The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Ischemic neurons recruit natural killer cells that accelerate brain infarction
Open accessAbstract
Significance: Stroke is a devastating illness second only to cardiac ischemia as a cause of death worldwide. Long-time attempts to salvage dying neurons and preserve neurological functions via various neuroprotective agents have failed, owing at least in part to medical science’s limited knowledge of ischemia-induced elements that participate in irreversible neurovascular damage. The present study was performed to understand the role of natural killer (NK) cells, a key member of the innate immune system, in stroke. We discovered that NK cells infiltrated the brains of stroke patients and mice with induced stroke. Multiple pathways by which NK cells exacerbate brain infarction are discovered. This study revealed the role of NK cells in the pathogenesis of stroke.
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Cites
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Cited by
Inflammation and Stroke: An Overview
Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 958
Global brain inflammation in stroke
Shi, K., Tian, D.-C., Li, Z.-G., Ducruet, A. F., Lawton, M. T., & Shi, F.-D. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30078-x · Cited by 911
Self-citationImmune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
Pathogenic mechanisms following ischemic stroke
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Depletion of microglia exacerbates postischemic inflammation and brain injury
Jin, W.-N., Shi, S. X.-Y., Li, Z., Li, M., Wood, K., Gonzales, R. J., & Liu, Q. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17694185 · Cited by 351
“Quantitative analysis of immune cell subsets or cytokines was prepared from spleen or brain tissues and stained with fluorochrome-conjugated antibodies as described.(40,44,46) For in vitro experiments, 0.”
InfluentialSelf-citation
Metadata
- Authors
- Gan, Y., Liu, Q., Wu, W., Yin, J.-X., Bai, X.-F., Shen, R., Wang, Y., Chen, J., La Cava, A., Poursine-Laurent, J., Yokoyama, W., & Shi, F.-D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-02-03
- Volume
- 111
- Issue
- 7
- Pages
- 2704-2709
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1964730250
- Cited by
- 273
- References
- 34
- FWCI
- 8.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gan, Y., Liu, Q., Wu, W., Yin, J.-X., Bai, X.-F., Shen, R., Wang, Y., Chen, J., La Cava, A., Poursine-Laurent, J., Yokoyama, W., & Shi, F.-D. (2014). Ischemic neurons recruit natural killer cells that accelerate brain infarction. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1315943111
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