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Autosis is a Na + ,K + -ATPase–regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia–ischemia
Open accessAbstract
Significance: We show that the selective overactivation of autophagy can cause cell death with unique morphological features distinct from apoptosis or necrosis. This unique type of autophagic cell death, termed “autosis,” occurs not only in vitro but also in vivo in cerebral hypoxia–ischemia. Moreover, autosis is inhibited both in vitro and in vivo by cardiac glycosides, which are Na + ,K + -ATPase antagonists used in clinical medicine. Our findings contribute to the basic understanding of cell-death mechanisms and suggest strategies for protecting cells against stresses such as hypoxia–ischemia.
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“Corroborating the physiological relevance of this process, the administration of Na+/K+-ATPase inhibitors such as cardiac glycosides, confers neuroprotection in a rat model of neonatal hypoxia-ischemia [851].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [851]
In the citing paper
“Autosis is a specific variant of autophagy-dependent cell death that relies on the plasma membrane Na+/K+-ATPase [851].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [851]
In the citing paper
“On the one hand, RCD constitutes a primary etiological determinant in diseases associated with the irreversible loss of post-mitotic tissues (e.g., myocardial infarction, neurodegeneration) [687, 752, 851, 869, 1035, 1036].”
From Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. (2018) · cites this paper as [851]
In the citing paper
“We found that GC reduced the autophagic gene expression including key genes associated with autophagy induction, such as Atg7 and Beclin 1[45], by 1-5 folds”
From Prevention of glucocorticoid induced bone changes with beta-ecdysone (2015) · cites this paper as [45]
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Citations
Cites
Autophagy in the Pathogenesis of Disease
Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069
Self-citationGalluzzi, L., Vitale, I., Abrams, J. M., Alnemri, E. S., Baehrecke, E. H., Blagosklonny, M. V., Dawson, T. M., Dawson, V. L., El-Deiry, W. S., Fulda, S., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.96 · Cited by 2,421
Self-citationDevelopmental cell death: morphological diversity and multiple mechanisms
Clarke, P. H. (1990) · Anatomy and Embryology · doi:10.1007/bf00174615 · Cited by 1,695
Self-citationAutophagy in cell death: an innocent convict?
Levine, B. (2005) · Journal of Clinical Investigation · doi:10.1172/jci26390 · Cited by 1,694
Self-citationMatsui, Y., Takagi, H., Qu, X., Abdellatif, M., Sakoda, H., Asano, T., Levine, B., & Sadoshima, J. (2007) · Circulation Research · doi:10.1161/01.res.0000261924.76669.36 · Cited by 1,505
Self-citationIdentification of a candidate therapeutic autophagy-inducing peptide
Shoji-Kawata, S., Sumpter, R., Leveno, M., Campbell, G. R., Zou, Z., Kinch, L., Wilkins, A. D., Sun, Q., Pallauf, K., MacDuff, D., et al. (2013) · Nature · doi:10.1038/nature11866 · Cited by 760
Self-citationApoptosis, autophagy, and more
Lockshin, R. A., & Zakeri, Z. F. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.04.011 · Cited by 713
Novel therapeutic applications of cardiac glycosides
Prassas, I., & Diamandis, E. P. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2682 · Cited by 673
Cardiac Glycosides as Novel Cancer Therapeutic Agents
Newman, R. A., Yang, P., Pawlus, A. D., & Block, K. I. (2008) · Molecular Interventions · doi:10.1124/mi.8.1.8 · Cited by 517
Mechanisms of Autophagosome Biogenesis
Rubinsztein, D. C., Shpilka, T., & Elazar, Z. (2012) · Current Biology · doi:10.1016/j.cub.2011.11.034 · Cited by 517
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Allemailem, K. S., Almatroudi, A., Alrumaihi, F., Almatroodi, S. A., Alkurbi, M. O., Basfar, G. T., Rahmani, A. H., & Khan, A. A. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s321343 · Cited by 53
Dying neurons in thalamus of asphyxiated term newborns and rats are autophagic
Ginet, V., Pittet, M. P., Rummel, C., Osterheld, M. C., Meuli, R., Clarke, P. G. H., Puyal, J., & Truttmann, A. C. (2014) · Annals of Neurology · doi:10.1002/ana.24257 · Cited by 49
Self-citationAkkoç, Y., & Gözüaçık, D. (2018) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2018.150318 · Cited by 52
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Saito, T., Hamano, K., & Sadoshima, J. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa340 · Cited by 50
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Obradovic, M. M., Sudar-Milovanovic, E. M., Gluvic, Z. M., Banjac, K., Rizzo, M., & Isenović, E. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150171 · Cited by 56
“Recent research reveals an important role of Na/K-ATPase in autosis, that is characterized as an autophagy-dependent non-apoptotic form of cell death in different (125, 126).”
