Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease

Role of YAP/TAZ in mechanotransduction

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Evidence for Cardiomyocyte Renewal in Humans

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A Calcineurin-Dependent Transcriptional Pathway for Cardiac Hypertrophy

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Transient Regenerative Potential of the Neonatal Mouse Heart

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Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors

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In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes

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Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

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GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

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The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

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Building the mammalian heart from two sources of myocardial cells

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Heart repair by reprogramming non-myocytes with cardiac transcription factors

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Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5.Preprint

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Control of Mouse Cardiac Morphogenesis and Myogenesis by Transcription Factor MEF2C

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A Murine Model of Holt-Oram Syndrome Defines Roles of the T-Box Transcription Factor Tbx5 in Cardiogenesis and Disease

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Neuregulin1/ErbB4 Signaling Induces Cardiomyocyte Proliferation and Repair of Heart Injury

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Gene Regulatory Networks in the Evolution and Development of the Heart

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Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

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De novo mutations in histone-modifying genes in congenital heart disease

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The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

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Hippo pathway effector Yap promotes cardiac regeneration

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MyoD1: A Nuclear Phosphoprotein Requiring a Myc Homology Region to Convert Fibroblasts to Myoblasts

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De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies

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Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

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Cardiomyocyte proliferation contributes to heart growth in young humans

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Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND

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ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

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The extracellular matrix protein agrin promotes heart regeneration in mice

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Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage

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Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation

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Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration

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The cardiac homeobox gene Csx/Nkx2 . 5 lies genetically upstream of multiple genes essential for heart development

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Meis1 regulates postnatal cardiomyocyte cell cycle arrest

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The Hand1 bHLH transcription factor is essential for placentation and cardiac morphogenesis

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Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

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Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair

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Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

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Chromatin regulation by Brg1 underlies heart muscle development and disease

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Heart development: molecular insights into cardiac specification and early morphogenesis

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Hippo pathway deficiency reverses systolic heart failure after infarction

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Return to the fetal gene program

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Therapeutic approaches for cardiac regeneration and repair

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Myosin heavy chain gene expression in human heart failure.

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Response of the adult newt ventricle to injury

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Cardiomyocyte Regeneration: A Consensus Statement.

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Mesp1 Acts as a Master Regulator of Multipotent Cardiovascular Progenitor Specification

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The Hippo pathway in the heart: pivotal roles in development, disease, and regeneration

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Mef2cis a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development

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The Transcription Factors GATA4 and GATA6 Regulate Cardiomyocyte Hypertrophy in Vitro and in Vivo

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GATA4 is essential for formation of the proepicardium and regulates cardiogenesis

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Cardiac regeneration strategies: Staying young at heart

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Targeted Expression of Cyclin D2 Results in Cardiomyocyte DNA Synthesis and Infarct Regression in Transgenic Mice

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Bop encodes a muscle-restricted protein containing MYND and SET domains and is essential for cardiac differentiation and morphogenesis

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Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart

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Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

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Transcription Factor Pathways and Congenital Heart Disease

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Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics

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Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish

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MiR‐133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

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A Proliferative Burst during Preadolescence Establishes the Final Cardiomyocyte Number

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Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

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PRC2 directly methylates GATA4 and represses its transcriptional activityPreprint

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Calcineurin Signaling and Muscle Remodeling

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Functional Modulation of Cardiac Form through Regionally Confined Cell Shape Changes

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Signaling and Transcriptional Networks in Heart Development and RegenerationPreprint

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Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq

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Dystrophin–glycoprotein complex sequesters Yap to inhibit cardiomyocyte proliferation

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The Transcription Factor GATA4 Is Activated by Extracellular Signal-Regulated Kinase 1- and 2-Mediated Phosphorylation of Serine 105 in Cardiomyocytes

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Small changes in expression affect predisposition to tumorigenesis

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Control of early cardiac-specific transcription of Nkx2-5 by a GATA-dependent enhancer

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Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

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The deployment of cell lineages that form the mammalian heart

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Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

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Large-scale discovery of enhancers from human heart tissue

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Embryonic Heart Progenitors and Cardiogenesis

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Early patterning and specification of cardiac progenitors in gastrulating mesoderm

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Multicellular Transcriptional Analysis of Mammalian Heart Regeneration

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No Evidence for Cardiomyocyte Number Expansion in Preadolescent Mice

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Cardiac morphology and blood pressure in the adult zebrafish

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Glycogen Synthase Kinase 3β Regulates GATA4 in Cardiac Myocytes

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IGF signaling directs ventricular cardiomyocyte proliferation during embryonic heart development

