Brain function in coma, vegetative state, and related disorders
Open accessAbstract
We review the nosological criteria and functional neuroanatomical basis for brain death, coma, vegetative state, minimally conscious state, and the locked-in state. Functional neuroimaging is providing new insights into cerebral activity in patients with severe brain damage. Measurements of cerebral metabolism and brain activations in response to sensory stimuli with PET, fMRI, and electrophysiological methods can provide information on the presence, degree, and location of any residual brain function. However, use of these techniques in people with severe brain damage is methodologically complex and needs careful quantitative analysis and interpretation. In addition, ethical frameworks to guide research in these patients must be further developed. At present, clinical examinations identify nosological distinctions needed for accurate diagnosis and prognosis. Neuroimaging techniques remain important tools for clinical research that will extend our understanding of the underlying mechanisms of these disorders.
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FDG-PET may contribute to the clinical diagnosis of disorders of consciousness.
“Likewise, FDG-PET may contribute to the clinical diagnosis of disorders of consciousness (DOCs) [4, 5].”
From The Minimal Energetic Requirement of Sustained Awareness after Brain Injury (2016) · cites this paper as [5]
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Cites
Searching for a baseline: Functional imaging and the resting human brain
Gusnard, D. A., & Raichle, M. E. (2001) · Nature Reviews Neuroscience · doi:10.1038/35094500 · Cited by 3,371 · see citing works
Towards a cognitive neuroscience of consciousness: basic evidence and a workspace framework
Dehaene, S. (2001) · Cognition · doi:10.1016/s0010-0277(00)00123-2 · Cited by 2,498 · see citing works
The minimally conscious state: Definition and diagnostic criteria
Giacino, J. T., Ashwal, S., Childs, N., Cranford, R., Jennett, B., Katz, D. I., Kelly, J. P., Rosenberg, J. H., Whyte, J., Zafonte, R. D., et al. (2002) · Neurology · doi:10.1212/wnl.58.3.349 · Cited by 2,422 · see citing works
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802 · see citing works
Frackowiak, R. S. J. (1997) · Cited by 1,713 · see citing works
Medical Aspects of the Persistent Vegetative State
The Multi-Society Task Force on PVS (1994) · New England Journal of Medicine · doi:10.1056/nejm199405263302107 · Cited by 1,541 · see citing works
Vogt, B. A., Finch, D. M., & Olson, C. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.6.435-a · Cited by 1,315 · see citing works
Neurogenesis in the Neocortex of Adult Primates
Gould, E., Reeves, A. J., Graziano, M. S. A., & Gross, C. G. (1999) · Science · doi:10.1126/science.286.5439.548 · Cited by 1,262 · see citing works
Positron emission tomography provides molecular imaging of biological processes
Phelps, M. E. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.16.9226 · Cited by 1,231 · see citing works
PERSISTENT VEGETATIVE STATE AFTER BRAIN DAMAGE
Jennett, B., & Plum, F. (1972) · The Lancet · doi:10.1016/s0140-6736(72)90242-5 · Cited by 1,230 · see citing works
Functional neuroanatomy of human rapid-eye-movement sleep and dreaming
Maquet, P., Péters, J.-M., Aerts, J., Delfiore, G., Degueldre, C., Luxen, A., & Franck, G. (1996) · Nature · doi:10.1038/383163a0 · Cited by 1,168 · see citing works
The Diagnosis of Stupor and Coma.
