A Role for Nuclear Inositol 1,4,5-Trisphosphate Kinase in Transcriptional Control
Abstract
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA export through production of inositol hexakisphosphate (IP 6 ). The inositol 1,4,5-trisphosphate kinase of this pathway in Saccharomyces cerevisiae , designated Ipk2, was found to be identical to Arg82, a regulator of the transcriptional complex ArgR-Mcm1. Synthesis of inositol 1,4,5,6-tetrakisphosphate, but not IP 6 , was required for gene regulation through ArgR-Mcm1. Thus, the phospholipase C pathway produces multiple IP messengers that modulate distinct nuclear processes. The results reveal a direct mechanism by which activation of IP signaling may control gene expression.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Odom et al. showed that Arg82 is an inositol phosphate kinase that converts Ins(1,4,5)P3 to Ins(1,4,5,6)P4 and that kinase activity is required for its role in transcriptional regulation.
“Odom et al showed that Arg82 is an inositol phosphate kinase that converts Ins(1,4,5)P3 to Ins(1,4,5,6)P4 and that kinase activity is required for its role in transcriptional regulation (figure 5d)36.”
From Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate (2012) · cites this paper as [36]
IPK2 enhances DNA binding of the ArgR-MCM1 complex independently of its kinase activity.
“This study revealed that IPK2 (yeast IPMK) enhances DNA binding of the ArgR-MCM1 complex independently of its kinase activity.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
The transcriptional function of ArgR-MCM1 is regulated by InsP4 and InsP5, which are products of IPK2's kinase activity.
“However, the transcriptional function of this complex is regulated by InsP4 and InsP5, which are products of IPK2’s kinase activity.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
InsP4 (Ins 1,4,5,6) is crucial for activating the ArgR-MCM1 transcription factor in yeast.
“The York group demonstrated that InsP4 (Ins 1, 4, 5, 6) is crucial for activating the ArgR-MCM1 transcription factor in yeast [73], which regulates genes involved in cell cycle, cell type specificity, and responses to pheromones and nutrients.”
From From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease (2025) · cites this paper as [73]
Cites
Inositol trisphosphate and calcium signalling
Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545 · see citing works
The MADS-Box Family of Transcription Factors
Shore, P., & Sharrocks, A. D. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.0001l.x · Cited by 898 · see citing works
The MADS-Box Family of Transcription Factors
Shore, P., & Sharrocks, A. D. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20430.x · Cited by 702 · see citing works
York, J. D., John, A. R. O., Murphy, R., Ives, E. B., & Wente, S. R. (1999) · Science · doi:10.1126/science.285.5424.96 · Cited by 547 · see citing works
Self-citationSaiardi, A., Erdjument-Bromage, H., Snowman, A. M., Tempst, P., & Snyder, S. H. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80055-x · Cited by 414 · see citing works
INOSITOL PHOSPHATE BIOCHEMISTRY
Majerus, P. W. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.001301 · Cited by 397 · see citing works
Boronenkov, I. V., Loijens, J. C., Umeda, M., & Anderson, R. A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.12.3547 · Cited by 337 · see citing works
Nuclear localization and signalling activity of phosphoinositidase Cβ in Swiss 3T3 cells
Martelli, A. M., Gilmour, R., Bertagnolo, V., Neri, L. M., Manzoli, L., & Cocco, L. (1992) · Nature · doi:10.1038/358242a0 · Cited by 322 · see citing works
The yeast cell-type-specific repressor α2 acts cooperatively with a non-cell-type-specific protein
Keleher, C. A., Goutte, C., & Johnson, A. D. (1988) · Cell · doi:10.1016/s0092-8674(88)90449-7 · Cited by 314 · see citing works