BackgroundTuz, A. A., Ghosh, S., Karsch, L., Ttoouli, D., Sata, S. P., Ulusoy, Ö., Kraus, A., Hoerenbaum, N., Wolf, J.-N., Lohmann, S., et al. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00462-8 · Cited by 50
Beauchamp, R. L., James, M. F., DeSouza, P., Wagh, V., Zhao, W., Jordan, J. T., Stemmer-Rachamimov, A. O., Plotkin, S. R., Gusella, J. F., Haggarty, S. J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4858 · Cited by 51
“Further studies are necessary to understand whether cell death mechanisms [34] are induced upon treatment with AZD2014.”
BackgroundConnexins: substrates and regulators of autophagy
Iyyathurai, J., Decuypere, J.-P., Leybaert, L., D’hondt, C., & Bultynck, G. (2016) · BMC Cell Biology · doi:10.1186/s12860-016-0093-9 · Cited by 52
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Spetz, J. K. E., Presser, A. G., & Sarosiek, K. A. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.07.004 · Cited by 55
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Galluzzi, L., Kepp, O., Zitvogel, L., Tang, D., & Kroemer, G. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.12.005 · Cited by 59
Edens, B. M., Miller, N., & Ma, Y. C. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00044 · Cited by 52
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Wolf, M. S., Bayır, H., Kochanek, P. M., & Clark, R. S. B. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.04.018 · Cited by 51
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Zhang, G., Luk, B. T., Wei, X., Campbell, G. R., Fang, R. H., Zhang, L., & Spector, S. A. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1661-7 · Cited by 50
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Alizadeh, J., Kavoosi, M., Singh, N., Lorzadeh, S., Ravandi, A., Kidane, B., Ahmed, N., Mraiche, F., Mowat, M. R. A., & Ghavami, S. (2023) · Cancers · doi:10.3390/cancers15082195 · Cited by 51
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Bootman, M. D., Allman, S. A., Rietdorf, K., & Bultynck, G. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.04.005 · Cited by 48
Singh, A. K., Singh, S., Tripathi, V., Bissoyi, A., Garg, G., & Rizvi, S. I. (2018) · Rejuvenation Research · doi:10.1089/rej.2018.2070 · Cited by 48
“81 The cholinergic neurotransmission disruption has also been shown in old age.”
Jeong, I.-H., Bae, W., Choi, J., & Jeong, J. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02849-4 · Cited by 49
O’Donovan, T. R., Rajendran, S., O’Reilly, S., O’Sullivan, G. C., & McKenna, S. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0134676 · Cited by 47
Autophagy and checkpoints for intracellular pathogen defense
Paulus, G. L. C., & Xavier, R. J. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000134 · Cited by 53
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Rana, S., Rajakumar, A., Geahchan, C., Salahuddin, S., Cerdeira, A. S., Burke, S. D., George, E. M., Granger, J. P., & Karumanchi, S. A. (2014) · The FASEB Journal · doi:10.1096/fj.14-252684 · Cited by 46
“It is also possible that the beneficial effects of ouabain in the placenta may be related to its effects on other pathways, such as blocking autophagy-mediated cell death or “autosis” that was recently described to occur in stressful situations (38).”
BackgroundAutosis occurs in the liver of patients with severe anorexia nervosa
Kheloufi, M., Boulanger, C. M., Codogno, P., & Rautou, P. (2014) · Hepatology · doi:10.1002/hep.27597 · Cited by 46
“D.(1,3) (1)INSERM UMR-S970 Universit e Paris Descartes Sorbonne Paris Cit e Paris, France (2)INSERM U1151 Institut Necker Enfants-Malades-INEM Paris, France (3)DHU Unity Service d’H epatologie Hôpital Beaujon Assistance Publique-Hôpitaux de Paris Clichy, France”
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Xiao, S., Peng, K., Li, C.-L., Long, Y., & Yu, Q. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01681-x · Cited by 49
“Nevertheless, autophagy can promote cell apoptosis and necrosis in speci fi c instances [31].”
