The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Regional cerebral metabolic patterns demonstrate the role of anterior forebrain mesocircuit dysfunction in the severely injured brain
Open accessAbstract
Significance: Establishing consciousness in the human brain requires an ensemble activity of multiple cortical and subcortical structures. Following severe brain injuries, widespread deafferentation and neuronal death alter function across the corticothalamic system and its projections to the basal ganglia. In this paper, we test a theoretical model of a mesocircuit mechanism likely to arise in all severe brain injuries. Specifically, reduction of resting glucose metabolism within the central thalamus, striatum, and frontoparietal cortices and concomitant increases in metabolism within the globus pallidus as a result of disinhibition are proposed to arise across etiologies of injury. Here we verify this prediction and demonstrate a reversal of metabolic profile of central thalamus and globus pallidus that characterizes and indexes the patients’ behavioral level.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Current atlas-based approaches cannot precisely describe subcortical changes in severely deformed brains [17].”
From The Minimal Energetic Requirement of Sustained Awareness after Brain Injury (2016) · cites this paper as [17]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Tzourio-Mazoyer, N., Landeau, B., Papathanassiou, D., Crivello, F., Etard, O., Delcroix, N., Mazoyer, B., & Joliot, M. (2002) · NeuroImage · doi:10.1006/nimg.2001.0978 · Cited by 16,319
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371
Giacino, J. T., Kalmar, K., & Whyte, J. (2004) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2004.02.033 · Cited by 1,884
Modulation of Striatal Projection Systems by Dopamine
Gerfen, C. R., & Surmeier, D. J. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113641 · Cited by 1,700
General Anesthesia, Sleep, and Coma
Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,413
Self-citationDopamine (3-hydroxytyramine) and brain function.
Hornykiewicz, O. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07154-6 · Cited by 1,389
Behavioural improvements with thalamic stimulation after severe traumatic brain injury
Schiff, N. D., Giacino, J. T., Kalmar, K., Victor, J. D., Baker, K., Gerber, M., Fritz, B., Eisenberg, B., O’Connor, J., Kobylarz, E. J., et al. (2007) · Nature · doi:10.1038/nature06041 · Cited by 1,051
Self-citationBrain function in coma, vegetative state, and related disorders
Laureys, S., Owen, A. M., & Schiff, N. D. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00852-x · Cited by 1,033
Self-citationOrbitofrontal Cortex and Its Contribution to Decision-Making
Wallis, J. D. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094334 · Cited by 945
Cited by
Sorted by citations
Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies
Edlow, B. L., Claassen, J., Schiff, N. D., & Greer, D. M. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-00428-x · Cited by 773
Self-citationStratification of unresponsive patients by an independently validated index of brain complexity
Casarotto, S., Comanducci, A., Rosanova, M., Sarasso, S., Fecchio, M., Napolitani, M., Pigorini, A., G. Casali, A., Trimarchi, P. D., Boly, M., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24779 · Cited by 487
Self-citationTherapeutic interventions in patients with prolonged disorders of consciousness
Thibaut, A., Schiff, N. D., Giacino, J. T., Laureys, S., & Gosseries, O. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(19)30031-6 · Cited by 433
Self-citationStructural and functional connectivity of the precuneus and thalamus to the default mode network
Cunningham, S. I., Tomasi, D. G., & Volkow, N. D. (2016) · Human Brain Mapping · doi:10.1002/hbm.23429 · Cited by 218
Akeju, O., Loggia, M. L., Catana, C., Pavone, K. J., Vazquez, R., Rhee, J., Contreras Ramirez, V., Chonde, D. B., Izquierdo-Garcia, D., Arabasz, G., et al. (2014) · eLife · doi:10.7554/elife.04499 · Cited by 168
Rosanova, M., Fecchio, M., Casarotto, S., Sarasso, S., Casali, A. G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-06871-1 · Cited by 167
Self-citationForgacs, P. B., Conte, M. M., Fridman, E. A., Voss, H. U., Victor, J. D., & Schiff, N. D. (2014) · Annals of Neurology · doi:10.1002/ana.24283 · Cited by 165
Self-citationFrequency-selective control of cortical and subcortical networks by central thalamus
Liu, J., Lee, H. J., Weitz, A. J., Fang, Z., Lin, P., Choy, M., Fisher, R. S., Pinskiy, V., Tolpygo, A. S., Mitra, P. P., et al. (2015) · eLife · doi:10.7554/elife.09215 · Cited by 161
Self-citationCharacterization of EEG signals revealing covert cognition in the injured brain
Curley, W. H., Forgacs, P. B., Voss, H. U., Conte, M. M., & Schiff, N. D. (2018) · Brain · doi:10.1093/brain/awy070 · Cited by 144
Self-citationThe Minimal Energetic Requirement of Sustained Awareness after Brain Injury
Stender, J., Mortensen, K. N., Thibaut, A., Darkner, S., Laureys, S., Gjedde, A., & Kupers, R. (2016) · Current Biology · doi:10.1016/j.cub.2016.04.024 · Cited by 131
Self-citationEdlow, B. L., Sanz, L. R. D., Polizzotto, L., Pouratian, N., Rolston, J. D., Snider, S. B., Thibaut, A., Stevens, R. D., Gosseries, O., members, T. C. C. C. A. I. C., et al. (2021) · Neurocritical Care · doi:10.1007/s12028-021-01227-y · Cited by 132
Disconnecting Consciousness: Is There a Common Anesthetic End Point?