Plum, F., & Posner, J. B. (1967) · Annals of Internal Medicine · doi:10.7326/0003-4819-66-1-244 · Cited by 1,156 · see citing works
Spatial Normalization of Brain Images with Focal Lesions Using Cost Function Masking
Brett, M., Leff, A. P., Rorden, C., & Ashburner, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0845 · Cited by 931 · see citing works
Yearbook of Intensive Care and Emergency Medicine 2002
(2002) · Springer eBooks · doi:10.1007/978-3-642-56011-8 · Cited by 876 · see citing works
Misdiagnosis of the vegetative state: retrospective study in a rehabilitation unit: Table 1
Andrews, K., Murphy, L., Munday, R., & Littlewood, C. (1996) · BMJ · doi:10.1136/bmj.313.7048.13 · Cited by 818 · see citing works
Wijdicks, E. F. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200104193441606 · Cited by 670 · see citing works
Bergsneider, M., Hovda, D. A., Shalmon, E., Kelly, D. F., Vespa, P. M., Martin, N. A., Phelps, M. E., McArthur, D. L., Caron, M., Kraus, J. F., et al. (1997) · Journal of neurosurgery · doi:10.3171/jns.1997.86.2.0241 · Cited by 639 · see citing works
Parietal cortex and representation of the mental Self
Lou, H. C., Luber, B., Crupain, M., Keenan, J. P., Nowak, M., Kjaer, T. W., Sackeim, H. A., & Lisanby, S. H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400049101 · Cited by 631 · see citing works
Remembering the past: two facets of episodic memory explored with positron emission tomography
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.11.1576 · Cited by 593 · see citing works
Accuracy of diagnosis of persistent vegetative state
Childs, N. L., Mercer, W. N., & Childs, H. W. (1993) · Neurology · doi:10.1212/wnl.43.8.1465 · Cited by 540 · see citing works
Functional Neuroanatomy of Human Slow Wave Sleep
Maquet, P., Degueldre, C., Delfiore, G., Aerts, J. J., Peters, J., Luxen, A., & Franck, G. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02807.1997 · Cited by 512 · see citing works
Practice parameters for determining brain death in adults
(1995) · Neurology · doi:10.1212/wnl.45.5.1012 · Cited by 489 · see citing works
Fiset, P., Paus, T., Daloze, T., Plourde, G., Meuret, P., Bonhomme, V., Hajj-Ali, N., Backman, S. B., & Evans, A. C. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-13-05506.1999 · Cited by 475 · see citing works
Cerebral mechanisms of hypnotic induction and suggestion
Rainville, P., Hofbauer, R. K., Paus, T., Duncan, G. H., Bushnell, M. C., & Price, D. D. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563175 · Cited by 468 · see citing works
Cortical processing of noxious somatosensory stimuli in the persistent vegetative state
Laureys, S., Faymonville, M. E., Peigneux, P., Damas, P., Lambermont, B., Del Fiore, G., Degueldre, C., Aerts, J., Luxen, A., Franck, G., et al. (2002) · NeuroImage · doi:10.1006/nimg.2002.1236 · Cited by 432 · see citing works
Self-citationKaisti, K. K., Långsjö, J., Aalto, S., Oikonen, V., Sipilä, H. T., Teräs, M., Hinkka‐Yli‐Salomäki, S., Metsähonkala, L., & Scheinin, H. (2003) · Anesthesiology · doi:10.1097/00000542-200309000-00015 · Cited by 425 · see citing works
Guidelines for the Determination of Death
(1981) · JAMA · doi:10.1001/jama.1981.03320190042025 · Cited by 413 · see citing works
Brain, conscious experience and the observing self
Baars, B. J., Ramsøy, T. Z., & Laureys, S. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.015 · Cited by 404 · see citing works
Self-citationRestoration of thalamocortical connectivity after recovery from persistent vegetative state
Laureys, S., Faymonville, M., Luxen, A., Lamy, M., Franck, G., & Maquet, P. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02271-6 · Cited by 398 · see citing works
Self-citationZeman, A. Z. (2001) · Brain · doi:10.1093/brain/124.7.1263 · Cited by 394 · see citing works
Impaired Effective Cortical Connectivity in Vegetative State: Preliminary Investigation Using PET
Laureys, S., Goldman, S., Phillips, C. L. M., Bogaert, P. V., Aerts, J. J., Luxen, A., Franck, G., & Maquet, P. (1999) · NeuroImage · doi:10.1006/nimg.1998.0414 · Cited by 382 · see citing works
Self-citationBoly, M., Faymonville, M.-E., Peigneux, P., Lambermont, B., Damas, P., Del Fiore, G., Degueldre, C., Franck, G., Luxen, A., Lamy, M., et al. (2004) · Archives of Neurology · doi:10.1001/archneur.61.2.233 · Cited by 358 · see citing works