BackgroundThe role of the Hippo pathway in autophagy in the heart
Maejima, Y., Zablocki, D., Nah, J., & Sadoshima, J. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac014 · Cited by 45
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BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins
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Feng, J., Chen, X., & Shen, J. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1281250 · Cited by 45
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BackgroundInfluentialHan, S., Li, X., Wang, K., Zhu, D., Meng, B., Liu, J., Liang, X., Jin, Y., Liu, X., Wen, Q., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04362-8 · Cited by 44
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Villa, E., & Ricci, J. (2015) · FEBS Journal · doi:10.1111/febs.13570 · Cited by 42
Deretic, V. P. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.4mr0216-079r · Cited by 43
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Flynn, A. L. B., & Schiemann, W. P. (2019) · Journal of Cancer Metastasis and Treatment · doi:10.20517/2394-4722.2019.13 · Cited by 41
Chen, Y., & Gibson, S. B. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166265 · Cited by 40
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BackgroundAutophagy as a Homeostatic Mechanism in Response to Stress Conditions in the Central Nervous System
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Arnaud-Sampaio, V. F., Rabelo, I. L. A., Ulrich, H., & Lameu, C. (2019) · Stem Cell Reviews and Reports · doi:10.1007/s12015-019-09936-w · Cited by 41
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Yu, J. G., & Wang, J. (2020) · Biochimie · doi:10.1016/j.biochi.2020.11.002 · Cited by 39
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Muñoz‐Pinedo, C., & Martin, S. J. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.246 · Cited by 42
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Ploumi, C., Papandreou, M.-E., & Tavernarakis, N. (2022) · Biochemical Journal · doi:10.1042/bcj20210450 · Cited by 39
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Thévenod, F., & Lee, W. (2015) · Toxics · doi:10.3390/toxics3020130 · Cited by 42
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Truttmann, A. C., Ginet, V., & Puyal, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00027 · Cited by 38
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BackgroundSelf-citationChen, C., Dai, G., Fan, M., Wang, X., Niu, K., & Gao, W. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06262-3 · Cited by 45
“One plausible mechanism is that autophagy during I/R may induce autosis in cardiomyocytes [126].”
Role of NADPH oxidase in the regulation of autophagy in cardiomyocytes
Sciarretta, S., Yee, D., Ammann, P. B., Nagarajan, N., Volpe, M., Frati, G., & Sadoshima, J. (2014) · Clinical Science · doi:10.1042/cs20140336 · Cited by 36
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Maejima, Y., Chen, Y., Isobe, M., Gustafsson, Å. B., Kitsis, R. N., & Sadoshima, J. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00711.2014 · Cited by 38
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Nah, J., Sung, E., Zhai, P., Zablocki, D., & Sadoshima, J. (2022) · Cells · doi:10.3390/cells11020258 · Cited by 38
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“In this regard it has been shown that cells can undergo ‘autophagy-mediated’ cell death, autosis, which is distinct both molecularly and morphologically from necrosis and apoptosis.(40) In particular, autosis is inducible through starvation,(40) indicating that this response may provide an alternative cell-death pathw…”
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“Remarkably, these authors propose the term ‘autosis’, first coined by Liu et al. (2013) to indicate a form of ATG cell death with “unique morphological features, including increased autophagosomes/autolysosomes . . . , which occurs during treatment with autophagy-inducing peptides, starvation, and…”
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Quarleri, J. F., Cevallos, C. G., & Delpino, M. V. (2021) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2021.01.001 · Cited by 39
Zi, Z., Song, Z., Zhang, S., Ye, Y., Li, C., Xu, M., Zou, Y., He, L., & Zhu, H. (2014) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000188 · Cited by 36
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Heath, B. R., Gong, W., Taner, H. F., Broses, L. J., Okuyama, K., Cheng, W., Jin, M., Fitzsimonds, Z. R., Manousidaki, A., Wu, Y., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112303 · Cited by 38
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Zhu, M., Li, Y., Xu, Q., Wang, W., Liu, Y., & Liu, Y. (2025) · MedComm · doi:10.1002/mco2.70418 · Cited by 49
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Raha, S., Kim, S. M., Lee, H. J., Yumnam, S., Saralamma, V. V. G., Ha, S. E., Lee, W. S., & Kim, G. S. (2020) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x20500342 · Cited by 36
Kryvenko, V., & Vadász, I. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00056.2021 · Cited by 34
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Does Autophagy Mediate Cardiac Myocyte Death During Stress?
