Integrative Physiology of Fasting

Secor, Stephen M.

doi:10.1002/cphy.c150013

Cited by 183Dietary Effects on HealthPhysiological and biochemical adaptationsGenetics, Aging, and Longevity in Model Organisms

Integrative Physiology of Fasting

Secor, Stephen M.·2016·Comprehensive physiology

DOI 10.1002/cphy.c150013

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Abstract

Extended bouts of fasting are ingrained in the ecology of many organisms, characterizing aspects of reproduction, development, hibernation, estivation, migration, and infrequent feeding habits. The challenge of long fasting episodes is the need to maintain physiological homeostasis while relying solely on endogenous resources. To meet that challenge, animals utilize an integrated repertoire of behavioral, physiological, and biochemical responses that reduce metabolic rates, maintain tissue structure and function, and thus enhance survival. We have synthesized in this review the integrative physiological, morphological, and biochemical responses, and their stages, that characterize natural fasting bouts. Underlying the capacity to survive extended fasts are behaviors and mechanisms that reduce metabolic expenditure and shift the dependency to lipid utilization. Hormonal regulation and immune capacity are altered by fasting; hormones that trigger digestion, elevate metabolism, and support immune performance become depressed, whereas hormones that enhance the utilization of endogenous substrates are elevated. The negative energy budget that accompanies fasting leads to the loss of body mass as fat stores are depleted and tissues undergo atrophy (i.e., loss of mass). Absolute rates of body mass loss scale allometrically among vertebrates. Tissues and organs vary in the degree of atrophy and downregulation of function, depending on the degree to which they are used during the fast. Fasting affects the population dynamics and activities of the gut microbiota, an interplay that impacts the host's fasting biology. Fasting-induced gene expression programs underlie the broad spectrum of integrated physiological mechanisms responsible for an animal's ability to survive long episodes of natural fasting.

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During prolonged fasting, comparable to the case of anorexia nervosa, microbes that utilize host intestinal mucins are able to flourish in the absence or shortage of dietary nutrients.
“Data from various classes of vertebrate hosts revealed that during prolonged fasting, comparable to the case of AN, microbes that utilize host intestinal mucins are able to flourish in the absence/shortage of dietary nutrients [74,75].”
From Are the gut bacteria telling us to eat or not to eat? reviewing the role of gut microbiota in the etiology, disease progression and treatment of eating disorders (2017) · cites this paper as [74]

