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BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis
Open accessAbstract
Significance: Cellulose is the most abundant biopolymer on Earth, primarily formed by vascular plants, but also by some bacteria. Bacterial extracellular polysaccharides, such as cellulose and alginate, are an important component of biofilms, which are multicellular, usually sessile, aggregates of bacteria. Biofilms exhibit a greater resistance to antimicrobial treatments compared with isolated bacteria and thus are a particular concern to human health. Cellulose synthases synthesize cellulose by polymerizing UDP-activated glucose and transport the growing polymer across the cell membrane during its synthesis. Despite numerous attempts, reconstituting cellulose synthesis in vitro from purified components has been unsuccessful. Here we present the complete reconstitution of bacterial cellulose synthesis from components from Rhodobacter sphaeroides, thereby establishing an experimental basis for cellulose and biofilm research.
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Cited by
Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
“The BcsA and BcsB proteins form the two subunits of the cellulose synthase complexthatislocatedwithinthemembraneandconvertsUDP-glucose to cellulose (Zogaj et al. 2001; Omadjela et al. 2013).”
BackgroundBacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions
Römling, U., & Galperin, M. Y. (2015) · Trends in Microbiology · doi:10.1016/j.tim.2015.05.005 · Cited by 573
A Molecular Description of Cellulose Biosynthesis
McNamara, J. T., Morgan, J. L. W., & Zimmer, J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-033930 · Cited by 382
Self-citationBiofilm formation by enteric pathogens and its role in plant colonization and persistence
Yaron, S., & Römling, U. (2014) · Microbial Biotechnology · doi:10.1111/1751-7915.12186 · Cited by 277
Metadata
- Authors
- Omadjela, O., Narahari, A., Strumillo, J., Mélida, H., Mazur, O., Bulone, V., & Zimmer, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-14
- Volume
- 110
- Issue
- 44
- Pages
- 17856-17861
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2112289062
- Cited by
- 273
- References
- 0
- FWCI
- 29.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Omadjela, O., Narahari, A., Strumillo, J., Mélida, H., Mazur, O., Bulone, V., & Zimmer, J. (2013). BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1314063110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