Hudetz, A. G., & Mashour, G. A. (2016) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000001353 · Cited by 121
Forgacs, P. B., Frey, H., Velazquez, A. G., Thompson, S., Brodie, D., Moitra, V. K., Rabani, L. E., Park, S., Agarwal, S., Falo, M. C., et al. (2017) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.385 · Cited by 110
Self-citationNeuroprotective role of lactate in rat neonatal hypoxia-ischemia
Roumes, H., Dumont, U., Sanchez, S., Mazuel, L., Blanc, J., Raffard, G., Chateil, J., Pellerin, L., & Bouzier‐Sore, A. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x20908355 · Cited by 114
Thibaut, A., Perri, C. D., Chatelle, C., Bruno, M., Bahri, M. A., Wannez, S., Piarulli, A., Bernard, C., Martial, C., Heine, L., et al. (2015) · Brain stimulation · doi:10.1016/j.brs.2015.07.024 · Cited by 102
Self-citationMapping the subcortical connectivity of the human default mode network
Li, J., Curley, W. H., Guérin, B., Dougherty, D. D., Dalca, A. V., Fischl, B. R., Horn, A., & Edlow, B. L. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118758 · Cited by 98
Intranasal insulin treatment of an experimental model of moderate traumatic brain injury
Brabazon, F., Wilson, C. M., Jaiswal, S., Reed, J., Frey, W. H., & Byrnes, K. R. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16685106 · Cited by 88
Disorders of consciousness after severe brain injury: therapeutic options
Caroline Schnakers, A., & Monti, M. M. (2017) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000495 · Cited by 87
Lant, N. D., González-Lara, L. E., Owen, A. M., & Fernández‐Espejo, D. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.11.004 · Cited by 86
Gregorio, F. D., Porta, F. L., Petrone, V., Battaglia, S., Orlandi, S., Ippolito, G., Romei, V., Piperno, R., & Lullini, G. (2022) · Biomedicines · doi:10.3390/biomedicines10081897 · Cited by 85
Weng, L., Xie, Q., Zhao, L., Zhang, R., Ma, Q., Wang, J., Jiang, W., Yan-bin, H., Chen, Y., Li, C., et al. (2017) · Cortex · doi:10.1016/j.cortex.2017.02.011 · Cited by 79
Changes in cerebral metabolism in patients with a minimally conscious state responding to zolpidem
Chatelle, C., Thibaut, A., Gosseries, O., Bruno, M., Athena Demertzi, A., Bernard, C., Hustinx, R., Tshibanda, L., Bahri, M. A., & Laureys, S. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00917 · Cited by 74
Self-citationBriand, M., Gosseries, O., Staumont, B., Laureys, S., & Thibaut, A. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00933 · Cited by 79
Self-citationPanda, R., Thibaut, A., López‐González, A., Escrichs, A., Bahri, M. A., Hillebrand, A., Deco, G., Laureys, S., Gosseries, O., Annen, J., et al. (2022) · eLife · doi:10.7554/elife.77462 · Cited by 69
Self-citationAnnen, J., Heine, L., Ziegler, E., Frasso, G., Bahri, M. A., Perri, C. D., Stender, J., Martial, C., Wannez, S., D’Ostilio, K., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23269 · Cited by 60
Self-citationKuceyeski, A. F., Jamison, K. W., Owen, J. P., Raj, A., & Mukherjee, P. (2019) · Human Brain Mapping · doi:10.1002/hbm.24713 · Cited by 49
Abnormal dynamic properties of functional connectivity in disorders of consciousness
Cao, B., Chen, Y., Yu, R., Chen, L., Chen, P., Weng, Y., Chen, Q., Song, J., Xie, Q., & Huang, R. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.102071 · Cited by 55
Neuromodulation of the conscious state following severe brain injuries
Fridman, E. A., & Schiff, N. D. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.008 · Cited by 53
Self-citationMesocircuit mechanisms in the diagnosis and treatment of disorders of consciousness
Schiff, N. D. (2022) · La Presse Médicale · doi:10.1016/j.lpm.2022.104161 · Cited by 56
Self-citationSchiff, N. D. (2015) · Springer eBooks · doi:10.1007/978-3-319-21425-2_15 · Cited by 51
