The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain
Open accessAbstract
Significance: Establishing consciousness in the human brain requires an ensemble activity of multiple cortical and subcortical structures. Following severe brain injuries, widespread deafferentation and neuronal death alter function across the corticothalamic system and its projections to the basal ganglia. In this paper, we test a theoretical model of a mesocircuit mechanism likely to arise in all severe brain injuries. Specifically, reduction of resting glucose metabolism within the central thalamus, striatum, and frontoparietal cortices and concomitant increases in metabolism within the globus pallidus as a result of disinhibition are proposed to arise across etiologies of injury. Here we verify this prediction and demonstrate a reversal of metabolic profile of central thalamus and globus pallidus that characterizes and indexes the patients’ behavioral level.
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“Current atlas-based approaches cannot precisely describe subcortical changes in severely deformed brains [17].”
From The Minimal Energetic Requirement of Sustained Awareness after Brain Injury (2016) · cites this paper as [17]
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A default mode of brain function
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General Anesthesia, Sleep, and Coma
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Self-citationBrain function in coma, vegetative state, and related disorders
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Self-citationStratification of unresponsive patients by an independently validated index of brain complexity
Casarotto, S., Comanducci, A., Rosanova, M., Sarasso, S., Fecchio, M., Napolitani, M., Pigorini, A., G. Casali, A., Trimarchi, P. D., Boly, M., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24779 · Cited by 487
Self-citationTherapeutic interventions in patients with prolonged disorders of consciousness
Thibaut, A., Schiff, N. D., Giacino, J. T., Laureys, S., & Gosseries, O. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30031-6 · Cited by 433
Self-citationStructural and functional connectivity of the precuneus and thalamus to the default mode network
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Akeju, O., Loggia, M. L., Catana, C., Pavone, K. J., Vazquez, R., Rhee, J., Contreras Ramirez, V., Chonde, D. B., Izquierdo-Garcia, D., Arabasz, G., et al. (2014) · eLife · doi:10.7554/elife.04499 · Cited by 168
Metadata
- Authors
- Fridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D.
- Affiliations
- Weill Cornell Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Columbia University Irving Medical Center (US)
- University of Liège (BE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-14
- Volume
- 111
- Issue
- 17
- Pages
- 6473-6478
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4035959
- OpenAlex
- W1993492847
- Cited by
- 147
- References
- 55
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 19 · 2023: 15 · 2022: 12 · 2021: 11 · 2020: 4 · 2019: 11 · 2018: 22 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 5
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health (HD51912)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD051912, 1R01-HD51912)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- disorders of consciousness, severe brain injury, central thalamus, globus pallidus, striatum, deafferentation, frontoparietal network, regional cerebral glucose metabolism, command following, consciousness recovery
- MeSH terms
- Brain Injuries, Demography, Female, Glucose, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Rest, Case-Control Studies, Cerebrum
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