The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees
Open accessAbstract
Significance: Honey bees are exposed to a wealth of synergistically interacting stress factors, which may induce colony losses often associated with high infection levels of pathogens. Neonicotinoid insecticides have been reported to enhance the impact of pathogens, but the underlying immune alteration is still obscure. In this study we describe the molecular mechanism through which clothianidin adversely affects the insect immune response and promotes replication of a viral pathogen in honey bees bearing covert infections. Our results shed light on a further level of regulation of the immune response in insects and have implications for bee conservation.
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Citations
Cites
Jones, J. D. G., & Dangl, J. L. (2006) · Nature · doi:10.1038/nature05286 · Cited by 13,177
Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154 · cited 2×
“The inflammatory reflex circuit described in mammals is essential to ensure a neural coordination of the defense response to have a sufficient protection while preventing damages deriving from an overzealous reaction (44, 45).”
BackgroundRethinking inflammation: neural circuits in the regulation of immunity
Olofsson, P. S., Rosas‐Ballina, M., Levine, Y. A., & Tracey, K. J. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01138.x · Cited by 393 · cited 2×
“The most reasonable explanation accounting for such an effect is the possible occurrence in insects of neural circuits controlling immunity, as reported in mammals (43).”
Background
Cited by
Worldwide decline of the entomofauna: A review of its drivers
Sánchez-Bayo, F., & Wyckhuys, K. A. G. (2019) · Biological Conservation · doi:10.1016/j.biocon.2019.01.020 · Cited by 3,462
The environmental risks of neonicotinoid pesticides: a review of the evidence post 2013
Wood, T. J., & Goulson, D. (2017) · Environmental Science and Pollution Research · doi:10.1007/s11356-017-9240-x · Cited by 623
Chronic exposure to neonicotinoids reduces honey bee health near corn crops
Tsvetkov, N., Samson-Robert, O., Sood, K., Patel, H. S., Malena, D. A., Gajiwala, P. H., Maciukiewicz, P., Fournier, V., & Zayed, A. (2017) · Science · doi:10.1126/science.aam7470 · Cited by 555
Hladik, M. L., Kolpin, D. W., & Kuivila, K. M. (2014) · Environmental Pollution · doi:10.1016/j.envpol.2014.06.033 · Cited by 407
Doublet, V., Labarussias, M., de Miranda, J. R., Moritz, R. F. A., & Paxton, R. J. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12426 · Cited by 406
Metadata
- Authors
- Di Prisco, G., Cavaliere, V., Annoscia, D., Varricchio, P., Caprio, E., Nazzi, F., Gargiulo, G., & Pennacchio, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-10-21
- Volume
- 110
- Issue
- 46
- Pages
- 18466-18471
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097288065
- Cited by
- 671
- References
- 3
- FWCI
- 50.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Di Prisco, G., Cavaliere, V., Annoscia, D., Varricchio, P., Caprio, E., Nazzi, F., Gargiulo, G., & Pennacchio, F. (2013). Neonicotinoid clothianidin adversely affects insect immunity and promotes replication of a viral pathogen in honey bees. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1314923110
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