The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
High-throughput sequencing reveals inbreeding depression in a natural population
Open accessAbstract
Significance: Many studies of wild populations reveal links between heterozygosity and fitness, with relatively heterozygous individuals carrying fewer parasites, living longer and being more attractive to mates. These patterns appear ubiquitous and are often highly significant, but heterozygosity usually accounts for very little of the total variation in fitness. However, most studies analyze only around 10 loci, representing a tiny fraction of the genome. We therefore used high-throughput DNA sequencing to estimate genome-wide heterozygosity based on over 10,000 loci and found it to accurately reflect inbreeding. Applied to wild harbor seals, genome-wide heterozygosity explained almost half of the variation in parasite infection. By implication, a greater proportion of fitness variation could be linked to genotype than previously thought.
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Cites
Male-male competition magnifies inbreeding depression in wild house mice.
Meagher, S., Penn, D. J., & Potts, W. K. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3324 · Cited by 322
Cited by
Runs of homozygosity: windows into population history and trait architecture
Ceballos, F. C., Joshi, P. K., Clark, D. W., Ramsay, M., & Wilson, J. F. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.109 · Cited by 1,006
Understanding Inbreeding Depression, Purging, and Genetic Rescue
Hedrick, P. W., & Garcia-Dorado, A. (2016) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2016.09.005 · Cited by 668
Fischer, M. C., Rellstab, C., Leuzinger, M., Roumet, M., Gugerli, F., Shimizu, K. K., Holderegger, R., & Widmer, A. (2017) · BMC Genomics · doi:10.1186/s12864-016-3459-7 · Cited by 283
Conservation and the Genomics of Populations
Allendorf, F. W., Funk, W. C., Aitken, S. N., Byrne, M., Luikart, G., & Antunes, A. (2022) · doi:10.1093/oso/9780198856566.001.0001 · Cited by 207
Noninvasive Sampling Reveals Short-Term Genetic Rescue in an Insular Red Fox Population
Quinn, C. B., Alden, P. B., & Sacks, B. N. (2019) · Journal of Heredity · doi:10.1093/jhered/esz024 · Cited by 34
Metadata
- Authors
- Hoffman, J. I., Simpson, F., David, P., Rijks, J. M., Kuiken, T., Thorne, M. A. S., Lacy, R. C., & Dasmahapatra, K. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-02-28
- Volume
- 111
- Issue
- 10
- Pages
- 3775-3780
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2118486822
- Cited by
- 326
- References
- 1
- FWCI
- 21.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Hoffman, J. I., Simpson, F., David, P., Rijks, J. M., Kuiken, T., Thorne, M. A. S., Lacy, R. C., & Dasmahapatra, K. K. (2014). High-throughput sequencing reveals inbreeding depression in a natural population. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1318945111
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