Inositol Polyphosphate Multikinase Is a Coactivator for Serum Response Factor-Dependent Induction of Immediate Early Genes
Open accessAbstract
Significance: The inositol polyphosphate system is a major intracellular signaling modality. Inositol polyphosphate multikinase (IPMK) is essential for this system, converting inositol 1,4,5-trisphosphate (IP3) to IP4 and IP4 to IP5. IPMK also is a physiologic PI3-kinase. In a noncatalytic manner, IPMK stabilizes the mammalian target of rapamycin (mTOR) complex as well as tumor suppressor protein p53 and CREB-binding protein (CBP)/E1A binding protein p300. We now demonstrate that IPMK is a transcriptional coactivator for serum response factor (SRF) signaling, which is markedly reduced in IPMK-deleted mice and augmented by IPMK overexpression. IPMK binds directly to SRF, facilitating its interaction with serum response elements of multiple immediate early genes. Agents influencing IPMK interactions with SRF may be useful in regulating the SRF signaling system.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mammalian IPMK acts as a transcriptional co-activator of SRF, promoting gene transcription through physical interaction with SRF, independent of its kinase activity.
“Kim et al. [46] found that mammalian IPMK acts as a transcriptional co-activator of SRF, promoting gene transcription through physical interaction with SRF, independent of its kinase activity.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [46]
Cites
A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D. (2000) · Science · doi:10.1126/science.287.5460.2026 · Cited by 394 · see citing works
Saiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041614598 · Cited by 110 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease
Mishra, S. H., Chatterjee, S., Viera-Preval, L., & Guha, P. (2025) · Biomolecules · doi:10.3390/biom15091266 · Cited by 1 · see citing works
- Authors
- Kim, E., Tyagi, R., Lee, J.-Y., Park, J., Kim, Y.-R., Beon, J., Chen, P. Y., Cha, J. Y., Snyder, S. H., & Kim, S.
- Affiliations
- Korea Advanced Institute of Science and Technology (KR)
- The Solomon H. Snyder Department of Neuroscience,
- Department of Biological Sciences (RU)
- Johns Hopkins University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-11-18
- Volume
- 110
- Issue
- 49
- Pages
- 19938-19943
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3856792
- OpenAlex
- W2028716298
- Cited by
- 38
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 5 · 2017: 5 · 2016: 4 · 2015: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- inositol polyphosphate multikinase, serum response factor, transcriptional coactivator, immediate early genes, serum response element, transcriptional regulation
- MeSH terms
- Animals, Image Processing, Computer-Assisted, Immunoblotting, Signal Transduction, Transcriptional Activation, Tumor Suppressor Protein p53, Genes, Immediate-Early, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Mice, Knockout, Serum Response Factor, Microarray Analysis, Chromatin Immunoprecipitation, E1A-Associated p300 Protein, Mice, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
