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Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota
Open accessAbstract
Significance: Metabolism of l -carnitine, a compound abundant in human diet, to trimethylamine by human microbiota has been shown to promote atherosclerosis and subsequent development of heart disease. However, the underpinning molecular and biochemical mechanisms remain unknown. In this study, we reveal that a previously unidentified Rieske-type protein is responsible for carnitine transformation to trimethylamine from human microbiota. Knowledge gained in our study provides the opportunity not only to explore Rieske protein inhibitors in preventing trimethylamine formation in animal studies and clinical trials, but also for its use as a functional genetic marker to better understand human microbiota and their dynamics in our health and disease in future epidemiological studies and dietary interventions.
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In the citing paper
“While mammals do not have the enzyme, gut microbes have TMA lyases, which can cleave the C-N bond of these nutrients, releasing the TMA moiety as a waste product.”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [77]
In the citing paper
“Thus far, 2 distinct microbial enzyme systems have been identified in vitro that can produce TMA from either choline or carnitine as substrate (75,77).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [77]
In the citing paper
“Similarly, a microbial oxygenase (CntA) complexes with the microbial reductase (CntB) to form an active complex that selectively uses carnitine as substrate and forms TMA (carnitine TMA lyase activity).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [77]
In the citing paper
“Characterization of recombinant isolated CntA/B showed they formed a 2-component Rieske-type oxygenase/reductase complex (77).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [77]
In the citing paper
“In other studies that used a similar bioinformatics approach with Acinetobacter baumannii as the model, an alternative microbial enzyme cluster (catalytic and regulatory protein CntA and CntB) specific for carnitine TMA lyase activity was also recently reported (77).”
From The contributory role of gut microbiota in cardiovascular disease (2014) · cites this paper as [77]
In the citing paper
“Carnitine oxidoreductase is the main enzyme responsible for the conversion of L-carnitine into TMA [20]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [20]
In the citing paper
“Two genes, CntA and CntB, encode a two-subunit oxidoreductase (A encodes the carnitine oxidase, and B encodes a reductase) for L-carnitine conversion to TMA (confirmed by a series of knockout and heterologous expression experiments) (137).”
From Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [137]
In the citing paper
“TMA is also produced by carnitine oxygenase, a Rieske-type protein, using carnitine found in red meat as a substrate (Zhu et al., 2014).”
From Gut reactions: Breaking down xenobiotic–microbiome interactions (2019) · cites this paper as Zhu et al., 2014
In the citing paper
“Two major TMA-synthesis pathways have been described with a specific glycyl radical enzyme, the choline TMA-lyase (CutC) and its activator CutD [6], that takes choline as a substrate and a two-component Rieske-type oxygenase/reductase (CntA/B) [7], which acts on carnitine and its derivative gamma-butyrobetaine, as the key enzymes.”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“In this study, we, hence, considered YeaW as belonging to the CntA cluster of enzymes as originally proposed by Zhu and colleagues [7].”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“All sequences (with one exception) display a conserved “bridging” glutamate instead of aspartate (E205D), which was previously suggested as a signature for that enzyme [7].”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“The established databases present a comprehensive update of previous cutC [9] and cntA [7] gene sequence collections adding a multitude of new gene sequences.”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“TMA formation via cntA represents a distinctive branch of TMA synthesis”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“Thus, specific conditions that select against the latter bacteria might be compensated by an increase of taxa encoding CntA [7]”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“ecophysiologic features of its key player, E. coli, are substantially different to those of the major cutC-exhibiting taxa”
From Uncovering the trimethylamine-producing bacteria of the human gut microbiota (2017) · cites this paper as [7]
In the citing paper
“Human and animal studies suggest that several families of bacteria are involved in TMA/TMAO production, namely, Deferribacteraceae, Anaeroplasmataceae, Prevotellaceae [3] and Enterobacteriaceae [18,19].”