Significance of PIP2 hydrolysis and regulation of phospholipase C isozymes
Lee, S. B., & Rhee, S. G. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80026-3 · Cited by 290 · see citing works
Liu, Q., Li, M. Z., Leibham, D., Cortez, D., & Elledge, S. J. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00560-x · Cited by 282 · see citing works
Mutations Affecting the Repressibility of Arginine Biosynthetic Enzymes in Sacchromyces cerevisiae
Béchet, J., Grenson, M., & Wiame, J. M. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb00817.x · Cited by 242 · see citing works
Smith, C. D., & Wells, W. W. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44677-1 · Cited by 216 · see citing works
Inositides and the nucleus and inositides in the nucleus
Divecha, N., Banfíƈ, H., & Irvine, R. F. (1993) · Cell · doi:10.1016/0092-8674(93)80041-c · Cited by 208 · see citing works
Flick, J. S., & Thorner, J. W. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5861 · Cited by 192 · see citing works
Inositol phosphates: proliferation, metabolism and function
Irvine, R. F., Moor, R. M., Pollock, W. K., Smith, P. M., & WREGGETT, K. A. (1988) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1988.0077 · Cited by 190 · see citing works
The versatility of inositol phosphates as cellular signals
Shears, S. B. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00131-3 · Cited by 184 · see citing works
Yoko‐o, T., Matsui, Y., Yagisawa, H., Nojima, H., Uno, I., & Toh‐e, A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.5.1804 · Cited by 158 · see citing works
Phospholipid signalling in the nucleus
D’Santos, C. S., Clarke, J. H., & Divecha, N. (1998) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s0005-2760(98)00146-5 · Cited by 152 · see citing works
Molecular Cloning and Expression of a Complementary DNA for Inositol 1,4,5-Trisphosphate 3-Kinase
Choi, K. Y., Kim, H.-K., Lee, S. Y., Moon, K. H., Sim, S. S., Kim, J., Chung, H. K., & Rhee, S. G. (1990) · Science · doi:10.1126/science.2157285 · Cited by 140 · see citing works
A New Phospholipase C δ4 Is Induced at S-phase of the Cell Cycle and Appears in the Nucleus
Liu, N., Fukami, K., Yu, H., & Takenawa, T. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.355 · Cited by 123 · see citing works
Nuclear phosphatidylinositols decrease during S-phase of the cell cycle in HeLa cells.
York, J. D., & Majerus, P. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37126-0 · Cited by 119 · see citing works
Self-citationMULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION
Wolberger, C. (1999) · Annual Review of Biophysics and Biomolecular Structure · doi:10.1146/annurev.biophys.28.1.29 · Cited by 119 · see citing works
Dubois, E. L., Bercy, J., & Messenguy, F. (1987) · Molecular and General Genetics MGG · doi:10.1007/bf00331501 · Cited by 117 · see citing works
Stolz, L. E., Kuo, W. J., Longchamps, J., Sekhon, M. K., & York, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.19.11852 · Cited by 99 · see citing works
Self-citationPayne, W. E., & Fitzgerald‐Hayes, M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4351-4364.1993 · Cited by 96 · see citing works
Maher, M., Cong, F., Kindelberger, D. W., Nasmyth, K., & Dalton, S. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.6.3129 · Cited by 89 · see citing works
Messenguy, F., & Dubois, E. L. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2586-2592.1993 · Cited by 80 · see citing works
Phospholipase C-δ1 Contains a Functional Nuclear Export Signal Sequence
Yamaga, M., Fujii, M., Kamata, H., Hirata, H., & Yagisawa, H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.40.28537 · Cited by 69 · see citing works
Ongusaha, P. P., Hughes, P., Davey, J. F., & Michell, R. H. (1998) · Biochemical Journal · doi:10.1042/bj3350671 · Cited by 65 · see citing works
In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter.
