works

Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease

Rabal, O., Sánchez-Arias, J. A., Cuadrado‐Tejedor, M., de Miguel, I., Pérez-González, M., García, C., Ugarte, A., de Mendoza, A. E., Sáez, E., Espelosin, M., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.03.005 · Cited by 71 · see citing works

Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6

Porter, N. J., Wagner, F. F., & Christianson, D. W. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00367 · Cited by 64 · see citing works

Phase separation of phospho-HDAC6 drives aberrant chromatin architecture in triple-negative breast cancer

Lu, B., Qiu, R., Wei, J., Wang, L., Zhang, Q., Li, M., Zhan, X., Chen, J., Hsieh, I.-Y., Yang, C., et al. (2024) · Nature Cancer · doi:10.1038/s43018-024-00816-y · Cited by 62 · see citing works

4-Hydroxybenzoic acid derivatives as HDAC6-specific inhibitors modulating microtubular structure and HSP90α chaperone activity against prostate cancer

Seidel, C., Schnekenburger, M., Mazumder, A., Teiten, M.-H., Kirsch, G., Dicato, M. A., & Diederich, M. F. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.11.005 · Cited by 62 · see citing works

Identification of a Novel Aminotetralin Class of HDAC6 and HDAC8 Selective Inhibitors

Tang, G., Wong, J. C., Zhang, W., Wang, Z., Zhang, N., Peng, Z., Zhang, Z., Rong, Y., Li, S., Zhang, M., et al. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm5008962 · Cited by 62 · see citing works

Design, synthesis and evaluate of novel dual FGFR1 and HDAC inhibitors bearing an indazole scaffold

Liu, J., Qian, C., Zhu, Y., Cai, J., He, Y., Li, J., Wang, T., Zhu, H., Li, Z., Li, W., et al. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.12.041 · Cited by 61 · see citing works

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma

Phimmachanh, M., Han, J. Z. R., O’Donnell, Y. E. I., Latham, S. L., & Croucher, D. R. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.578770 · Cited by 61 · see citing works

Epigenetic modifications as regulatory elements of autophagy in cancer

Sui, X., Zhu, J., Zhou, J., Wang, X., Li, D., Han, W., Fang, Y., & Pan, H. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.02.009 · Cited by 57 · see citing works

Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway

Shi, X., Liu, Y., Zhang, D., & Xiao, D. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116613 · Cited by 57 · see citing works

Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation

Vergani, B., Sandrone, G., Marchini, M., Ripamonti, C., Cellupica, E., Galbiati, E., Caprini, G., Pavich, G., Porro, G., Rocchio, I., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01194 · Cited by 56 · see citing works

Synthesis and applications of benzohydroxamic acid-based histone deacetylase inhibitors

Vreese, R. D., & D’hooghe, M. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.04.013 · Cited by 55 · see citing works

HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions

Osseni, A., Ravel‐Chapuis, A., Thomas, J.-L., Gache, V., Schaeffer, L., & Jasmin, B. J. (2020) · The Journal of Cell Biology · doi:10.1083/jcb.201901099 · Cited by 55 · see citing works

Novel 2, 5-diketopiperazine derivatives as potent selective histone deacetylase 6 inhibitors: Rational design, synthesis and antiproliferative activity

Chen, X., Chen, X., Steimbach, R. R., Wu, T., Li, H., Dan, W., Shi, P., Cao, C., Li, D., Miller, A. K., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111950 · Cited by 53 · see citing works

Rational design and diversity-oriented synthesis of peptoid-based selective HDAC6 inhibitors

Diedrich, D., Hamacher, A., Gertzen, C. G. W., Avelar, L. A. A., Reiß, G. J., Kurz, T., Gohlke, H., Kassack, M. U., & Hansen, F. K. (2016) · Chemical Communications · doi:10.1039/c5cc10301k · Cited by 52 · see citing works

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

Stenzel, K., Hamacher, A., Hansen, F. K., Gertzen, C. G. W., Senger, J., Marquardt, V., Marek, L., Marek, M., Romier, C., Remke, M., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01538 · Cited by 51 · see citing works

The HDAC6 inhibitor C1A modulates autophagy substrates in diverse cancer cells and induces cell death

Kaliszczak, M. A., van Hechanova, E., Li, Y., Al-Sadah, H. A., Parzych, K., Auner, H. W., & Aboagye, E. O. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0232-5 · Cited by 51 · see citing works

The emerging potential of autophagy-based therapies in the treatment of cystic fibrosis lung infections

Junkins, R. D., McCormick, C., & Lin, T. (2014) · Autophagy · doi:10.4161/auto.27750 · Cited by 51 · see citing works

HDAC 1 and 6 modulate cell invasion and migration in clear cell renal cell carcinoma

Ramakrishnan, S., Ku, S., Ciamporcero, E. S., Miles, K. M., Attwood, K. M., Chintala, S., Shen, L., Ellis, L., Sotomayor, P. C., Swetzig, W. M., et al. (2016) · BMC Cancer · doi:10.1186/s12885-016-2604-7 · Cited by 50 · see citing works

Anti-cancer effects of naturally derived compounds targeting histone deacetylase 6-related pathways

Lernoux, M., Schnekenburger, M., Dicato, M. A., & Diederich, M. F. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.004 · Cited by 49 · see citing works

Inhibition of glioblastoma cell proliferation, invasion, and mechanism of action of a novel hydroxamic acid hybrid molecule

Zhang, I., Beus, M., Stochaj, U., Le, P. U., Zorc, B., Rajić, Z., Petrecca, K., & Maysinger, D. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0103-0 · Cited by 47 · see citing works

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells

Rosik, L., Niegisch, G., Fischer, U., Jung, M., Schulz, W. A., & Hoffmann, M. J. (2014) · Cancer Biology & Therapy · doi:10.4161/cbt.28469 · Cited by 47 · see citing works

Dual inhibitors of HDAC and other epigenetic regulators: A novel strategy for cancer treatment

Shirbhate, E., Singh, V. P., Jahoriya, V., Mishra, A., Veerasamy, R., Tiwari, A. K., & Rajak, H. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115938 · Cited by 45 · see citing works

Small molecules targeting HDAC6 for cancer treatment: Current progress and novel strategies

Huang, Z., Li, L., Cheng, B., & Li, D. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117218 · Cited by 45 · see citing works

Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents

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Design and Synthesis of Orally Bioavailable Aminopyrrolidinone Histone Deacetylase 6 Inhibitors

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Design, synthesis and biological evaluation of novel hydroxamic acid based histone deacetylase 6 selective inhibitors bearing phenylpyrazol scaffold as surface recognition motif

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The principal pivot : new potent HDAC6 selective inhibitors with a non-hydroxamic acid zinc binding group for applications beyond oncology

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Preferential HDAC6 inhibitors derived from HPOB exhibit synergistic antileukemia activity in combination with decitabine

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