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Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels
Open accessAbstract
Significance: Mechanical force opens mechanosensitive ion channels in the cellular membrane to produce electrical signals that underlie sensation of touch, hearing, and other mechanical stimuli. An unanswered question is: How are mechanical forces transmitted to eukaryotic mechanosensitive channels in the membrane? We show that two mechanosensitive ion channels in eukaryotes, TRAAK (K2P4.1) and TREK1 (K2P2.1), are directly opened by mechanical force through the lipid membrane in the absence of all other cellular components. This finding extends the “force-from-lipid” paradigm established in bacterial channels to TRAAK and TREK1, eukaryotic mechanosensors.
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Cited by
Mechanically Activated Ion Channels
Ranade, S. S., Syeda, R., & Patapoutian, A. (2015) · Neuron · doi:10.1016/j.neuron.2015.08.032 · Cited by 652
Cox, C. D., Bae, C., Ziegler, L., Hartley, S., Nikolova-Krstevski, V., Rohde, P. R., Ng, C.-A., Sachs, F., Gottlieb, P. A., & Martinac, B. (2016) · Nature Communications · doi:10.1038/ncomms10366 · Cited by 528
Force-induced conformational changes in PIEZO1
Lin, Y.-C., Guo, Y. R., Miyagi, A., Levring, J., MacKinnon, R., & Scheuring, S. (2019) · Nature · doi:10.1038/s41586-019-1499-2 · Cited by 433
Self-citationTRPV4: molecular conductor of a diverse orchestra
White, J. P. M., Cibelli, M., Urban, L., Nilius, B., McGeown, J. G., & Nagy, I. (2016) · Physiological Reviews · doi:10.1152/physrev.00016.2015 · Cited by 405
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Metadata
- Authors
- Brohawn, S. G., Su, Z., & MacKinnon, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-02-18
- Volume
- 111
- Issue
- 9
- Pages
- 3614-3619
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1980802466
- Cited by
- 403
- References
- 0
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Brohawn, S. G., Su, Z., & MacKinnon, R. (2014). Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K + channels. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1320768111
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