Self-citationThengone, D. J., Voss, H. U., Fridman, E. A., & Schiff, N. D. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf6113 · Cited by 51
Self-citationExecutive attention deficits after traumatic brain injury reflect impaired recruitment of resources
Shah, S. A., Goldin, Y., Conte, M. M., Goldfine, A. M., Mohamadpour, M., Fidali, B. C., Cicerone, K. D., & Schiff, N. D. (2017) · NeuroImage Clinical · doi:10.1016/j.nicl.2017.01.010 · Cited by 57
Self-citationSchiff, N. D. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1547-0 · Cited by 49
Self-citationSoddu, A., Gómez, F., Heine, L., Perri, C. D., Bahri, M. A., Voss, H. U., Bruno, M., Vanhaudenhuyse, A., Phillips, C. L. M., Athena Demertzi, A., et al. (2015) · Brain and Behavior · doi:10.1002/brb3.424 · Cited by 54
Self-citationRedinbaugh, M. J., Afrasiabi, M., Phillips, J. M., Kambi, N. A., Mohanta, S., Raz, A., & Saalmann, Y. B. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1010294 · Cited by 45
BCI in patients with disorders of consciousness: Clinical perspectives
Luauté, J., Morlet, D., & Mattout, J. (2015) · Annals of Physical and Rehabilitation Medicine · doi:10.1016/j.rehab.2014.09.015 · Cited by 47
Presynaptic dopamine deficit in minimally conscious state patients following traumatic brain injury
Fridman, E. A., Osborne, J. R., Mozley, P. D., Victor, J. D., & Schiff, N. D. (2019) · Brain · doi:10.1093/brain/awz118 · Cited by 46
Self-citationElectrophysiological correlates of thalamocortical function in acute severe traumatic brain injury
Curley, W. H., Bodien, Y. G., Zhou, D. W., Conte, M. M., Foulkes, A. S., Giacino, J. T., Victor, J. D., Schiff, N. D., & Edlow, B. L. (2022) · Cortex · doi:10.1016/j.cortex.2022.04.007 · Cited by 41
Self-citationCrone, J., Bio, B. J., Vespa, P., Lutkenhoff, E., & Monti, M. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24115 · Cited by 38
Coulborn, S., Taylor, C., Naçi, L., Owen, A. M., & Fernández‐Espejo, D. (2021) · Brain Sciences · doi:10.3390/brainsci11060749 · Cited by 32
Chen, Y., & Zhang, J. (2021) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2021.648860 · Cited by 39
Restoring consciousness with pharmacologic therapy: Mechanisms, targets, and future directions
Barra, M. E., Solt, K., Yu, X., & Edlow, B. L. (2024) · Neurotherapeutics · doi:10.1016/j.neurot.2024.e00374 · Cited by 29
Kang, Y., Jamison, K. W., Jaywant, A., Dams-O’Connor, K., Kim, N., Karakatsanis, N. A., Butler, T., Schiff, N. D., Kuceyeski, A. F., & Shah, S. A. (2022) · Brain Communications · doi:10.1093/braincomms/fcac159 · Cited by 25
Self-citationSanz, L. R. D., Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., Farber, N. M., ZAFONTE, R. D., Schiff, N. D., Laureys, S., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00248 · Cited by 25
Self-citationGottshall, J. L., Adams, Z. M., Forgacs, P. B., & Schiff, N. D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00020 · Cited by 23
Self-citationComanducci, A., Casarotto, S., Rosanova, M., Derchi, C., Viganò, A., Pirastru, A., Blasi, V., Cazzoli, M., Navarro, J., Edlow, B. L., et al. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.15994 · Cited by 23
Cerebral Electrometabolic Coupling in Disordered and Normal States of Consciousness
Annen, J., Frasso, G., van der Lande, G., Bonin, E., Vitello, M. M., Panda, R., Sala, A., Cavaliere, C., Raimondo, F., Bahri, M. A., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2023.112854 · Cited by 22
Self-citationFocal Electroencephalographic Changes Index Post-Traumatic Confusion and Outcome
Shah, S. A., Mohamadpour, M., Askin, G., Nakase‐Richardson, R., Stokić, D. S., Sherer, M., Yablon, S. A., & Schiff, N. D. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4911 · Cited by 23