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Intermittent Fasting Promotes White Adipose Browning and Decreases Obesity by Shaping the Gut Microbiota
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Decreased mitochondrial metabolic requirements in fasting animals carry an oxidative cost
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Coping with the cold: energy storage strategies for surviving winter in freshwater fish
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Environmental and host factors shaping the gut microbiota diversity of brown frog Rana dybowskii
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Thyroid Hormone Regulation and Insulin Resistance: Insights From Animals Naturally Adapted to Fasting
Martinez, B., & Ortiz, R. M. (2017) · Physiology · doi:10.1152/physiol.00018.2016 · Cited by 71 · see citing works
Feeding Rapidly Alters Microbiome Composition and Gene Transcription in the Clownfish Gut
Parris, D. J., Morgan, M. M., & Stewart, F. J. (2018) · Applied and Environmental Microbiology · doi:10.1128/aem.02479-18 · Cited by 68 · see citing works
On the Molecular Evolution of Leptin, Leptin Receptor, and Endospanin
Londraville, R. L., Prokop, J. W., Duff, R. J., Liu, Q., & Tuttle, M. A. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00058 · Cited by 70 · see citing works
More than just sugar: allocation of nectar amino acids and fatty acids in a Lepidopteran
Levin, E., McCue, M. D., & Davidowitz, G. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2016.2126 · Cited by 69 · see citing works
Learning to starve: impacts of food limitation beyond the stress period
McCue, M. D., Terblanche, J. S., & Benoit, J. B. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.157867 · Cited by 60 · see citing works
Traditional and Medical Applications of Fasting
Visioli, F., Mucignat‐Caretta, C., Anile, F., & Panaite, S.-A. (2022) · Nutrients · doi:10.3390/nu14030433 · Cited by 59 · see citing works
Fasting affects amino acid nitrogen isotope values: a new tool for identifying nitrogen balance of free-ranging mammals
Lübcker, N., Whiteman, J. P., Millar, R. P., de Bruyn, P. J. N., & Newsome, S. D. (2020) · Oecologia · doi:10.1007/s00442-020-04645-5 · Cited by 58 · see citing works
Intermittent Fasting: Potential Bridge of Obesity and Diabetes to Health?
Zang, B.-Y., He, L., & Xue, L. (2022) · Nutrients · doi:10.3390/nu14050981 · Cited by 56 · see citing works
Common and divergent molecular mechanisms of fasting and ketogenic diets
Paoli, A., Tinsley, G. M., Mattson, M. P., Vivo, I. D., Dhawan, R., & Moro, T. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.001 · Cited by 60 · see citing works
Blubber transcriptome response to acute stress axis activation involves transient changes in adipogenesis and lipolysis in a fasting-adapted marine mammal
Khudyakov, J. I., Champagne, C. D., Meneghetti, L. M., & Crocker, D. E. (2017) · Scientific Reports · doi:10.1038/srep42110 · Cited by 55 · see citing works
Starvation stress affects the maternal development and larval fitness in zebrafish (Danio rerio)
Fan, X., Hou, T., Sun, T., Zhu, L., Zhang, S., Tang, K., & Wang, Z. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.133897 · Cited by 54 · see citing works
Effect of increased rearing temperature on digestive function in cobia early juvenile
Yúfera, M., Nguyen, M. V., Navarro-Guillén, C., Moyano, F. J., Jordal, A. O., Espe, M., Conceição, L. E. C., Engrola, S. A. D., Le, M. H., & Rønnestad, I. (2019) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2019.01.007 · Cited by 49 · see citing works
Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice
Kim, Y. H., Lee, J. H., Yeung, J. L.-H., Das, E., Kim, R. Y., Jiang, Y., Moon, J. H., Jeong, H., Thakkar, N., Son, J. E., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-39380-2 · Cited by 46 · see citing works
Cachexia Anorexia Syndrome and Associated Metabolic Dysfunction in Peritoneal Metastasis
Archid, R., Solaß, W., Tempfer, C. M., Königsrainer, A., Adolph, M., Reymond, M. A., & Wilson, R. B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20215444 · Cited by 46 · see citing works
