The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing
Open accessAbstract
Significance: Genome-wide hypomethylation is frequently observed in cancers. In this study, we showed that genome-wide hypomethylation analysis in plasma using shotgun massively parallel bisulfite sequencing is a powerful general approach for the detection of multiple types of cancers. This approach is particularly attractive because high sensitivity and specificity can be achieved using low sequence depth, which is practical diagnostically. This approach can also be used for monitoring patients following treatment. The same sequencing data can be further used for detecting cancer-associated copy number aberrations at no additional costs. One could thus combine plasma hypomethylation and copy number analyses in a synergistic manner for further enhancing detection sensitivity or specificity.
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Self-citationCell-free nucleic acids as biomarkers in cancer patients
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Integrating liquid biopsies into the management of cancer
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Current and future perspectives of liquid biopsies in genomics-driven oncology
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Genome-wide cell-free DNA fragmentation in patients with cancer
Cristiano, S., Leal, A., Phallen, J., Fiksel, J., Adleff, V., Bruhm, D. C., Jensen, S. Ø., Medina, J. E., Hruban, C., White, J. R., et al. (2019) · Nature · doi:10.1038/s41586-019-1272-6 · Cited by 1,476
Metadata
- Authors
- Chan, K. C. A., Jiang, P., Chan, C. W. M., Sun, K., Wong, J., Hui, E. P., Chan, S. L., Chan, W. C., Hui, D. S. C., Ng, S. S. M., Chan, H. L. Y., Wong, C. S. C., Ma, B. B. Y., Chan, A. T. C., Lai, P. B. S., Sun, H., Chiu, R. W. K., & Lo, Y. M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-04
- Volume
- 110
- Issue
- 47
- Pages
- 18761-18768
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2089470652
- Cited by
- 447
- References
- 31
- FWCI
- 7.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chan, K. C. A., Jiang, P., Chan, C. W. M., Sun, K., Wong, J., Hui, E. P., Chan, S. L., Chan, W. C., Hui, D. S. C., Ng, S. S. M., Chan, H. L. Y., Wong, C. S. C., Ma, B. B. Y., Chan, A. T. C., Lai, P. B. S., Sun, H., Chiu, R. W. K., & Lo, Y. M. D. (2013). Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1313995110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