Dubois, E., & Messenguy, F. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.4.2162 · Cited by 53 · see citing works
Rijcke, M. D., Seneca, S., Punyammalee, B., Glansdorff, N., & Crabeel, M. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.1.68-81.1992 · Cited by 53 · see citing works
Bercy, J., Dubois, E. L., & Messenguy, F. (1987) · Gene · doi:10.1016/0378-1119(87)90287-3 · Cited by 51 · see citing works
Dubois, E. L., & Messenguy, F. (1994) · Molecular and General Genetics MGG · doi:10.1007/bf00301067 · Cited by 46 · see citing works
Molecular study and regulation of d-myo-inositol 1,4,5-trisphosphate 3-kinase
Communi, D., Vanweyenberg, V., & Erneux, C. (1995) · Cellular Signalling · doi:10.1016/0898-6568(95)00035-n · Cited by 44 · see citing works
Inositol polyphosphate 1-phosphatase is present in the nucleus and inhibits DNA synthesis.
York, J. D., Saffitz, J. E., & Majerus, P. W. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32118-x · Cited by 35 · see citing works
Self-citationEstévez, F., Pulford, D. J., Stark, M. J. R., Carter, A. N., & Downes, C. P. (1994) · Biochemical Journal · doi:10.1042/bj3020709 · Cited by 29 · see citing works
Nucleus-associated phosphorylation of Ins(1,4,5)P3 to InsP6 in Dictyostelium
KAAY, J. V. D., Wesseling, J., & Haastert, P. J. M. V. (1995) · Biochemical Journal · doi:10.1042/bj3120911 · Cited by 23 · see citing works
Regulation of Nuclear Calcium Uptake by Inositol Phosphates and External Calcium
Hsu, A., Lu, P., & Chen, C.-S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8161 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638 · see citing works
Molecular views of recombination proteins and their control
West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 947 · see citing works
Signal Transduction Cascades Regulating Fungal Development and Virulence
Lengeler, K. B., Davidson, R. C., D'souza, C., Harashima, T., Shen, W.-C., Wang, P., Pan, X., Waugh, M., & Heitman, J. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.746-785.2000 · Cited by 915 · see citing works
Back in the Water: The Return of the Inositol Phosphates
Irvine, R. F., & Schell, M. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35073015 · Cited by 659 · see citing works
Auxin Receptors and Plant Development: A New Signaling Paradigm
Mockaitis, K., & Estelle, M. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123214 · Cited by 651 · see citing works
Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate
Watson, P. J., Fairall, L., Santos, G. M., & Schwabe, J. W. R. (2012) · Nature · doi:10.1038/nature10728 · Cited by 505 · see citing works
Genetic Basis of Mitochondrial Function and Morphology in Saccharomyces cerevisiae
Dimmer, K. S., Fritz, S., Fuchs, F., Messerschmitt, M., Weinbach, N., Neupert, W., & Westermann, B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0588 · Cited by 443 · see citing works
Irvine, R. F. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1100 · Cited by 403 · see citing works
Nuclear Actin and Actin-Related Proteins in Chromatin Remodeling
Olave, I. A., Reck‐Peterson, S. L., & Crabtree, G. R. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.110601.135507 · Cited by 395 · see citing works
Approaches and challenges to engineering seed phytate and total phosphorus
Raboy, V. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.06.012 · Cited by 385 · see citing works
Xiong, L., Lee, B., Ishitani, M., Lee, H., Zhang, C., & Zhu, J. (2001) · Genes & Development · doi:10.1101/gad.891901 · Cited by 367 · see citing works
Regulation of Chromatin Remodeling by Inositol Polyphosphates
Steger, D. J., Haswell, E. S., Miller, A. L., Wente, S. R., & O'Shea, E. K. (2003) · Science · doi:10.1126/science.1078062 · Cited by 352 · see citing works
Self-citationModulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Shen, X., Xiao, H., Ranallo, R., Wu, W.-H., & Wu, C. (2003) · Science · doi:10.1126/science.1078068 · Cited by 338 · see citing works
Generation of phytate-free seeds in Arabidopsis through disruption of inositol polyphosphate kinases
Stevenson, J. M., Bastidas, R. J., Chiou, S., Frye, R. A., & York, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504172102 · Cited by 322 · see citing works
Self-citationPIP5K-driven PtdIns(4,5) P 2 synthesis: regulation and cellular functions