From Trimethylamine N-oxide: the good, the bad and the unknown. (2016) · cites this paper as [19]
In the citing paper
“However, the patients did have decreased risk for rehospitalization.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [224]
In the citing paper
“the authors did not see long-term benefits in mortality224.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [224]
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Citations
Cites
The Pfam Protein Families Database
Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,075
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
Structure, function and diversity of the healthy human microbiome
The Human Microbiome Project Consortium (2012) · Nature · doi:10.1038/nature11234 · Cited by 11,726
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513
Self-citationGut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Cited by
Sorted by citations
The gut microbiome in atherosclerotic cardiovascular disease
Jie, Z., Xia, H., Zhong, S.-L., Feng, Q., Li, S., Liang, S., Zhong, H., Liu, Z., Gao, Y., Zhao, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00900-1 · Cited by 1,638
Wang, Z., Roberts, A. B., Buffa, J. A., Levison, B. S., Zhu, W., Org, E., Gu, X., Huang, Y., Zamanian-Daryoush, M., Culley, M. K., et al. (2015) · Cell · doi:10.1016/j.cell.2015.11.055 · Cited by 1,317
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789
Yang, W., & Cong, Y. (2021) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00661-4 · Cited by 715
The contributory role of gut microbiota in cardiovascular disease
Tang, W. H. W., & Hazen, S. L. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72331 · Cited by 641
Janeiro, M., Ramírez, M., Milagro, F., Martínez, J., & Solas, M. (2018) · Nutrients · doi:10.3390/nu10101398 · Cited by 631
“Carnitine oxidoreductase is the main enzyme responsible for the conversion of L-carnitine into TMA [20] (Figure 1).”
Backgroundγ-Butyrobetaine Is a Proatherogenic Intermediate in Gut Microbial Metabolism of L-Carnitine to TMAO
Koeth, R. A., Levison, B. S., Culley, M. K., Buffa, J. A., Wang, Z., Gregory, J. C., Org, E., Wu, Y., Li, L., Smith, J. D., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.10.006 · Cited by 546
Uncovering the trimethylamine-producing bacteria of the human gut microbiota
Rath, S., Heidrich, B., Pieper, D. H., & Vital, M. (2017) · Microbiome · doi:10.1186/s40168-017-0271-9 · Cited by 515
Trimethylamine N-oxide: the good, the bad and the unknown.
Velasquez, M., Ramezani, A., Manal, A., & Raj, D. (2016) · Toxins · doi:10.3390/toxins8110326 · Cited by 504
Zhang, L., & Davies, S. S. (2016) · Genome Medicine · doi:10.1186/s13073-016-0296-x · Cited by 521
Intestinal Microbiota in Cardiovascular Health and Disease
Tang, W. H. W., Bäckhed, F., Landmesser, U., & Hazen, S. L. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.03.024 · Cited by 524
Gut microbiota derived metabolites in cardiovascular health and disease
Wang, Z., & Zhao, Y. (2018) · Protein & Cell · doi:10.1007/s13238-018-0549-0 · Cited by 491
Trimethylamine N -Oxide, the Microbiome, and Heart and Kidney Disease
Zeisel, S. H., & Warrier, M. (2017) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064732 · Cited by 475
Trøseid, M., Ueland, T., Hov, J. R., Svardal, A., Gregersen, I., Dahl, C. P., Aakhus, S., Gude, E., Bjørndal, B., Halvorsen, B., et al. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12328 · Cited by 464
Microbial modulation of cardiovascular disease
Brown, J. M., & Hazen, S. L. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.149 · Cited by 440
The Gut Microbial Endocrine Organ: Bacterially Derived Signals Driving Cardiometabolic Diseases
Brown, J. M., & Hazen, S. L. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-060513-093205 · Cited by 438
The microbiome and gut homeostasis
Lee, J., Tsolis, R. M., & Bäumler, A. J. (2022) · Science · doi:10.1126/science.abp9960 · Cited by 452
Precision Nutrition and the Microbiome, Part I: Current State of the Science
Mills, S., Stanton, C., Lane, J. A., Smith, G., & Ross, R. P. (2019) · Nutrients · doi:10.3390/nu11040923 · Cited by 426
Trace Amines and Their Receptors
Gainetdinov, R. R., Hoener, M. C., & Berry, M. D. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015305 · Cited by 398
The dormant blood microbiome in chronic, inflammatory diseases