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Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy

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Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming

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Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoAPreprint

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Cardiac Development and Factors Influencing the Development of Congenital Heart Defects (CHDs): Part I

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Recent Experimental Studies of Maternal Obesity, Diabetes during Pregnancy and the Developmental Origins of Cardiovascular Disease

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Transcription factor NFYa controls cardiomyocyte metabolism and proliferation during mouse fetal heart development

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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Heart regeneration: beyond new muscle and vessels

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Deficiency of NONO is associated with impaired cardiac function and fibrosis in mice

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Two decades of heart regeneration research: Cardiomyocyte proliferation and beyond

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Responsiveness to perturbations is a hallmark of transcription factors that maintain cell identity in vitro

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Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts

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Pathobiology of myocardial and cardiomyocyte injury in ischemic heart disease: Perspective from seventy years of cell injury research

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Emerging role of interleukin‐13 in cardiovascular diseases: A ray of hope

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Emerging Trends in Mesenchymal Stem Cells Applications for Cardiac Regenerative Therapy: Current Status and Advances

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In-Depth Genomic Analysis: The New Challenge in Congenital Heart Disease

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The opportunities and challenges of using Drosophila to model human cardiac diseases

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Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging

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A surgical mouse model of neonatal pressure overload by transverse aortic constriction

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DNA Tension Probes Show that Cardiomyocyte Maturation Is Sensitive to the Piconewton Traction Forces Transmitted by Integrins

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SEMA6D regulates perinatal cardiomyocyte proliferation and maturation in mice

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Cardiomyocyte Ploidy, Metabolic Reprogramming and Heart Repair

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Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks directing human cardiac development

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Advancing Cardiomyocyte Maturation: Current Strategies and Promising Conductive Polymer‐Based Approaches

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Targeting Epigenetic Regulation of Cardiomyocytes through Development for Therapeutic Cardiac Regeneration after Heart Failure

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Human Heart Morphogenesis: A New Vision Based on In Vivo Labeling and Cell Tracking

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Genetic lineage tracing identifies adaptive mechanisms of pancreatic islet β cells in various mouse models of diabetes with distinct age of initiation

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Cilia at the crossroad: convergence of regulatory mechanisms to govern cilia dynamics during cell signaling and the cell cycle

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Postnatal expression of cell cycle promoter Fam64a causes heart dysfunction by inhibiting cardiomyocyte differentiation through repression of Klf15

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Neutrophil and T Cell Functions in Patients with Congenital Heart Diseases: A Review

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Downregulated developmental processes in the postnatal right ventricle under the influence of a volume overload

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Leveraging chromatin state transitions for the identification of regulatory networks orchestrating heart regeneration

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Fibrinogen‐like protein 2 contributes to normal murine cardiomyocyte maturation and heart development

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The enigma of cancer polyploidy as deciphered by evolutionary cancer cell biology (ECCB)

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MiR-133b as a crucial regulator of TCS-induced cardiotoxicity via activating β-adrenergic receptor signaling pathway in zebrafish embryos

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Cardiomyocyte‐specific Srsf3 deletion reveals a mitochondrial regulatory role

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Loss of the ciliary protein Chibby1 in mice leads to exocrine pancreatic degeneration and pancreatitis

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Cardiomyocyte-derived circulating extracellular vesicles allow a non-invasive liquid biopsy of myocardium in health and diseasePreprint

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Myoglobin modulates the Hippo pathway to promote cardiomyocyte differentiation

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Cardiomyocyte proliferation and regeneration in congenital heart disease

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The characteristics of proliferative cardiomyocytes in mammals

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Ubiquitous MEIS transcription factors actuate lineage-specific transcription to establish cell fate

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Non-viral approaches for somatic cell reprogramming into cardiomyocytes

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The role of mechanosignaling in the control of myocardial mass

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Cardiac competence of the paraxial head mesoderm fades concomitant with a shift towards the head skeletal muscle programme

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Mitogen-activated protein kinase signalling in rat hearts during postnatal development: MAPKs, MAP3Ks, MAP4Ks and DUSPs

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Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal

Li­, ­., Lee, J., Miwa, K., Kuramoto, Y., Masuyama, K., Yasutake, H., Tomoyama, S., Nakanishi, H., & Sakata, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.591754 · Cited by 4 · see citing works

The evolutionary ancient MEIS transcription factors actuate lineage-specific transcription to establish cardiac fatePreprint

Darieva, Z. A., Zarrineh, P., Phillips, N., Mallen, J., Garcia-Mora, A., Donaldson, I. J., Bridoux, L., Douglas, M., Henriques, S. F. D., Schulte, D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.18.604075 · Cited by 4 · see citing works