van den Bout, I., & Divecha, N. (2009) · Journal of Cell Science · doi:10.1242/jcs.056127 · Cited by 312 · see citing works
Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export
Alcázar-Román, A. R., Tran, E. J., Guo, S., & Wente, S. R. (2006) · Nature Cell Biology · doi:10.1038/ncb1427 · Cited by 302 · see citing works
Self-citationMessenguy, F., & Dubois, E. L. (2003) · Gene · doi:10.1016/s0378-1119(03)00747-9 · Cited by 299 · see citing works
DeWald, D. B., Torabinejad, J., Jones, C. A., Shope, J. C., Cangelosi, A. R., Thompson, J. E., Prestwich, G. D., & Hama, H. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.759 · Cited by 290 · see citing works
A Conserved Family of Enzymes That Phosphorylate Inositol Hexakisphosphate
Mulugu, S., Bai, W., Fridy, P. C., Bastidas, R. J., Otto, J. C., Dollins, D. E., Haystead, T., Ribeiro, A. A., & York, J. D. (2007) · Science · doi:10.1126/science.1139099 · Cited by 286 · see citing works
Self-citationWeirich, C. S., Erzberger, J. P., Flick, J. S., Berger, J. M., Thorner, J. W., & Weis, K. (2006) · Nature Cell Biology · doi:10.1038/ncb1424 · Cited by 285 · see citing works
Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair
Hanakahi, L. A., Bartlet‐Jones, M., Chappell, C., Pappin, D., & West, S. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00061-1 · Cited by 263 · see citing works
Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder
Schloesser, R. J., Huang, J. Y., Klein, P. S., & Manji, H. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301575 · Cited by 256 · see citing works
Balla, T. (2005) · Journal of Cell Science · doi:10.1242/jcs.02387 · Cited by 248 · see citing works
Insights into the activation mechanism of class I HDAC complexes by inositol phosphates
Watson, P. J., Millard, C. J., Riley, A. M., Robertson, N. S., Wright, L. C., Godage, H. Y., Cowley, S. M., Jamieson, A. G., Potter, B. V. L., & Schwabe, J. W. R. (2016) · Nature Communications · doi:10.1038/ncomms11262 · Cited by 244 · see citing works
Mishkind, M., Vermeer, J. E. M., Darwish, E., & Munnik, T. (2009) · The Plant Journal · doi:10.1111/j.1365-313x.2009.03933.x · Cited by 234 · see citing works
Phosphoinositides : key players in cell signalling, in time and space
Payrastre, B., Missy, K., Giuriato, S., Bodin, S., Plantavid, M. M., & Gratacap, M. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00158-9 · Cited by 224 · see citing works
Shi, J., Wang, H., Hazebroek, J. P., Ertl, D., & Harp, T. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2005.02412.x · Cited by 216 · see citing works
Nuclear PtdIns(4,5)P2 assembles in a mitotically regulated particle involved in pre-mRNA splicing
Osborne, S. L., Thomas, C., Gschmeissner, S., & Schiavo, G. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.13.2501 · Cited by 214 · see citing works
Lemtiri‐Chlieh, F., MacRobbie, E. A. C., & Brearley, C. A. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140217497 · Cited by 208 · see citing works
Nagy, R., Grob, H., Weder, B., Green, P., Klein, M., Frelet‐Barrand, A., Schjoerring, J. K., Brearley, C. A., & Martinoia, E. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.030247 · Cited by 207 · see citing works
Myo-Inositol and Its Derivatives: Their Emerging Role in the Treatment of Human Diseases
Chhetri, D. R. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01172 · Cited by 189 · see citing works
Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease
Bizzarri, M., Fuso, A., Dinicola, S., Cucina, A., & Bevilacqua, A. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1206887 · Cited by 185 · see citing works
Imaging phosphatidylinositol 4‐phosphate dynamics in living plant cells
Vermeer, J. E. M., Thole, J. M., Goedhart, J., Nielsen, E., Munnik, T., & Gadella, T. W. J. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03679.x · Cited by 180 · see citing works
MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
Dovey, C. M., Diep, J., Clarke, B. P., Hale, A. T., McNamara, D. E., Guo, H., Brown, N. W., Cao, J. Y., Grace, C. R., Gough, P. J., et al. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.05.010 · Cited by 175 · see citing works
Self-citationInositol pyrophosphates: metabolism and signaling
Bennett, M., Onnebo, S. M. N., Azevedo, C., & Saiardi, A. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5446-z · Cited by 173 · see citing works
How versatile are inositol phosphate kinases?