Potgieter, M., Bester, J., Kell, D. B., & Pretorius, E. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv013 · Cited by 384
Lim, Y. J., Sidor, N. A., Tonial, N. C., Che, A., & Urquhart, B. L. (2021) · Toxins · doi:10.3390/toxins13020142 · Cited by 400
Fennema, D., Phillips, I. R., & Shephard, E. A. (2016) · Drug Metabolism and Disposition · doi:10.1124/dmd.116.070615 · Cited by 355
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
Koeth, R. A., Lam-Galvez, B. R., Kirsop, J., Wang, Z., Levison, B. S., Gu, X., Copeland, M. F., Bartlett, D., Cody, D. B., Dai, H. J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94601 · Cited by 327
High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N -oxide
Yoo, W., Zieba, J. K., Foegeding, N. J., Torres, T. P., Shelton, C. D., Shealy, N. G., Byndloss, A. J., Cevallos, S. A., Gertz, E., Tiffany, C. R., et al. (2021) · Science · doi:10.1126/science.aba3683 · Cited by 332
Gut reactions: Breaking down xenobiotic–microbiome interactions
Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., & Hyland, N. P. (2019) · Pharmacological Reviews · doi:10.1124/pr.118.015768 · Cited by 319
TMAO: how gut microbiota contributes to heart failure
Zhang, Y., Wang, Y., Ke, B., & Du, J. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.007 · Cited by 311
Xu, K., Xia, G., Lu, J.-Q., Chen, M.-X., Zhen, X., Wang, S., You, C., Nie, J., Zhou, H., & Yin, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-01387-y · Cited by 268
Tang, W. H. W., Wang, Z., Li, X. S., Fan, Y., Li, D. S., Wu, Y., & Hazen, S. L. (2016) · Clinical Chemistry · doi:10.1373/clinchem.2016.263640 · Cited by 234
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
Canyelles, M., Borràs, C., Rotllán, N., Tondo, M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24031940 · Cited by 218
Arias, N., Arboleya, S., Allison, J., Kaliszewska, A., Higarza, S. G., Gueimonde, M., & Arias, J. L. (2020) · Nutrients · doi:10.3390/nu12082340 · Cited by 210
Gut microbiota in atherosclerosis: focus on trimethylamine N‐oxide
Zhu, Y., Li, Q., & Jiang, H. (2020) · Apmis · doi:10.1111/apm.13038 · Cited by 210
Self-citationCarnitine in bacterial physiology and metabolism
Meadows, J. A., & Wargo, M. J. (2015) · Microbiology · doi:10.1099/mic.0.000080 · Cited by 192
Host-microbiome interactions: Gut-Liver axis and its connection with other organs
Anand, S., & Mande, S. S. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00352-6 · Cited by 201
Lyu, M., Wang, Y., Fan, G., Wang, X., Xu, S.-Y., & Zhu, Y. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02146 · Cited by 197
Self-citationSkye, S. M., Zhu, W., Romano, K. A., Guo, C.-J., Wang, Z., Jia, X., Kirsop, J., Haag, B., Lang, J. M., DiDonato, J. A., et al. (2018) · Circulation Research · doi:10.1161/circresaha.118.313142 · Cited by 189
Streptomyces exploration is triggered by fungal interactions and volatile signals
Jones, S. E., Ho, L., Rees, C. A., Hill, J. E., Nodwell, J. R., & Elliot, M. A. (2017) · eLife · doi:10.7554/elife.21738 · Cited by 195
Canyelles, M., Tondo, M., Cedó, L., Farràs, M., Escolá‐Gil, J. C., & Blanco‐Vaca, F. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103228 · Cited by 197
Microbiology Meets Big Data: The Case of Gut Microbiota–Derived Trimethylamine
Falony, G., Vieira-Silva, S., & Raes, J. (2015) · Annual Review of Microbiology · doi:10.1146/annurev-micro-091014-104422 · Cited by 187
The germ-organ theory of non-communicable diseases
Byndloss, M. X., & Bäumler, A. J. (2018) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.158 · Cited by 195
Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease
Thomas, M. S., & Fernández, M. L. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00910-x · Cited by 192
Heianza, Y., Sun, D., Li, X., DiDonato, J. A., Bray, G. A., Sacks, F. M., & Qi, L. (2019) · Gut · doi:10.1136/gutjnl-2018-316155 · Cited by 177
Cai, Y., Huang, F., Lao, X., Lu, Y., Gao, X. J., Alolga, R. N., Yin, K., Zhou, X., Wang, Y., Liu, B., et al. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00273-4 · Cited by 184
Fu, B. C., Hullar, M. A. J., Randolph, T. W., Franke, A. A., Monroe, K. R., Cheng, I. C., Wilkens, L. R., Shepherd, J., Madeleine, M. M., Marchand, L. L., et al. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa015 · Cited by 177