Self-citationBrain state identification and neuromodulation to promote recovery of consciousness
van der Lande, G., Casas-Torremocha, D., Manasanch, A., Porta, L. D., Gosseries, O., Alnagger, N., Barra, A., Mejías, J. F., Panda, R., Riefolo, F., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae362 · Cited by 26
Self-citationThalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness
Cacciatore, M., Magnani, F. G., Barbadoro, F., Ippoliti, C., Stanziano, M., Clementi, L., Nigri, A., Nanetti, L., Marino, S., Porta, F. L., et al. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1509668 · Cited by 26
Vitello, M. M., Briand, M., Ledoux, D., Annen, J., Tahry, R. E., Laureys, S., Martin, D., Gosseries, O., & Thibaut, A. (2022) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2022.100360 · Cited by 24
Self-citationInjury patterns associated with cognitive motor dissociation
Franzova, E., Shen, Q., Doyle, K. W., Chen, J. M., Egbebike, J. A., Vrosgou, A., Carmona, J. C., Grobois, L., Heinonen, G., Velazquez, A. G., et al. (2023) · Brain · doi:10.1093/brain/awad197 · Cited by 23
Berlingeri, M., Ravasio, A., Cranna, S., Basilico, S., Sberna, M., Bottini, G., & Paulesu, E. (2015) · Consciousness and Cognition · doi:10.1016/j.concog.2015.08.010 · Cited by 23
Altered States of Consciousness after Brain Injury
Stender, J., Laureys, S., & Gosseries, O. (2017) · Wiley eBooks · doi:10.1002/9781119132363.ch47 · Cited by 23
Self-citationBarra, A., Monti, M. M., & Thibaut, A. (2022) · Seminars in Neurology · doi:10.1055/s-0042-1755562 · Cited by 23
McGuire, J. L., DePasquale, E. A. K., Watanabe, M., Anwar, F. N., Ngwenya, L. B., Atluri, G., Romick‐Rosendale, L. E., McCullumsmith, R. E., & Evanson, N. K. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1276-5 · Cited by 22
Forgacs, P. B., Allen, B. B., Wu, X. Z., Gerber, L. M., Boddu, S. R., Fakhar, M., Stieg, P. E., Schiff, N. D., & Mangat, H. S. (2021) · Neurocritical Care · doi:10.1007/s12028-021-01354-6 · Cited by 21
Self-citationHe, J., Zhang, H., Dang, Y., Zhuang, Y., Ge, Q., Yang, Y., Xu, L., Xia, X., Laureys, S., Yu, S. P., et al. (2023) · Brain stimulation · doi:10.1016/j.brs.2023.09.021 · Cited by 21
Self-citationNovel approaches to prediction in severe brain injury
Fidali, B. C., Stevens, R. D., & Claassen, J. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000875 · Cited by 20
Contributions of Basal Ganglia Circuits to Perception, Attention, and Consciousness
Redinbaugh, M. J., & Saalmann, Y. B. (2024) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_02177 · Cited by 20
Abnormal Effective Connectivity of the Anterior Forebrain Regions in Disorders of Consciousness
Chen, P., Xie, Q., Wu, X., Huang, H., Lv, W., Chen, L., Guo, Y., Zhang, S., Hu, H., Wang, Y., et al. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0250-6 · Cited by 19
The role of plasticity in the recovery of consciousness
Bagnato, S. (2022) · Handbook of clinical neurology · doi:10.1016/b978-0-12-819410-2.00020-5 · Cited by 17
Naccache, L., Luauté, J., Silva, S., Sitt, J. D., & Rohaut, B. (2021) · Revue Neurologique · doi:10.1016/j.neurol.2021.12.004 · Cited by 18
Dagnino, P. C., Escrichs, A., López‐González, A., Gosseries, O., Annen, J., Perl, Y. S., Kringelbach, M. L., Laureys, S., & Deco, G. (2024) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011350 · Cited by 18
Self-citationEmerging Treatments for Disorders of Consciousness in Paediatric Age
Irzan, H., Pozzi, M., Chikhladze, N., Cebanu, S., Tadevosyan, A. E., Cornelia, C., Tsiskaridze, A., Melbourne, A., Strazzer, S., Marc Modat, A., et al. (2022) · Brain Sciences · doi:10.3390/brainsci12020198 · Cited by 18
Traumatic brain injury and disorders of consciousness
Johnson-Black, P. H., Carlson, J. M., & Vespa, P. M. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-13408-1.00014-2 · Cited by 18