Shears, S. B. (2004) · Biochemical Journal · doi:10.1042/bj20031428 · Cited by 173 · see citing works
Inositol pyrophosphates regulate endocytic trafficking
Saiardi, A., Sciambi, C. J., McCaffery, J. M., Wendland, B., & Snyder, S. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.212527899 · Cited by 171 · see citing works
Nunes, A. C. S., Vianna, G. R., Cúneo, F., Amaya‐Farfán, J., de Capdeville, G., Rech, E. L., & Aragão, F. J. L. (2006) · Planta · doi:10.1007/s00425-005-0201-0 · Cited by 169 · see citing works
Regulation of nuclear processes by inositol polyphosphates
York, J. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.04.014 · Cited by 168 · see citing works
Self-citationSignal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae
Pan, X., Harashima, T., & Heitman, J. (2000) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00142-9 · Cited by 165 · see citing works
Tsui, M. M. K., & York, J. D. (2009) · Advances in Enzyme Regulation · doi:10.1016/j.advenzreg.2009.12.002 · Cited by 162 · see citing works
Self-citationLithium and valproic acid: parallels and contrasts in diverse signaling contexts
Gurvich, N. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00299-1 · Cited by 162 · see citing works
Saiardi, A., Resnick, A. C., Snowman, A. M., Wendland, B., & Snyder, S. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409322102 · Cited by 161 · see citing works
Moonlighting Proteins in Yeasts
Gancedo, C., & Flores, C. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-07 · Cited by 161 · see citing works
Inositol Pyrophosphates as Mammalian Cell Signals
Chakraborty, A., Kim, S., & Snyder, S. H. (2011) · Science Signaling · doi:10.1126/scisignal.2001958 · Cited by 160 · see citing works
A Role for Nuclear Phospholipase Cβ1 in Cell Cycle Control
Faenza, I., Matteucci, A., Manzoli, L., Billi, A. M., Aluigi, M., Peruzzi, D., Vitale, M., Castorina, S., Suh, P., & Cocco, L. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004630200 · Cited by 156 · see citing works
Inositol Diphosphate Signaling Regulates Telomere Length
York, S. J., Armbruster, B. N., Greenwell, P. W., Petes, T. D., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m412070200 · Cited by 153 · see citing works
Self-citationCa2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models
Mellström, B., Savignac, M., Gómez‐Villafuertes, R., & Naranjo, J. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00041.2005 · Cited by 152 · see citing works
Signalling pathways in the pathogenesis of Cryptococcus
Kozubowski, L., Lee, S. C., & Heitman, J. (2008) · Cellular Microbiology · doi:10.1111/j.1462-5822.2008.01273.x · Cited by 150 · see citing works
Amino Acid Signaling to MTOR Mediated by Inositol Polyphosphate Multikinase
Kim, S., Kim, S. F., Maag, D., Maxwell, M. J., Resnick, A. C., Juluri, K. R., Chakraborty, A., Koldobskiy, M. A., Cha, S. H., Barrow, R., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.007 · Cited by 144 · see citing works
Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum
Barlow, C. A., Laishram, R. S., & Anderson, R. A. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.09.009 · Cited by 140 · see citing works
Frederick, J. P., Mattiske, D., Wofford, J. A., Megosh, L. C., Drake, L. Y., Chiou, S.-T., Hogan, B. L. M., & York, J. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503706102 · Cited by 139 · see citing works
Self-citationKuo, H., Chang, T., Chiang, S., Wang, W., Charng, Y., & Chiou, T. (2014) · The Plant Journal · doi:10.1111/tpj.12650 · Cited by 138 · see citing works
Molecular and Biochemical Characterization of Two Plant Inositol Polyphosphate 6-/3-/5-Kinases
Stevenson, J. M., John, A. R. O., & York, J. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209112200 · Cited by 136 · see citing works
Self-citationSeed Biofortification and Phytic Acid Reduction: A Conflict of Interest for the Plant?
