The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy
Open accessAbstract
Significance: Cardiac failure is a leading cause of mortality worldwide and a major financial burden for healthcare systems. New tools for understanding cardiovascular disease and developing better therapeutic approaches are therefore needed. To this end, transcriptional regulation has been extensively studied in cardiac hypertrophy and failure, but there is still a lack of understanding of the epigenetic framework in which transcription factors act. Our report adds significant knowledge to the field because we demonstrate, in vivo, that a complex and specific epigenetic signature regulates gene expression by modulating promoters and enhancers, a large number of which have been described here. These findings advance our understanding of the mechanisms underlying this pathology.
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Trapnell, C., Williams, B. A., Pertea, G., Mortazavi, A., Kwan, G., van Baren, M. J., Salzberg, S. L., Wold, B. J., & Pachter, L. (2010) · Nature Biotechnology · doi:10.1038/nbt.1621 · Cited by 15,556
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
GREAT improves functional interpretation of cis-regulatory regions
McLean, C. Y., Bristor, D., Hiller, M., Clarke, S. L., Schaar, B. T., Lowe, C. B., Wenger, A. M., & Bejerano, G. (2010) · Nature Biotechnology · doi:10.1038/nbt.1630 · Cited by 4,502
Mapping and analysis of chromatin state dynamics in nine human cell types
Ernst, J., Kheradpour, P., Mikkelsen, T. S., Shoresh, N., Ward, L. D., Epstein, C. B., Zhang, X., Wang, L., Issner, R., Coyne, M., et al. (2011) · Nature · doi:10.1038/nature09906 · Cited by 2,898
A unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233
Cited by
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy
Wang, Z., Zhang, X.-J., Ji, Y.-X., Zhang, P., Deng, K.-Q., Gong, J., Ren, S., Wang, X., Chen, I., Wang, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4179 · Cited by 386
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Cui, M., Wang, Z., Bassel-Duby, R., & Olson, E. N. (2018) · Development · doi:10.1242/dev.171983 · Cited by 92
BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy
Antolic, A., Wakimoto, H., Jiao, Z., Gorham, J. M., DePalma, S. R., Lemieux, M. E., Conner, D. A., Lee, D. Y., Qi, J., Seidman, J. G., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.138687 · Cited by 41
Metadata
- Authors
- Papait, R., Cattaneo, P., Kunderfranco, P., Greco, C., Carullo, P., Guffanti, A., Viganò, V., Stirparo, G. G., Latronico, M. V. G., Hasenfuss, G., Chen, J., & Condorelli, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2013-11-27
- Volume
- 110
- Issue
- 50
- Pages
- 20164-20169
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2113564565
- Cited by
- 231
- References
- 5
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. https://app.cochat.ai/papers/10.1073/pnas.1315155110
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- Papait, R., Cattaneo, P., Kunderfranco, P., Greco, C., Carullo, P., Guffanti, A., Viganò, V., Stirparo, G. G., Latronico, M. V. G., Hasenfuss, G., Chen, J., & Condorelli, G. (2013). Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315155110
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