Food insecurity increases energetic efficiency, not food consumption: an exploratory study in European starlings
Melissa Bateson, B., Andrews, C. P., Dunn, J. C., Egger, C., Gray, F. E., Mchugh, M., & Nettle, D. (2021) · PeerJ · doi:10.7717/peerj.11541 · Cited by 44 · see citing works
Fasting ameliorates oxidative stress: A review of physiological strategies across life history events in wild vertebrates
Ensminger, D. C., Salvador‐Pascual, A., Arango, B. G., Allen, K. N., & Vázquez‐Medina, J. P. (2021) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2021.110929 · Cited by 42 · see citing works
A fasting period during grow-out make juvenile pacu (Piaractus mesopotamicus) leaner but does not impair growth
Fávero, G. C., Gimbo, R. Y., Franco‐Montoya, L. N., Carneiro, D. J., & Urbinati, E. C. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735242 · Cited by 41 · see citing works
Fasting induces hepatic lipid accumulation by stimulating peroxisomal dicarboxylic acid oxidation
Zhang, X., Gao, T., Deng, S., Shang, L., Chen, X., Chen, K., Li, P., Cui, X., & Zeng, J. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100622 · Cited by 42 · see citing works
Aestivation in Nature: Physiological Strategies and Evolutionary Adaptations in Hypometabolic States
Jiang, C., Storey, K. B., Yang, H., & Sun, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814093 · Cited by 40 · see citing works
The RCR and ATP/O Indices Can Give Contradictory Messages about Mitochondrial Efficiency
Salin, K., Villasevil, E. M., Anderson, G. J., Selman, C., Chinopoulos, C., & Metcalfe, N. B. (2018) · Integrative and Comparative Biology · doi:10.1093/icb/icy085 · Cited by 40 · see citing works
Enzymatic capacities of metabolic fuel use in cuttlefish (Sepia officinalis) and responses to food deprivation: insight into the metabolic organization and starvation survival strategy of cephalopods
Speers‐Roesch, B., Callaghan, N. I., MacCormack, T. J., Lamarre, S. G., Sykes, A. V., & Driedzic, W. R. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-0991-3 · Cited by 39 · see citing works
Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains
Jebb, D., & Hiller, M. (2018) · eLife · doi:10.7554/elife.38906 · Cited by 37 · see citing works
Structure and Function of Bone Marrow Adipocytes
de Paula, F. J. A., & Rosen, C. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c170010 · Cited by 38 · see citing works
Income and capital breeding in males: energetic and physiological limitations on male mating strategies
Soulsbury, C. D. (2019) · Journal of Experimental Biology · doi:10.1242/jeb.184895 · Cited by 34 · see citing works
Regulation of thermogenic adipocytes during fasting and cold
Reinisch, I., Schreiber, R., & Prokesch, A. (2020) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2020.110869 · Cited by 34 · see citing works
Glucose and lipid metabolic adaptations during postprandial starvation of Japanese flounder Paralichthys olivaceus previously fed different levels of dietary carbohydrates
Yang, M., Deng, K., Pan, M., Gu, Z., Liu, D., Zhang, Y., Zhang, W., & Mai, K. (2018) · Aquaculture · doi:10.1016/j.aquaculture.2018.12.003 · Cited by 33 · see citing works
Investigating Physical and Nutritional Changes During Prolonged Intermittent Fasting in Hemodialysis Patients: A Prospective Cohort Study
Adanan, N. I. H., Ali, M. S. M., Lim, J.-H., Zakaria, N. F., Lim, C. T. S., Yahya, R., Gafor, A. H. A., Karupaiah, T., & Daud, Z. A. M. (2019) · Journal of Renal Nutrition · doi:10.1053/j.jrn.2019.06.003 · Cited by 32 · see citing works
Human torpor: translating insights from nature into manned deep space expedition
Shi, Z., Qin, M., Huang, L., Xu, T., Chen, Y., Hu, Q., Peng, S., Peng, Z., Qu, L., Chen, S., et al. (2020) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12671 · Cited by 32 · see citing works
Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha
Li, G., Brocker, C. N., Yan, T., Xie, C., Krausz, K. W., Xiang, R., & Gonzalez, F. J. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.10.011 · Cited by 32 · see citing works
Gnrh2 maintains reproduction in fasting zebrafish through dynamic neuronal projection changes and regulation of gonadotropin synthesis, oogenesis, and reproductive behaviors