Sparvoli, F., & Cominelli, E. (2015) · Plants · doi:10.3390/plants4040728 · Cited by 135 · see citing works
Auesukaree, C., Tochio, H., Shirakawa, M., Kaneko, Y., & Harashima, S. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414579200 · Cited by 132 · see citing works
Specificity Determinants in Phosphoinositide Dephosphorylation
Tsujishita, Y., Guo, S., Stolz, L. E., York, J. D., & Hurley, J. H. (2001) · Cell · doi:10.1016/s0092-8674(01)00326-9 · Cited by 132 · see citing works
Self-citationDubois, E. L., Scherens, B., Vierendeels, F., Ho, M. W. Y., Messenguy, F., & Shears, S. B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202206200 · Cited by 132 · see citing works
Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus
Strahl, T., Hama, H., DeWald, D. B., & Thorner, J. W. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200504104 · Cited by 130 · see citing works
Irvine, R. F. (2002) · Science Signaling · doi:10.1126/stke.2002.150.re13 · Cited by 128 · see citing works
Nuclear PI3K signaling in cell growth and tumorigenesis
Davis, W. J., Lehmann, P. Z., & Li, W. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00024 · Cited by 127 · see citing works
Mechanisms of Ca2+-dependent transcription
Mellström, B., & Naranjo, J. R. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00213-0 · Cited by 124 · see citing works
Extraction and analysis of soluble inositol polyphosphates from yeast
Azevedo, C., & Saiardi, A. (2006) · Nature Protocols · doi:10.1038/nprot.2006.337 · Cited by 123 · see citing works
Suzuki, M., Tanaka, K., Kuwano, M., & Yoshida, K. T. (2007) · Gene · doi:10.1016/j.gene.2007.09.006 · Cited by 119 · see citing works
Inositol Polyphosphate Multikinase Is a Nuclear PI3-Kinase with Transcriptional Regulatory Activity
Resnick, A. C., Snowman, A. M., Kang, B. N., Hurt, K. J., Snyder, S. H., & Saiardi, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506184102 · Cited by 119 · see citing works
Sei, Y., Zhao, X., Forbes, J., Szymczak, S., Li, Q., Trivedi, A., Voellinger, M., Joy, G., Feng, J., Whatley, M., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.008 · Cited by 119 · see citing works
Inositol Polyphosphates Regulate Zebrafish Left-Right Asymmetry
Sarmah, B., Latimer, A. J., Appel, B., & Wente, S. R. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.05.002 · Cited by 117 · see citing works
Self-citationBlind, R. D., Suzawa, M., & Ingraham, H. A. (2012) · Science Signaling · doi:10.1126/scisignal.2003111 · Cited by 117 · see citing works
Hunt, A. N., Clark, G. T., Attard, G. S., & Postle, A. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009878200 · Cited by 115 · see citing works
The Synthesis of Inositol Hexakisphosphate
Verbsky, J. W., Wilson, M. P., Kisseleva, M. V., Majerus, P. W., & Wente, S. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205682200 · Cited by 111 · see citing works
Self-citationSaiardi, A., Nagata, E., Luo, H. R., Sawa, A., Luo, X., Snowman, A. M., & Snyder, S. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041614598 · Cited by 110 · see citing works
Inositol phosphate synthesis and the nuclear processes they affect
Monserrate, J. P., & York, J. D. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2010.03.006 · Cited by 101 · see citing works
Self-citationBiochemical and Functional Characterization of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinases
Ives, E. B., Nichols, J. D., Wente, S. R., & York, J. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007586200 · Cited by 100 · see citing works
Self-citationInositide evolution – towards turtle domination?