Self-citationCerebral Metabolism during Propofol Anesthesia in Humans Studied with Positron Emission Tomography
Alkire, M. T., Haier, R. J., Barker, S. J., Shah, N. K., Wu, J. C., & Kao, J. Y. (1995) · Anesthesiology · doi:10.1097/00000542-199502000-00010 · Cited by 350 · see citing works
Auditory processing in the vegetative state
Laureys, S. (2000) · Brain · doi:10.1093/brain/123.8.1589 · Cited by 311 · see citing works
Self-citationResidual cerebral activity and behavioural fragments can remain in the persistently vegetative brain
Schiff, N. D., Ribary, U., Moreno, D. R., Beattie, B., Kronberg, E., Blasberg, R., Giacino, J., McCagg, C., Fins, J. J., Llinás, R., et al. (2002) · Brain · doi:10.1093/brain/awf131 · Cited by 306 · see citing works
Self-citationMotion Correction Algorithms May Create Spurious Brain Activations in the Absence of Subject Motion
Freire, L., & Mangin, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0869 · Cited by 305 · see citing works
Brain activation in the processing of Chinese characters and words: A functional MRI study
Tan, L., Spinks, J. A., Gao, J., Liu, H., Perfetti, C. A., Xiong, J., Stofer, K. A., Pu, Y., Liu, Y., & Fox, P. T. (2000) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(200005)10:1 · Cited by 304 · see citing works
Medicine, A. C. O. R. (1995) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/s0003-9993(95)80031-x · Cited by 283 · see citing works
Regional cerebral glucose metabolic rate in human sleep assessed by positron emission tomography
Buchsbaum, M. S., Gillin, J. C., Wu, J. C., Hazlett, E. A., Sicotte, N. L., Dupont, R. M., & Bunney, W. E. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90021-0 · Cited by 280 · see citing works
Bergsneider, M. D., Hovda, D. A., Lee, S. M., Kelly, D. F., McArthur, D. L., Vespa, P. M., Lee, J. H., Huang, S., Martin, N. A., Phelps, M. E., et al. (2000) · Journal of Neurotrauma · doi:10.1089/neu.2000.17.389 · Cited by 278 · see citing works
Goodman, J. C., Valadka, A. B., Gopinath, S. P., Uzura, M., & Robertson, C. S. (1999) · Critical Care Medicine · doi:10.1097/00003246-199909000-00041 · Cited by 266 · see citing works
Comparative evaluation of MR-based partial-volume correction schemes for PET.
MELTZER, C. C., Kinahan, P. E., Greer, P. J., Nichols, T. E., Comtat, C., Cantwell, M. N., Lin, M., & Price, J. C. (1999) · PubMed · Cited by 254 · see citing works
Functional neuroanatomy of hypnotic state
Maquet, P., Faymonville, M. E., Degueldre, C., Delfiore, G., Franck, G., Luxen, A., & Lamy, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00546-5 · Cited by 245 · see citing works
Guidelines for the Determination of Death
Rowland, L. P. (1982) · Neurology · doi:10.1212/wnl.32.4.395 · Cited by 243 · see citing works
Alkire, M. T. M., Haier, R. J. P., Shah, N. K. M., & Anderson, C. T. M. (1997) · Anesthesiology · doi:10.1097/00000542-199703000-00006 · Cited by 235 · see citing works
Quarantelli, M., Berkouk, K., Prinster, A., Landeau, B., Svarer, C., Balkay, L., Alfano, B., Brunetti, A., Baron, J., & Salvatore, M. (2004) · PubMed · Cited by 224 · see citing works
Alkire, M. T., Pomfrett, C. J. D., Haier, R. J., Gianzero, M. V., Chan, C. M., Jacobsen, B. P., & Fallon, J. H. (1999) · Anesthesiology · doi:10.1097/00000542-199903000-00011 · Cited by 221 · see citing works
Cortical processing in persistent vegetative state
Menon, D. K., Owen, A., Williams, E. J., Minhas, P., Allen, C., Boniface, S. J., & Pickard, J. (1998) · The Lancet · doi:10.1016/s0140-6736(05)77805-3 · Cited by 210 · see citing works
Self-citationBritish Medical Journal Publishing Group (1976) · BMJ · doi:10.1136/bmj.2.6045.1187 · Cited by 210 · see citing works
Bergsneider, M., Hovda, D. A., McArthur, D. L., Etchepare, M., Huang, S., Sehati, N., Satz, P., Phelps, M. E., & Becker, D. P. (2001) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200104000-00004 · Cited by 207 · see citing works
Cerebral metabolism during vegetative state and after recovery to consciousness
Laureys, S., Lemaire, C. F., Maquet, P., Phillips, C. L. M., & Franck, G. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.67.1.121 · Cited by 203 · see citing works
Self-citationDoes cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics?