Fluorescent PSC-Derived Cardiomyocyte Reporter Lines: Generation Approaches and Their Applications in Cardiovascular Medicine

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Predictive Role of Cluster Bean (Cyamopsis tetragonoloba) Derived miRNAs in Human and Cattle Health

Sahu, S., Rao, A. R., Sahu, T. K., Pandey, J., Varshney, S., Kumar, A., & Gaikwad, K. (2024) · Genes · doi:10.3390/genes15040448 · Cited by 3 · see citing works

Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial functionPreprint

Xu, W., Billon, C., Li, H., Hayes, M. E., Yu, K., Losby, M., Hampton, C. S., Adeyemi, C. M., Graves, A., Nasiotis, E. T., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.02.14.480431 · Cited by 3 · see citing works

The Role of Epigenetics in Cardiovascular Disease: Providing Insights into Disease Mechanisms and Evaluating Therapeutic Potential for Future Treatment Strategies

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A three-dimensional spatial transcriptome atlas reconstructs early organogenesis in primate Carnegie stages 9 and 10 embryos

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Gene editing and therapy in acquired and inherited cardiovascular disorders

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HDAC7 promotes cardiomyocyte proliferation by suppressing myocyte enhancer factor 2

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Comparative genomics analyses reveal sequence determinants underlying interspecies variations in injury-responsive enhancers

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The cardiac phospho-proteome during pressure overload in mice

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Myosin inhibition enhances cardiomyocyte cell cycle activity through SIRT1-NFAT-mediated H3K9me3 modification

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Proregenerative MicroRNAs to Repair the Damaged Heart

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Drosophila Models Reveal NAT Complex Roles in Heart Development and Enable Functional Validation of Congenital Heart Disease Variants

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Essential role of NONO-HOXA1-Wnt axis in cardiomyocyte differentiation

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Stem Cell Applications in Cardiac Tissue Regeneration

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Substance P/neurokinin1 receptor is associated with the expression of cardiac stem/pluripotency-associated genes in diabetic right and left atriaPreprint

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Transient induction of cell cycle promoter Fam64a improves cardiac function through regulating Klf15-dependent cardiomyocyte differentiation in micePreprint

Hashimoto, K., Kodama, A., Ohira, M., Kimoto, M., Nakagawa, R., Usui, Y., Ujihara, Y., Hanashima, A., & Mohri, S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.04.01.438048 · Cited by 1 · see citing works

Cardiomyocytes in the Mammalian Adult Heart

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Tissues & Organs | Biochemistry of Development: Striated Muscle

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Faculty Opinions recommendation of Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing.

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Stem Cell Applications in Cardiac Tissue Regeneration

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Myoglobin promotes cardiomyocyte differentiation through oxidatively modulating the Hippo Kinase PathwayPreprint

Rao, K., Rochon, E. R., Singh, A. B., Jagnnathan, R., Peng, Z., Moulik, M., Zhang, M., Corti, P., & Shiva, S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.31.506050

Insight into the regulatory mechanism of dynamic chromatin 3D interactions during cardiomyocyte differentiation in human

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Exploring the role non-coding RNAs during myocardial cell fate

Franco, D., Sánchez–Fernández, C., García‐Padilla, C., & Lozano-Velasco, E. (2024) · Biochemical Society Transactions · doi:10.1042/bst20231216

Balancing precision with plasticity: Redefining the roles of transcription factors in early cell fate specificationPreprint

Abbasi, S., Li, S., Charitos, G., Chrysostomou, E., Zhou, W., Apostolidis, P., Borad, P., He, P., & Koromila, T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.11.636561

Muscle and Nerve Development in Health and Disease

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Pre-differentiation of Mesenchymal Stem Cells with GATA-4 and MEF2C Enhances Cardiac Function Post-Myocardial Infarction in Rats

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The Phoenix Heart—PICSO and the Rebirth of Embryonic Life in the Ischemic Myocardium

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The epidermal growth factor (EGF) receptor family network in cardiac hypertrophy and heart failurePreprint

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Resetting the epigenome for heart regeneration.

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Epigenetic Regulation of Mammalian Cardiomyocyte Development

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Mechanisms of Cardiomyocyte Proliferation and Differentiation in Development and Regeneration

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Epigenetic Control of Mammalian Cardiomyocyte Proliferation

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Targeting Epigenetic Regulation of Cardiomyocytes through Development for Therapeutic Cardiac Regeneration after Heart Failure

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