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Cited by 287

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

The Burmese python genome reveals the molecular basis for extreme adaptation in snakes

Open access
Castoe, Todd A., de Koning, A. P. Jason, Hall, Kathryn T., Card, Daren C., Schield, Drew R., Fujita, Matthew K., Ruggiero, Robert P., Degner, Jack F., Daza, Juan M., Gu, Wanjun, Reyes-Velasco, Jacobo, Shaney, Kyle J., Castoe, Jill M., Fox, Samuel E., Poole, Alex W., Polanco, Daniel, Dobry, Jason, Vandewege, Michael W., Li, Qing, Schott, Ryan K., Kapusta, Aurélie, Minx, Patrick, Feschotte, Cédric, Uetz, Peter, Ray, David A., Hoffmann, Federico G., Bogden, Robert, Smith, Eric N., Chang, Belinda S. W., Vonk, Freek J., Casewell, Nicholas R., Henkel, Christiaan V., Richardson, Michael K., Mackessy, Stephen P., Bronikowski, Anne M., Yandell, Mark, Warren, Wesley C., Secor, Stephen M., Pollock, David D.·2013·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1314475110
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Abstract

Significance: The molecular basis of morphological and physiological adaptations in snakes is largely unknown. Here, we study these phenotypes using the genome of the Burmese python ( Python molurus bivittatus ), a model for extreme phenotypic plasticity and metabolic adaptation. We discovered massive rapid changes in gene expression that coordinate major changes in organ size and function after feeding. Many significantly responsive genes are associated with metabolism, development, and mammalian diseases. A striking number of genes experienced positive selection in ancestral snakes. Such genes were related to metabolism, development, lungs, eyes, heart, kidney, and skeletal structure—all highly modified features in snakes. Snake phenotypic novelty seems to be driven by the system-wide coordination of protein adaptation, gene expression, and changes in genome structure.

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Metadata

Authors
Castoe, T. A., de Koning, A. P. J., Hall, K. T., Card, D. C., Schield, D. R., Fujita, M. K., Ruggiero, R. P., Degner, J. F., Daza, J. M., Gu, W., Reyes-Velasco, J., Shaney, K. J., Castoe, J. M., Fox, S. E., Poole, A. W., Polanco, D., Dobry, J., Vandewege, M. W., Li, Q., Schott, R. K., Kapusta, A., Minx, P., Feschotte, C., Uetz, P., Ray, D. A., Hoffmann, F. G., Bogden, R., Smith, E. N., Chang, B. S. W., Vonk, F. J., Casewell, N. R., Henkel, C. V., Richardson, M. K., Mackessy, S. P., Bronikowski, A. M., Yandell, M., Warren, W. C., Secor, S. M., & Pollock, D. D.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2013-12-02
Volume
110
Issue
51
Pages
20645-20650
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1314475110
OpenAlex
W2017454882
Cited by
287
References
3
FWCI
13.18
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. https://app.cochat.ai/papers/10.1073/pnas.1314475110
The paper
Castoe, T. A., de Koning, A. P. J., Hall, K. T., Card, D. C., Schield, D. R., Fujita, M. K., Ruggiero, R. P., Degner, J. F., Daza, J. M., Gu, W., Reyes-Velasco, J., Shaney, K. J., Castoe, J. M., Fox, S. E., Poole, A. W., Polanco, D., Dobry, J., Vandewege, M. W., Li, Q., . . . Pollock, D. D. (2013). The Burmese python genome reveals the molecular basis for extreme adaptation in snakes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1314475110

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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