Marvel, M., Levavi‐Sivan, B., Wong, T., Zmora, N., & Zohar, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-86018-3 · Cited by 31 · see citing works
Health Benefits of Intermittent Fasting
Reddy, B. L., Reddy, V. S., & Saier, M. H. (2024) · Microbial Physiology · doi:10.1159/000540068 · Cited by 32 · see citing works
The oxidative debt of fasting: evidence for short to medium-term costs of advanced fasting in adult king penguins
Schull, Q., Viblanc, V. A., Stier, A., Saadaoui, H., Lefol, E., Criscuolo, F., Bize, P., & Robin, J. (2016) · Journal of Experimental Biology · doi:10.1242/jeb.145250 · Cited by 28 · see citing works
Feeding in Cartilaginous Fishes: An Interdisciplinary Synthesis
Huber, D., Wilga, C. D., Dean, M. N., Ferry, L. A., Gardiner, J. M., Habegger, M. L., Papastamatiou, Y. P., Ramsay, J. B., & Whitenack, L. B. (2019) · Fascinating life sciences · doi:10.1007/978-3-030-13739-7_8 · Cited by 27 · see citing works
Exposure of the Host-Associated Microbiome to Nutrient-Rich Conditions May Lead to Dysbiosis and Disease Development—an Evolutionary Perspective
Lachnit, T., Bosch, T. C. G., & Deines, P. (2019) · mBio · doi:10.1128/mbio.00355-19 · Cited by 27 · see citing works
Time‐limited diets and the gut microbiota in cardiometabolic disease
Ratiner, K., Shapiro, H., Goldenberg, K., & Elinav, E. (2022) · Journal of Diabetes · doi:10.1111/1753-0407.13288 · Cited by 26 · see citing works
Effects of Starvation and Refeeding on Growth, Digestion, Nonspecific Immunity and Lipid-Metabolism-Related Genes in Onychostoma macrolepis
Gou, N., Wang, K., Jin, T., & Yang, B. (2023) · Animals · doi:10.3390/ani13071168 · Cited by 25 · see citing works
Stress responses of testicular development, inflammatory and apoptotic activities in male zebrafish (Danio rerio) under starvation
Fan, X., Cui, L., Hou, T., Xue, X., Zhang, S., & Wang, Z. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103833 · Cited by 25 · see citing works
Probing metabolic memory in the hepatic response to fasting
Defour, M., Hooiveld, G. J. E. J., van Weeghel, M., & Kersten, S. (2020) · Physiological Genomics · doi:10.1152/physiolgenomics.00117.2020 · Cited by 25 · see citing works
Characteristics and a comparison of the gut microbiota in two frog species at the beginning and end of hibernation
Tong, Q., Dong, W., Xu, M., Hu, Z., Guo, P., Han, X.-Y., & Cui, L. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1057398 · Cited by 24 · see citing works
Gut microbiota—a positive contributor in the process of intermittent fasting-mediated obesity control
Rong, B., Wu, Q., Saeed, M., & Sun, C. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.09.009 · Cited by 24 · see citing works
The metabolic depression and revival of purple urchins (Strongylocentrotus purpuratus) in response to macroalgal availability
Dolinar, D., & Edwards, M. (2021) · Journal of Experimental Marine Biology and Ecology · doi:10.1016/j.jembe.2021.151646 · Cited by 22 · see citing works
Sex differences in the utilization of essential and non-essential amino acids in a Lepidoptera
Levin, E., McCue, M. D., & Davidowitz, G. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.154757 · Cited by 22 · see citing works
Genomic responses of DNA methylation and transcript profiles in zebrafish cells upon nutrient deprivation stress
Fan, X., Hou, T., Guan, Y., Li, X., Zhang, S., & Wang, Z. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137980 · Cited by 22 · see citing works
Metabolic depression in sea urchin barrens associated with food deprivation
Spindel, N. B., Lee, L. C., & Okamoto, D. K. (2021) · Ecology · doi:10.1002/ecy.3463 · Cited by 21 · see citing works
Dietary therapy to halt the progression of diabetes to diabetic kidney disease
Hu, H., Ding, G., & Liang, W. (2025) · Food & Function · doi:10.1039/d4fo06011c · Cited by 17 · see citing works
Examination of the role of resveratrol in attenuating oxidative damage induced by starvation stress in the marine mussel, Mytilus coruscus, through regulation of the sirt1-mediated signaling pathway
Chen, C., Xie, B., Sun, W., Gu, Z., Huang, J., Qi, P., Liao, Z., Zhang, X., & Yan, X. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.739047 · Cited by 17 · see citing works