Propofol Anesthesia Alters Spatial and Topologic Organization of Rat Brain Metabolism
Chen, Y., Bao, W., Liang, X., & Zhang, J. (2019) · Anesthesiology · doi:10.1097/aln.0000000000002876 · Cited by 15
How Brain Arousal Mechanisms Work
Pfaff, D. W. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108377485 · Cited by 22
Fridman, E. A., & Schiff, N. D. (2021) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0000000000000729 · Cited by 16
Self-citationEnciso-Olivera, C. O., Ordóñez-Rubiano, E. G., Libreros, R. C., Rivera, D., Zárate-Ardila, C., Rudas, J., Pulido, C., Gómez, F. A., Martínez, D., Guerrero, N., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-98506-7 · Cited by 14
He, Z., Lu, R., Guan, Y., Wu, Y., Ge, J., Liu, G., Chen, Y., Xie, H., Wu, J., & Jia, J. (2022) · Brain Sciences · doi:10.3390/brainsci12070892 · Cited by 13
Zhuang, Y., Zhai, W., Li, Q., Jiao, H., Ge, Q., Rong, P., & He, J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1165145 · Cited by 12
Non-pharmacologic interventions in disorders of consciousness
Vitello, M. M., Laureys, S., Thibaut, A., & Gosseries, O. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-13408-1.00007-5 · Cited by 13
Self-citationWan, C., Zhang, W., Nie, Y., Qian, Y., Wang, J., Xu, H., Li, Z., Su, B., Zhang, Y., & Li, Y. (2025) · PM&R · doi:10.1002/pmrj.13324 · Cited by 11
Curley, W. H., Comanducci, A., & Fecchio, M. (2022) · Seminars in Neurology · doi:10.1055/s-0042-1755220 · Cited by 11
Isolation Syndrome after Cardiac Arrest and Therapeutic Hypothermia
Forgacs, P. B., Fridman, E. A., Goldfine, A. M., & Schiff, N. D. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00259 · Cited by 11
Self-citationWu, B., Yang, Y., Zhou, S., Wang, W., Wang, Z., Hu, G., He, J., & Wu, X. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00110 · Cited by 11
Behavioral scales variability in patients with prolonged disorders of consciousness
Cortese, M. D., Vatrano, M., Arcuri, F., Raso, M. G., Tonin, P., Calabrò, R. S., & Riganello, F. (2023) · Neurological Sciences · doi:10.1007/s10072-023-06812-x · Cited by 11
Lippert, J., & Guggisberg, A. G. (2023) · Clinical and Translational Neuroscience · doi:10.3390/ctn7030021 · Cited by 11
Neuroimaging biomarkers for the diagnosis and prognosis of patients with disorders of consciousness
Wang, J., Lai, Q., Han, J., Qin, P., & Wu, H. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149133 · Cited by 10
Naro, A., Chillura, A., Portaro, S., Bramanti, A., Luca, R. D., Bramanti, P., & Calabrò, R. S. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00047 · Cited by 9
Cao, B., Guo, Y. Q., Guo, Y., Xie, Q., Chen, L., Huang, H., Yu, R., & Huang, R. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102797 · Cited by 9
Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia
Wang, T., Wang, X.-H., Jiang, W., Zhang, S., Nie, B., Zheng, Y. Z., Yan, F., & Lei, J. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.330616 · Cited by 8
Zheng, Z. S., & Monti, M. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/688283 · Cited by 11
Explaining recovery from coma with multimodal neuroimaging
Pozeg, P., Jöhr, J., Prior, J. O., Diserens, K., & Dunet, V. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12591-y · Cited by 7
Bader, F., Kochen, W. R., Kraus, M. F., & Wiener, M. (2019) · Cortex · doi:10.1016/j.cortex.2019.04.019 · Cited by 9
How Brain Arousal Mechanisms Work: Paths Toward Consciousness
Pfaff, D. W. (2018) · Cited by 9
Koninck, B. P. D., Brazeau, D., Apinis-Deshaies, A., Briand, M., Maschke, C., Williams, V., Arbour, C., Williamson, D. R., Duclos, C., Bernard, F., et al. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-078281 · Cited by 5