Nah, J., Fernández, Á. F., Kitsis, R. N., Levine, B., & Sadoshima, J. (2016) · Circulation Research · doi:10.1161/circresaha.116.309765 · Cited by 36
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Velentzas, P. D., Zhang, L., Das, G., Chang, T.-K., Nelson, C., Kobertz, W. R., & Baehrecke, E. H. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.09.015 · Cited by 31
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BackgroundSelf-citationHu, Y., Wang, Z., Liu, Y., Pan, S., Zhang, H., Fang, M., Jiang, H., Yin, J., Zou, S., Li, Z., et al. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.050 · Cited by 33
Self-citationDying to protect: cell death and the control of T‐cell homeostasis
Li, K., Shanmuganad, S., Carroll, K. R., Katz, J. D., Jordan, M. B., & Hildeman, D. A. (2017) · Immunological Reviews · doi:10.1111/imr.12538 · Cited by 34
Loh, K. Y., Wang, Z., & Liao, P. H. (2018) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/112_2018_13 · Cited by 34
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Romano, P. S., Akematsu, T., Besteiro, S., Bindschedler, A., Carruthers, V. B., Chahine, Z. M., Coppens, I., Descoteaux, A., Duque, T. L. A., He, C. Y., et al. (2023) · Autophagy Reports · doi:10.1080/27694127.2022.2149211 · Cited by 33
Fernandes, M. G. F., Luo, J. X. X., Cui, Q., Perlman, K., Pernin, F., Yaqubi, M., Hall, J. A., Dudley, R., Srour, M., Couturier, C., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01557-1 · Cited by 36
Ion Channels and Transporters in Autophagy
Zhang, R., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2021.1885147 · Cited by 33
How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives
Corsetti, G., Pasini, E., Romano, C., Chen-Scarabelli, C. A., Scarabelli, T. M., Flati, V., Saravolatz, L. I. I., & Dioguardi, F. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073332 · Cited by 33
“This situation was recently named autosis [63].”
Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology
Zhu, M., Sun, H., Cao, L., Wu, Z., Leng, B., & Bian, J. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02143-6 · Cited by 33
“A novel study published in 2013 defined an autophagy-dependent cell death named “autosis” in HeLa cells and proved to require NKAα1 exclusively [13].”
BackgroundInfluentialLiu, H., Yan, J., Guan, F., Jin, Z., Xie, J., Wang, C., Liu, M., & Liu, J. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2023.159287 · Cited by 33
Yang, C., Zhang, X., Gao, J., Wang, M., & Yang, Z. R. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.121 · Cited by 36
Zhang, G., Luk, B. T., Hamidy, M., Zhang, L., & Spector, S. A. (2018) · Autophagy · doi:10.1080/15548627.2018.1476014 · Cited by 33
“A selective form of autophagy leading to cell death has been identified by the Levine laboratory, termed autosis, which is dependent on the induction of Na/K-ATPase [26,27].”
BackgroundSelf-citationNa+/K+-ATPase-dependent autophagy protects brain against ischemic injury
Zhu, M., Cao, L., Xiong, S., Sun, H., Wu, Z., & Bian, J.-S. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0153-7 · Cited by 32
Shu, Y., Yuan, H., Xu, M., Hong, Y., Gao, C., Wu, Z., Han, H., Sun, X., Gao, R.-L., Yang, S.-F., et al. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0492-5 · Cited by 33
Small Molecules Targeting Programmed Cell Death in Breast Cancer Cells
Maniam, S., & Maniam, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189722 · Cited by 33
Cell Death and Survival Pathways Involving ATM Protein Kinase
Aki, T., & Uemura, K. (2021) · Genes · doi:10.3390/genes12101581 · Cited by 33
“There are other forms of regulated cell death such as pyroptosis [93], autosis [94], and methuosis [95], and we should also pay attention to the possible involvement of ATM in these cell deaths.”