Impact of intermittent fasting on human health: an extended review of metabolic cascades
Ahmed, A., Saeed, F., Arshad, M. U., Afzaal, M., Imran, A., Ali, S. W., Niaz, B., Ahmad, A., & Imran, M. (2018) · International Journal of Food Properties · doi:10.1080/10942912.2018.1560312 · Cited by 16 · see citing works
Key Performance Indicators of Common Carp (Cyprinus carpio L.) Wintering in a Pond and RAS under Different Feeding Schemes
Eljasik, P., Panicz, R., Sobczak, M., & Sadowski, J. (2022) · Sustainability · doi:10.3390/su14073724 · Cited by 16 · see citing works
Effects of Long-Term Fasting on Gut Microbiota, Serum Metabolome, and Their Association in Male Adults
Wu, F., Guo, Y., Wang, Y., Sui, X., Wang, H., Zhang, H., Xin, B., Yang, C., Zhang, C., Jiang, S., et al. (2024) · Nutrients · doi:10.3390/nu17010035 · Cited by 19 · see citing works
Maintenance of Distal Intestinal Structure in the Face of Prolonged Fasting: A Comparative Examination of Species From Five Vertebrate Classes
McCue, M. D., Passement, C. A., & Meyerholz, D. K. (2017) · The Anatomical Record · doi:10.1002/ar.23691 · Cited by 16 · see citing works
Alternate-day feeding leads to improved glucose regulation on fasting days without significant weight loss in genetically obese mice
Swoap, S. J., Bingaman, M. J., Hult, E. M., & Sandstrom, N. J. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00140.2019 · Cited by 16 · see citing works
Adiposity and fat metabolism during combined fasting and lactation in elephant seals
Fowler, M. A., Champagne, C. D., & Crocker, D. E. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.161554 · Cited by 15 · see citing works
Effect of jain fasting on anthropometric, clinical and biochemical parameters
Sanchetee, P., Sanchetee, P., & Garg, M. (2020) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_601_19 · Cited by 15 · see citing works
The effect of short-term fasting on the oxidative status of larvae of crested newt species and their hybrids
Prokić, M. D., Petrović, T. G., Despotović, S. G., Vučić, T. Z., Gavrić, J. P., Radovanović, T. B., & Gavrilović, B. R. (2020) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2020.110819 · Cited by 15 · see citing works
The fire of evolution: energy expenditure and ecology in primates and other endotherms
McGrosky, A., & Pontzer, H. (2023) · Journal of Experimental Biology · doi:10.1242/jeb.245272 · Cited by 15 · see citing works
Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application
Tarahovsky, Y. S., Fadeeva, I. S., Komelina, N. P., Khrenov, M. O., & Zakharova, N. M. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4496-2 · Cited by 15 · see citing works
Metabolic responses to starvation and feeding contribute to the invasiveness of an emerging pest insect
Smit, C., Javal, M., Lehmann, P., & Terblanche, J. S. (2020) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2020.104162 · Cited by 15 · see citing works
Inter‐individual variation in mitochondrial phosphorylation efficiency predicts growth rates in ectotherms at high temperatures
Dawson, N. J., Millet, C., Selman, C., & Metcalfe, N. B. (2022) · The FASEB Journal · doi:10.1096/fj.202101806rr · Cited by 14 · see citing works
Rapid stimulation of protein synthesis in digesting snakes: Unveiling a novel gut‐pancreas‐muscle axis
Rindom, E., Last, K. B., Svane, A., Fammé, A., Henriksen, P., Farup, J., Jessen, N., de Paoli, F. V., & Wang, T. (2025) · Acta Physiologica · doi:10.1111/apha.70006 · Cited by 13 · see citing works
Is starvation a cause of overmortality of the Mediterranean sardine?
Queiros, Q., Saraux, C., Dutto, G., Gasset, É., Marguerite, A., Brosset, P., Fromentin, J., & McKenzie, D. J. (2021) · Marine Environmental Research · doi:10.1016/j.marenvres.2021.105441 · Cited by 13 · see citing works
The intestinal environment as an evolutionary adaptation to mouthbrooding in the Astatotilapia burtoni cichlid
Faber-Hammond, J. J., Coyle, K. P., Bacheller, S. K., Roberts, C. G., Mellies, J. L., Roberts, R. B., & Renn, S. C. P. (2019) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiz016 · Cited by 13 · see citing works
