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Cited by 573

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions

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Römling, Ute, Galperin, Michael Y.·2015·Trends in Microbiology
DOI 10.1016/j.tim.2015.05.005
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Abstract

Summary Recent studies of bacterial cellulose biosynthesis, including structural characterization of a functional cellulose synthase complex, provided the first mechanistic insight into this fascinating process. In most studied bacteria, just two subunits, BcsA and BcsB, are necessary and sufficient for the formation of the polysaccharide chain in vitro. Other subunits – which differ among various taxa – affect the enzymatic activity and product yield in vivo by modulating expression of biosynthesis apparatus, export of the nascent β-D-glucan polymer to the cell surface, and the organization of cellulose fibers into a higher-order structure. These auxiliary subunits play key roles in determining the quantity and structure of the resulting biofilm, which is particularly important for interactions of bacteria with higher organisms that lead to rhizosphere colonization and modulate virulence of cellulose-producing bacterial pathogens inside and outside of host cells. Here we review the organization of four principal types of cellulose synthase operons found in various bacterial genomes, identify additional bcs genes that encode likely components of the cellulose biosynthesis and secretion machinery, and propose a unified nomenclature for these genes and subunits. We also discuss the role of cellulose as a key component of biofilms formed by a variety of free-living and pathogenic bacteria and, for the latter, in the choice between acute infection and persistence in the host.

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Metadata

Authors
Römling, U., & Galperin, M. Y.
Venue
Trends in Microbiology
Publisher
Elsevier BV
Published
2015-09
Volume
23
Issue
9
Pages
545-557
ISSN
0966-842X (ISSN-L)
DOI
10.1016/j.tim.2015.05.005
OpenAlex
W1816481481
Cited by
573
References
82
FWCI
1.24
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions. https://app.cochat.ai/papers/10.1016/j.tim.2015.05.005
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Römling, U., & Galperin, M. Y. (2015). Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions. Trends in Microbiology. https://doi.org/10.1016/j.tim.2015.05.005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.