BackgroundGenetic control of autophagy underlies pathogenesis of inflammatory bowel disease
Lassen, K. G., & Xavier, R. J. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.18 · Cited by 32
“Autophagy is often considered a prosurvival mechanism with many benefits; however, prolonged, uncontrolled autophagy can lead to a type of cell death termed autosis.(2) Therefore, the induction of autophagy and sustained autophagy must be regulated through both transcriptional and post-translational mechanisms.”
BackgroundSelf-citationClec16a is Critical for Autolysosome Function and Purkinje Cell Survival
Redmann, V., Lamb, C. A., Hwang, S., Orchard, R. C., Kim, S., Razi, M., Milam, A., Park, S., Yokoyama, C. C., Kambal, A., et al. (2016) · Scientific Reports · doi:10.1038/srep23326 · Cited by 31
Mitophagy in cardiovascular homeostasis
Zhang, R., Krigman, J., Luo, H., Ozgen, S., Yang, M., & Sun, N. (2020) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111245 · Cited by 31
“In addition, under some conditions, uncontrolled or excessive mitophagy may be detrimental (Liu et al., 2013; Saito and Sadoshima, 2015).”
BackgroundEpigenetic inactivation of the autophagy–lysosomal system in appendix in Parkinson’s disease
Gordevičius, J., Li, P., Marshall, L. L., Killinger, B. A., Lang, S., Ensink, E., Kuhn, N. C., Cui, W., Maroof, N., Lauria, R., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25474-x · Cited by 36
Fukushima, K., Kitamura, S., Tsuji, K., & Wada, J. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.761842 · Cited by 31
“In addition, in the mouse model of myocardial ischemia–reperfusion (I/R) injury, excessive autophagy is reported to cause the autophagic cell death of myocardial cells in the reperfusion phase (Liu et al., 2013).”
BackgroundPrevention of glucocorticoid induced bone changes with beta-ecdysone
Dai, W., Jiang, L., Lay, Y.-A. E., Chen, H., Jin, G., Zhang, H., Kot, A., Ritchie, R. O., Lane, N. E., & Yao, W. (2015) · Bone · doi:10.1016/j.bone.2015.01.001 · Cited by 30
“We found that GC reduced the autophagic gene expression including key genes associated with autophagy induction, such as Atg7 and Beclin 1 [45], by 1–5 folds while co-treatment ofβEcd activated these autophagic gene expressions by 5–10 folds (Fig.”
Choi, Y. B., Choi, Y., & Harhaj, E. W. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1007058 · Cited by 30
Camuzard, O., Trojani, M.-C., Santucci‐Darmanin, S., Pagnotta, S., Breuil, V., Carle, G. F., & Pierrefite‐Carle, V. (2020) · Cancers · doi:10.3390/cancers12123675 · Cited by 32
“To date, this cell death has only been observed in cases of hypoxia-ischemia in mice brain [31], in mouse kidneys subjected to ischemia-reperfusion [38] and during cardiac ischemia-reperfusion [33].”
BackgroundInfluentialCardiac Glycosides as Autophagy Modulators
Škubník, J., Pavlíčková, V. S., Psotová, J., & Rimpelová, S. (2021) · Cells · doi:10.3390/cells10123341 · Cited by 33
“[57] in 2013 and it represents a unique mode of cell death characterized not only by an increase in autophagosomes, but also by ER dilation followed by later depletion, early-stage nuclear convolution, and late-stage focal swelling of the perinuclear space.”
BackgroundThe role of autophagic cell death in cardiac disease
Nah, J., Zablocki, D., & Sadoshima, J. (2022) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2022.08.362 · Cited by 30
Sickness-Associated Anorexia: Mother Nature’s Idea of Immunonutrition?
van Niekerk, G., Isaacs, A. W., Nell, T. A., & Engelbrecht, A. (2016) · Mediators of Inflammation · doi:10.1155/2016/8071539 · Cited by 32
“In this regard, autophagy-mediated cell death (autosis) [91] may provide a “backup” cell death programme.”