Yang, Y., Cao, T.-Q., He, S., Wang, L., He, Q., Fan, L., Huang, Y., Zhang, H., Wang, Y., Dang, Y., et al. (2024) · Military Medical Research · doi:10.1186/s40779-024-00585-w · Cited by 7
Yan, J., Zha, F., Zhou, J., Zhou, J., Zhao, J., Zhang, Q., Long, J., Hou, D., Song, Z., & Wang, Y. (2024) · Neurorehabilitation · doi:10.3233/nre-230282 · Cited by 5
Thibaut, A., & Schiff, N. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-55964-3_12 · Cited by 5
Self-citationZheng, R., Xu, C.-X., Zhou, L.-Y., & Feng, D. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103361 · Cited by 5
Gammel, T., Alkadaa, L. N., Saadon, J. R., Saluja, S., Servider, J., Cleri, N. A., Egnor, M. R., Davis, R. P., Huang, C., Saalmann, Y. B., et al. (2023) · Neurosurgery Open · doi:10.1227/neuprac.0000000000000031 · Cited by 5
An Unpredictable Brain Is a Conscious, Responsive Brain
Mofakham, S., Robertson, J., Lubin, N., Cleri, N. A., & Mikell, C. B. (2024) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_02154 · Cited by 4
Adversarial AI reveals mechanisms and treatments for disorders of consciousness
Toker, D., Zheng, Z. S., Thum, J. A., Guang, J., Annen, J., Miyamoto, H., Yamakawa, K., Vespa, P. M., Laureys, S., Caroline Schnakers, A., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02220-4 · Cited by 4
Self-citationEmerging Treatment for Patients with Disorders of Consciousness: The Field of Neuromodulation
Hopkins, A., Vitello, M. M., Thibaut, A., & Monti, M. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-50563-8_8 · Cited by 4
Individual trajectories for recovery of neocortical activity in disorders of consciousness
Tewarie, P. K. B., Abeysuriya, R., Panda, R., Nùñez, P., Vitello, M. M., van der Lande, G., Gosseries, O., Thibaut, A., Laureys, S., Deco, G., et al. (2025) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1013659 · Cited by 4
Self-citationFecchio, M., Rosanova, M., Casarotto, S., Sarasso, S., Casali, A. G., Pigorini, A., Comanducci, A., Seregni, F., Devalle, G., Citerio, G., et al. (2019) · Brain stimulation · doi:10.1016/j.brs.2018.12.401 · Cited by 4
Self-citationRedinbaugh, M. J., Afrasiabi, M., Phillips, J. M., Kambi, N. A., Mohanta, S., & Saalmann, Y. B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.27.453855 · Cited by 4
Multimodal PET/MR imaging of prolonged disorders of consciousness: a pilot feasibility study
Sun, N., Liu, Y., Lin, H., Xiong, J., He, Y., Yang, H., Su, M.-G., & He, J. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1761097 · Cited by 3
Metadata
- Authors
- Fridman, E. A., Beattie, B. J., Broft, A., Laureys, S., & Schiff, N. D.
- Affiliations
- Weill Cornell Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Columbia University Irving Medical Center (US)
- University of Liège (BE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-14
- Volume
- 111
- Issue
- 17
- Pages
- 6473-6478
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4035959
- OpenAlex
- W1993492847
- Cited by
- 147
- References
- 55
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 19 · 2023: 15 · 2022: 12 · 2021: 11 · 2020: 4 · 2019: 11 · 2018: 22 · 2017: 10 · 2016: 10 · 2015: 7 · 2014: 5
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health (HD51912)
- National Institute of Child Health and Human Development
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD051912, 1R01-HD51912)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- disorders of consciousness, severe brain injury, central thalamus, globus pallidus, striatum, deafferentation, frontoparietal network, regional cerebral glucose metabolism, command following, consciousness recovery
- MeSH terms
- Brain Injuries, Demography, Female, Glucose, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Rest, Case-Control Studies, Cerebrum
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review