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Li, X. S., Wang, Z., Čajka, T., Buffa, J. A., Nemet, I., Hurd, A. G., Gu, X., Skye, S. M., Roberts, A. B., Wu, Y., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.99096 · Cited by 167
Psychotropics and the Microbiome: a Chamber of Secrets…
Cussotto, S., Clarke, G. A., Dinan, T. G., & Cryan, J. F. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5185-8 · Cited by 176
Gut microbes impact stroke severity via the trimethylamine N-oxide pathway
Zhu, W., Romano, K. A., Li, L., Buffa, J. A., Sangwan, N., Prakash, P., Tittle, A. N., Li, X. S., Fu, X., Androjna, C., et al. (2021) · Cell Host & Microbe · doi:10.1016/j.chom.2021.05.002 · Cited by 167
Wu, W., Chen, C., Liu, P., Panyod, S., Liao, B., Chen, P.-C., Kao, H., Kuo, H., Kuo, C., Chiu, T. H. T., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317155 · Cited by 156
Microbiome, trimethylamine N-oxide, and cardiometabolic disease
Tang, W. H. W., & Hazen, S. L. (2017) · Translational Research · doi:10.1016/j.trsl.2016.07.007 · Cited by 160
New insights into the mechanisms of high‐fat diet mediated gut microbiota in chronic diseases
Chen, J., Xiao, Y., Li, D., Zhang, S., Wu, Y., Zhang, Q., & Bai, W. (2023) · iMeta · doi:10.1002/imt2.69 · Cited by 178
Li, X., Su, C., Jiang, Z., Yang, Y., Zhang, Y., Yang, M., Zhang, X., Du, Y., Zhang, J., Wang, L., et al. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-021-00205-8 · Cited by 155
Gut dysbiosis: Ecological causes and causative effects on human disease
Winter, S., & Bäumler, A. J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316579120 · Cited by 160
Skagen, K., Trøseid, M., Ueland, T., Holm, S., Abbas, A., Gregersen, I., Kummen, M., Bjerkeli, V., Reier-Nilsen, F., Russell, D., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.033 · Cited by 139
Defining the metabolic requirements for the growth and colonization capacity of Campylobacter jejuni
Hofreuter, D. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00137 · Cited by 151
Genomics and metagenomics of trimethylamine-utilizing Archaea in the human gut microbiome
Borrel, G., McCann, A., Deane, J., Neto, M. C., Lynch, D. B., Brugère, J., & O’Toole, P. W. (2017) · The ISME Journal · doi:10.1038/ismej.2017.72 · Cited by 137
Muralitharan, R. R., Jama, H. A., Xie, L., Peh, A., Snelson, M., & Marques, F. Z. (2020) · Hypertension · doi:10.1161/hypertensionaha.120.14473 · Cited by 131
Lucidi, M., Visaggio, D., Migliaccio, A., Capecchi, G., Visca, P., Imperi, F., & Zarrilli, R. (2023) · Virulence · doi:10.1080/21505594.2023.2289769 · Cited by 130
Rahim, M. B. H. A., Chilloux, J., Martínez-Gili, L., Neves, A. L., Myridakis, A., Gooderham, N. J., & Dumas, M. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01312-x · Cited by 127
Sánchez‐Alcoholado, L., Castellano‐Castillo, D., Jordán-Martínez, L., Moreno‐Indias, I., Cardila-Cruz, P., Elena-Aldana, D. J., Muñoz-García, A. J., Queipo‐Ortuño, M. I., & Jiménez-Navarro, M. F. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01936 · Cited by 115
Sánchez‐Alcoholado, L., Ordóñez, R., Otero, A. P., Plaza-Andrades, I. J., Laborda-Illanes, A., Medina, J. A., Ramos‐Molina, B., Gómez‐Millán, J., & Queipo‐Ortuño, M. I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186782 · Cited by 120
Buffa, J. A., Romano, K. A., Copeland, M. F., Cody, D. B., Zhu, W., Galvez, R., Fu, X., Ward, K., Ferrell, M., Dai, H. J., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-01010-x · Cited by 115
Lidbury, I. D. E. A., Murrell, J. C., & Chen, Y. (2014) · The ISME Journal · doi:10.1038/ismej.2014.149 · Cited by 112
Self-citationSimó, C., & García‐Cañas, V. (2020) · Food & Function · doi:10.1039/d0fo01237h · Cited by 112
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 116
Luo, Y., Zhang, Y., Han, X., Yuan, Y., Zhou, Y., Gao, Y., Yu, H., Zhang, J., Shi, Y., Duan, Y., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104087 · Cited by 111
Volatile Compounds of Bacterial Origin: Structure, Biosynthesis, and Biological Activity
Веселова, М. А., Александрович, П. В., & Khmel, I. A. (2019) · Microbiology · doi:10.1134/s0026261719030160 · Cited by 110
Bergeron, N., Williams, P. T., Lamendella, R., Faghihnia, N., Grube, A., Li, X., Wang, Z., Knight, R. D., Jansson, J. K., Hazen, S. L., et al. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516004165 · Cited by 105
Gut Metabolite Trimethylamine-N-Oxide in Atherosclerosis: From Mechanism to Therapy