Irvine, R. F. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.087387 · Cited by 100 · see citing works
Feng, Y., Wente, S. R., & Majerus, P. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.875 · Cited by 100 · see citing works
Self-citationInositol polyphosphates: a new frontier for regulating gene expression
Alcázar-Román, A. R., & Wente, S. R. (2007) · Chromosoma · doi:10.1007/s00412-007-0126-4 · Cited by 99 · see citing works
Self-citationMatrix domain modulates HIV-1 Gag's nucleic acid chaperone activity via inositol phosphate binding
Jones, C. P., Datta, S. A. K., Rein, A., Rouzina, I., & Musier-Forsyth, K. (2011) · Journal of Virology · doi:10.1128/jvi.01809-10 · Cited by 94 · see citing works
Bhati, K. K., Aggarwal, S., Sharma, S., Mantri, S. S., Singh, S. P., Bhalla, S., Kaur, J., Tiwari, S., Roy, J. K., Tuli, R., et al. (2014) · Plant Science · doi:10.1016/j.plantsci.2014.04.009 · Cited by 93 · see citing works
Nuclear phospholipase C and signaling
Cocco, L., Martelli, A. M., Gilmour, R. S., Rhee, S. G., & Manzoli, F. A. (2001) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/s1388-1981(00)00169-4 · Cited by 93 · see citing works
ITPK1 Mediates the Lipid-Independent Synthesis of Inositol Phosphates Controlled by Metabolism
Desfougères, Y., Wilson, M. S. C., Laha, D., Miller, G. J., & Saiardi, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911431116 · Cited by 93 · see citing works
Berdy, S. E., Kudla, J., Gruissem, W., & Gillaspy, G. E. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.126.2.801 · Cited by 91 · see citing works
Chromatin-Associated Genes Protect the Yeast Genome From Ty1 Insertional Mutagenesis
Nyswaner, K. M., Checkley, M. A., Yi, M., Stephens, R. M., & Garfinkel, D. J. (2008) · Genetics · doi:10.1534/genetics.107.082602 · Cited by 90 · see citing works
Anti-angiogenic activity of inositol hexaphosphate (IP6)
Vučenik, I. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh232 · Cited by 90 · see citing works
Yang, L., Tang, R., Zhu, J., Liu, H., Mueller‐Roeber, B., Xia, H., & Zhang, H. (2007) · Plant Molecular Biology · doi:10.1007/s11103-007-9267-3 · Cited by 90 · see citing works
An expanded view of inositol signaling
York, J. D., Guo, S., John, A. R. O., Spiegelberg, B. D., & Stolz, L. E. (2001) · Advances in Enzyme Regulation · doi:10.1016/s0065-2571(00)00025-x · Cited by 90 · see citing works
Self-citationDo Mammals Make All Their Own Inositol Hexakisphosphate?