Environmental variation associated with overwintering elicits marked metabolic plasticity in a temperate salmonid, Salvelinus fontinalis
Middleton, E. K., Gilbert, M. J. H., Landry, T., Lamarre, S. G., & Speers‐Roesch, B. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.246743 · Cited by 12 · see citing works
Fasting, a Potential Intervention in Alzheimer's Disease
Zeng, Z., Zhang, H., Wang, X., Shen, J., & Chen, D. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2303050 · Cited by 12 · see citing works
Partial immune responses in Sichuan bream (Sinibrama taeniatus) after starvation
Shi, J., Zhuo, D., Lu, M., Wang, H., Gu, H., Liu, X., & Wang, Z. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1098741 · Cited by 12 · see citing works
Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia
Sisa, C., Turroni, S., Amici, R., Brigidi, P., Candela, M., & Cerri, M. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i3.406 · Cited by 12 · see citing works
The consequences of seasonal fasting during the dormancy of tegu lizards ( Salvator merianae ) on their postprandial metabolic response
Gavira, R. S. B., Sartori, M. R., Gontero-Fourcade, M. N., Gomes, B. F., Abe, A. S., & Andrade, D. V. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.176156 · Cited by 11 · see citing works
Circadian rhythms in metabolic organs and the microbiota during acute fasting in mice
Pickel, L., Lee, J. H., Maughan, H., Shi, I. Q., Verma, N., Yeung, C., Guttman, D. S., & Sung, H. (2022) · Physiological Reports · doi:10.14814/phy2.15393 · Cited by 10 · see citing works
Expression of obesity-related adipokine genes during fasting in a naturally obese marine mammal
Khudyakov, J. I., Abdollahi, E., Ngo, A., Sandhu, G., Stephan, A. P., da Costa, D. P., & Crocker, D. E. (2019) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00182.2019 · Cited by 11 · see citing works
Energy expenditure and body composition in a hibernator, the alpine marmot
Ruf, T., Michel, M., Frey‐Roos, A., Flatz, S., & Tataruch, F. (2022) · Journal of Comparative Physiology B · doi:10.1007/s00360-022-01466-1 · Cited by 10 · see citing works
Three steps down: Metabolic depression in winter-acclimatized crucian carp (Carassius carassius L.)
Haverinen, J., Badr, A., Eskelinen, M., & Vornanen, M. (2023) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2023.111537 · Cited by 10 · see citing works
Physiological and behavioral responses to social isolation and starvation in a social fish
Xu, D., Wang, C., Bi, J.-Q., Luo, H., Fu, S., Li, B., & Zeng, L.-Q. (2024) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2024.106384 · Cited by 10 · see citing works
Advance social information allows red crossbills ( Loxia curvirostra ) to better conserve body mass and intestinal mass during food stress
Cornelius, J. M. (2022) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2022.0516 · Cited by 10 · see citing works
Previous Repeated Exposure to Food Limitation Enables Rats to Spare Lipid Stores during Prolonged Starvation
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Authors: Secor, S. M.
Affiliations: University of Alabama (US)
Corresponding author: Secor, Stephen M.
ORCID: Secor, Stephen M.
Venue: Comprehensive physiology
Publisher: Wiley
Published: 2016-03-15
Volume: 6
Issue: 2
Pages: 773-825
ISSN: 2040-4603 (ISSN-L)
DOI: 10.1002/cphy.c150013
OpenAlex: W2441362792
Cited by: 183
References: 586
Citations by year: 2026: 7 · 2025: 18 · 2024: 30 · 2023: 16 · 2022: 19 · 2021: 27 · 2020: 20 · 2019: 16 · 2018: 12 · 2017: 13 · 2016: 5
Type: other
Language: en
Open access: closed
Licence: doi.wiley.com/10.1002/tdm_license_1.1 (tdm)
Locations: Comprehensive physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Dietary Effects on Health
Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Keywords: fasting, energy homeostasis, metabolic rate reduction, lipid utilization, hormonal regulation, immune function, tissue atrophy, weight loss, fat stores, gut microbiota, allometric scaling, survival strategies, hibernation, aestivation, migration
MeSH terms: Animals, Energy Metabolism, Fasting, Animal Migration, Torpor

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