BackgroundDing, G., Sun, J., Wu, G., Li, B.-C., Yang, P., Li, Z., & Nie, G. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b17454 · Cited by 29
Feng, W., Wang, J., Yan, X., Zhai, C., Shi, W., Wang, Q., Zhang, Q., & Li, M. (2019) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-019-01615-4 · Cited by 28
Abdel-Mohsen, M. A., Malak, C. A. A., & El‐Shafey, E. S. (2019) · Advances in Medical Sciences · doi:10.1016/j.advms.2018.08.014 · Cited by 30
SIK2 Restricts Autophagic Flux To Support Triple-Negative Breast Cancer Survival
Maxfield, K., Macion, J., Vankayalapati, H., & Whitehurst, A. W. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00380-16 · Cited by 29
“It is possible that the unrestrained autophagy is leading to autolysis in sensitive cells (43).”
BackgroundATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A
Wan, X., Serrill, J., Humphreys, I., Tan, M. H., McPhail, K. L., Ganley, I. G., & Ishmael, J. E. (2018) · Marine Drugs · doi:10.3390/md16030077 · Cited by 30
“Previous studies have shown that a distinct form of autophagy-dependent, non-apoptotic cell death, termed autosis, can be induced by small synthetic peptides, which trigger death with morphological and biochemical characteristics that can be distinguished from apoptosis and other modes of cell death, such as necroptos…”
BackgroundZhu, E., Chen, W., Qin, Y., Ma, S., Fan, S., Wu, K., Li, W., Fan, J., Yi, L., Ding, H., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02545 · Cited by 28
“Furthermore, excessive or uncontrolled autophagy even can trigger a form of non-apoptotic cell death, termed “autosis,” which is dependent on the activity of Na+/ K+-ATPase and has unique morphological features (Liu et al., 2013; Liu and Levine, 2015).”
BackgroundIzadi, M., Ali, T. A., & Pourkarimi, E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212466 · Cited by 30
Metadata
- Authors
- Liu, Y., Shoji-Kawata, S., Sumpter, R. M., Wei, Y., Ginet, V., Zhang, L., Posner, B., Tran, K. A., Green, D. R., Xavier, R. J., Shaw, S. Y., Clarke, P. G. H., Puyal, J., & Levine, B.
- Affiliations
- Center for Autophagy Research,
- Howard Hughes Medical Institute (US)
- University of Lausanne (CH)
- Biochemistry, and
- Center for Systems Biology (US)
- St. Jude Children's Research Hospital (US)
- Broad Institute (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-11-25
- Volume
- 110
- Issue
- 51
- Pages
- 20364-20371
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3870705
- OpenAlex
- W2145084709
- Cited by
- 607
- References
- 35
- Citations by year
- 2026: 33 · 2025: 48 · 2024: 38 · 2023: 51 · 2022: 46 · 2021: 58 · 2020: 50 · 2019: 51 · 2018: 43 · 2017: 58 · 2016: 47 · 2015: 43 · 2014: 38
- FWCI
- 31.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (acceptedVersion, other-oa)
- IRIS (submittedVersion)
- Funders
- National Science Foundation (310030)
- Howard Hughes Medical Institute
- McKnight Foundation
- University of Texas Southwestern Medical Center
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (130769, 310030)
- Université de Lausanne
- National Institutes of Health (HHSN268201000044C, 5p01ca095471-10, 1P01CA95471-09)
- U.S. Public Health Service (R01 A140646)
- National Heart, Lung, and Blood Institute (HHSN268201000044C)
- National Cancer Institute (P01 CA95471, P01-CA095471, R01CA169291, CA109618, HHSN268201000044C, (CA142543), R01CA109618, P30CA142543)
- National Institute of Allergy and Infectious Diseases (R01AI040646, U54AI057156)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
- Keywords
- autophagic cell death, Na+/K+-ATPase, Beclin-1, starvation, hypoxia-ischemia, hippocampal neurons, cardiac glycosides, Na+/K+-ATPase alpha1 subunit, autophagosomes, cell death regulation
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Animals, Autophagy, Cardiac Glycosides, Brain Ischemia, HeLa Cells, Humans, Nerve Tissue Proteins, Rats, Cell-Penetrating Peptides
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