Letcher, A. J., Schell, M. J., & Irvine, R. F. (2008) · Biochemical Journal · doi:10.1042/bj20081417 · Cited by 90 · see citing works
NALASKOWSKI, M. M., DESCHERMEIER, C., FANICK, W., & MAYR, G. W. (2002) · Biochemical Journal · doi:10.1042/bj20020327 · Cited by 89 · see citing works
A Molecular Basis for Inositol Polyphosphate Synthesis in Drosophila melanogaster
Seeds, A. M., Sandquist, J. C., Spana, E. P., & York, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408295200 · Cited by 89 · see citing works
Self-citationStructure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase
González, B., Schell, M. J., Letcher, A. J., Veprintsev, D. B., Irvine, R. F., & Williams, R. L. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.08.004 · Cited by 89 · see citing works
Phosphatidylinositol biosynthesis: Biochemistry and regulation
Gardocki, M. E., Jani, N. M., & Lopes, J. M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.05.006 · Cited by 89 · see citing works
Shi, Y. G., & Shi, Y. (2004) · Trends in Genetics · doi:10.1016/j.tig.2004.07.004 · Cited by 88 · see citing works
Binding of Inositol Hexakisphosphate (IP6) to Ku but Not to DNA-PKcs
Ma, Y., & Lieber, M. R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200030200 · Cited by 85 · see citing works
Xia, H., Brearley, C. A., Elge, S., Kaplan, B., Fromm, H., & Mueller‐Roeber, B. (2003) · The Plant Cell · doi:10.1105/tpc.006676 · Cited by 84 · see citing works
Inositol 1,4,5-trisphosphate 3-kinases: functions and regulations
Xia, H., & Yang, G. (2005) · Cell Research · doi:10.1038/sj.cr.7290270 · Cited by 83 · see citing works
Nuclear phosphoinositides and their impact on nuclear functions
Shah, Z. H., Jones, D. R., Sommer, L., Foulger, R., Bultsma, Y., D’Santos, C. S., & Divecha, N. (2013) · FEBS Journal · doi:10.1111/febs.12543 · Cited by 81 · see citing works
The emerging roles of inositol pyrophosphates in eukaryotic cell physiology
Thota, S. G., & Bhandari, R. (2015) · Journal of Biosciences · doi:10.1007/s12038-015-9549-x · Cited by 80 · see citing works
Regulation of immune cell development through soluble inositol-1,3,4,5-tetrakisphosphate
Sauer, K., & Cooke, M. P. (2010) · Nature reviews. Immunology · doi:10.1038/nri2745 · Cited by 80 · see citing works
The Pathway for the Production of Inositol Hexakisphosphate in Human Cells
Verbsky, J. W., Chang, S., Wilson, M. P., Mochizuki, Y., & Majerus, P. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411528200 · Cited by 80 · see citing works
Wickramasinghe, V. O., Savill, J. M., Chavali, S., Jonsdottir, A. B., Rajendra, E., Grüner, T., Laskey, R. A., Babu, M. M., & Venkitaraman, A. R. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.08.031 · Cited by 80 · see citing works
Phosphoinositide-derived messengers in endocrine signaling
Balla, T. (2006) · Journal of Endocrinology · doi:10.1677/joe.1.06595 · Cited by 80 · see citing works
- Authors
- Odom, A. R., Stahlberg, A., Wente, S. R., & York, J. D.
- Affiliations
- Departments of Pharmacology and Cancer Biology and of Biochemistry, Duke University Medical Center, DUMC 3813, Durham, NC 27710, USA.
- Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid, St. Louis, MO 63110, USA.
- Washington University in St. Louis (US)
- Duke University (US)
- Corresponding author
- York, John D.
- Venue
- Science
- Published
- 2000-03-17
- Volume
- 287
- Issue
- 5460
- Pages
- 2026-2029
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2087358641
- Cited by
- 394
- References
- 39
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 10 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 13 · 2015: 17 · 2014: 6 · 2013: 11 · 2012: 21
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- phytic acid, mRNA export, transcriptional regulation, Saccharomyces cerevisiae, gene expression regulation
- MeSH terms
- Amino Acid Sequence, Arginine, Cell Nucleus, DNA-Binding Proteins, Inositol Phosphates, Molecular Sequence Data, Type C Phospholipases, Phosphoric Monoester Hydrolases, Phosphorylation, Phytic Acid, Saccharomyces cerevisiae, Transcription Factors, Transcription, Genetic, Signal Transduction, Inositol 1,4,5-Trisphosphate, Gene Expression Regulation, Fungal, Phosphotransferases (Alcohol Group Acceptor), Minichromosome Maintenance 1 Protein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