Wang, B., Qiu, J., Lian, J., Yang, X., & Zhou, J. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.723886 · Cited by 109
Chan, C. W. H., Law, B. M. H., Waye, M. M. Y., Chan, J. Y., So, W. K. W., & Chow, K. M. (2019) · Journal of Cancer · doi:10.7150/jca.31737 · Cited by 96
Kuka, J., Liepinsh, E., Makrecka-Kuka, M., Liepins, J., Cirule, H., Gustina, D., Loza, E., Zharkova-Malkova, O., Grinberga, S., Pugovics, O., et al. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.09.028 · Cited by 97
Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD)
Hemmati, M., Kashanipoor, S., Mazaheri, P., Alibabaei, F., Babaeizad, A., Asli, S., Mohammadi, S., Gorgin, A. H., Ghods, K., Yousefi, B., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121947 · Cited by 105
Diet-gut microbiota interactions on cardiovascular disease
Zhang, X., & Gérard, P. (2022) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2022.03.028 · Cited by 98
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Gut and obesity/metabolic disease: Focus on microbiota metabolites
Lin, K., Zhu, L., & Li, Y. (2022) · MedComm · doi:10.1002/mco2.171 · Cited by 99
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Li, D. Y., & Tang, W. H. W. (2017) · Current Atherosclerosis Reports · doi:10.1007/s11883-017-0675-9 · Cited by 90
Lakshmi, G. B. V. S., Yadav, A. K., Mehlawat, N., Jalandra, R., Solanki, P. R., & Kumar, A. (2021) · Scientific Reports · doi:10.1038/s41598-020-80122-6 · Cited by 88
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Yoo, J. Y., Sniffen, S. E., Percy, K. C. M., Chidipi, B., & Pallaval, V. B. (2022) · Microorganisms · doi:10.3390/microorganisms10010108 · Cited by 88
Org, E., Mehrabian, M., & Lusis, A. J. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.05.035 · Cited by 85
Zhou, Y., Zhang, Y., Jin, S., Lv, J., Li, M., & Feng, N. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117031 · Cited by 94
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Sun, J., Mausz, M. A., Chen, Y., & Giovannoni, S. J. (2018) · Environmental Microbiology · doi:10.1111/1462-2920.14461 · Cited by 84
Self-citationInteraction between gut microbiota and ethnomedicine constituents
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Pérez, M. M., Martins, L. M. S., Dias, M. S., Pereira, C. A., Leite, J. A., Gonçalves, E. C. S., de Almeida, P. Z., de Freitas, E. N., Tostes, R. C., Ramos, S. G., et al. (2018) · Immunology · doi:10.1111/imm.13028 · Cited by 77
Farhangi, M. A., Vajdi, M., & Asghari-Jafarabadi, M. (2020) · Nutrition Journal · doi:10.1186/s12937-020-00592-2 · Cited by 72
Corrie, L., Awasthi, A., Kaur, J., Vishwas, S., Gulati, M., Kaur, I. P., Gupta, G., Kommineni, N., Dua, K., & Singh, S. K. (2023) · Pharmaceuticals · doi:10.3390/ph16020197 · Cited by 76
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Jameson, E., Doxey, A. C., Airs, R. L., Purdy, K. J., Murrell, J. C., & Chen, Y. (2016) · Microbial Genomics · doi:10.1099/mgen.0.000080 · Cited by 75
Self-citation
Metadata
- Authors
- Zhu, Y., Jameson, E., Crosatti, M., Schäfer, H., Rajakumar, K., Bugg, T. D. H., & Chen, Y.
- Affiliations
- School of Life Sciences and
- University of Leicester (GB)
- University of Warwick (GB)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-03-03
- Volume
- 111
- Issue
- 11
- Pages
- 4268-4273
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3964110
- OpenAlex
- W2000670099
- Cited by
- 372
- References
- 58
- Citations by year
- 2026: 22 · 2025: 35 · 2024: 46 · 2023: 36 · 2022: 44 · 2021: 47 · 2020: 36 · 2019: 22 · 2018: 29 · 2017: 14 · 2016: 16 · 2015: 17 · 2014: 7
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Royal Society
- Natural Environment Research Council (NE/I027061/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Polyamine Metabolism and Applications
- Keywords
- carnitine metabolism, trimethylamine, human gut microbiome, Acinetobacter baumannii, heterologous expression, trimethylamine N-oxide, cardiovascular disease, flavin-containing monooxygenase, gene clusters
- MeSH terms
- Carnitine, Chromatography, Ion Exchange, Escherichia coli, Humans, Methylamines, Oxidoreductases, Oxygenases, Spectrophotometry, Ultraviolet, Mutagenesis, Site-Directed, Computational Biology, Acinetobacter baumannii, Microbiota
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