Rossini, P. M. (2003) · Brain · doi:10.1093/brain/awh012 · Cited by 202 · see citing works
Caruncho, H. J. (2002) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(02)00002-9 · Cited by 197 · see citing works
Differences in cerebral blood flow and glucose utilization in vegetative versus locked‐in patients
Levy, D. E., Sidtis, J. J., Rottenberg, D. A., Jarden, J. O., Strother, S. C., DHAWAN, V. M., Ginos, J. Z., Tramo, M. J., Evans, A. C., & Plum, F. (1987) · Annals of Neurology · doi:10.1002/ana.410220602 · Cited by 195 · see citing works
European brain death codes: a comparison of national guidelines
Haupt, W. F., & Rudolf, J. (1999) · Journal of Neurology · doi:10.1007/s004150050378 · Cited by 184 · see citing works
Survey: The locked-in syndrome: a syndrome looking for a therapy
León‐Carrión, J., van Eeckhout, P., Domínguez-Morales, M. D. R., & Pérez-Santamaría, F. J. (2002) · Brain Injury · doi:10.1080/02699050110119781 · Cited by 171 · see citing works
Hovda, D. A., Becker, D. P., & Katayama, Y. (1992) · Journal of Neurotrauma · doi:10.1177/089771519200901s04 · Cited by 161 · see citing works
Hutchinson, P. J., Gupta, A. K., Fryer, T. D., Al-Rawi, P. G., Chatfield, D. A., Coles, J., O’Connell, M. T., Kett-White, R., Minhas, P. S., Aigbirhio, F. I., et al. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200206000-00012 · Cited by 161 · see citing works
Zeman, A. Z. (1997) · The Lancet · doi:10.1016/s0140-6736(97)06447-7 · Cited by 155 · see citing works
MELTZER, C. C., Zubieta, J. K., Links, J. M., Brakeman, P., Stumpf, M. J., & Frost, J. J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00016 · Cited by 143 · see citing works
Emotion processing in the minimally conscious state
Bekinschtein, T. A. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.034876 · Cited by 140 · see citing works
Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access
Fins, J. J. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1079 · Cited by 137 · see citing works
Brain Glucose Metabolism in Postanoxic Syndrome
Devolder, A. (1990) · Archives of Neurology · doi:10.1001/archneur.1990.00530020103022 · Cited by 130 · see citing works
Regional Cerebral Metabolism of Glucose in Comatose and Vegetative State Patients
Tommasino, C., Grana, C., Lucignani, G., Torri, G., & Fazio, F. (1995) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199504000-00006 · Cited by 127 · see citing works
The influence of extra- and intracranial artery disease on the BOLD signal in FMRI
Hamzei, F., Knab, R., Weiller, C., et al. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00384-7 · Cited by 116 · see citing works
Selective Metabolic Reduction in Gray Matter Acutely following Human Traumatic Brain Injury
Wu, H.-M., Huang, S., Hattori, N., Glenn, T. C., Vespa, P. M., Yu, C.-L., Hovda, D. A., Phelps, M. E., & Bergsneider, M. (2004) · Journal of Neurotrauma · doi:10.1089/089771504322778613 · Cited by 115 · see citing works
Hattori, N., Huang, S., Wu, H.-M., Yeh, E., Glenn, T. C., Vespa, P. M., McArthur, D. L., Phelps, M. E., Hovda, D. A., & Bergsneider, M. (2003) · PubMed · Cited by 115 · see citing works
The Vegetative State: Medical Facts, Ethical and Legal Dilemmas
Jennett, B. (2002) · Cambridge University Press eBooks · doi:10.1017/cbo9780511545535 · Cited by 114 · see citing works
Disorders of Consciousness: Differential Diagnosis and Neuropathologic Features
Giacino, J. T. (1997) · Seminars in Neurology · doi:10.1055/s-2008-1040919 · Cited by 112 · see citing works
Clinical Experience with Norethisterone and Norethisterone Acetate
Foss, G. L. (1960) · BMJ · doi:10.1136/bmj.2.5207.1187 · Cited by 112 · see citing works
de Jong, B. M., Willemsen, A. T. M., & Paans, A. M. J. (1997) · Clinical Neurology and Neurosurgery · doi:10.1016/s0303-8467(97)00024-3 · Cited by 110 · see citing works
Physiological imaging of the brain with PET
GJEDDE, A. H. (2001) · Cited by 108 · see citing works
Cerebral Glucose Metabolism in Acute and Persistent Vegetative State
Rudolf, J., Ghaemi, M., Ghaemi, M., Haupt, W. F., Szelies, B., & Heiss, W. (1999) · Journal of Neurosurgical Anesthesiology · doi:10.1097/00008506-199901000-00004 · Cited by 105 · see citing works
The diving bell and the butterfly
(1997) · Choice Reviews Online · doi:10.5860/choice.35-2016 · Cited by 102 · see citing works
Celesia (1993) · Annals of Neurology · doi:10.1002/ana.410330409 · Cited by 99 · see citing works
Regional Correction of Positron Emission Tomography Data for the Effects of Cerebral Atrophy
Videen, T. O., Perlmutter, J. S., Mintun, M. A., & Raichle, M. E. (1988) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1988.113 · Cited by 98 · see citing works
Correction of Positron Emission Tomography Data for Cerebral Atrophy
Herscovitch, P., Auchus, A. P., Gado, M. H., Chi, D., & Raichle, M. E. (1986) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1986.14 · Cited by 93 · see citing works
Research Involving Cognitively Impaired Adults
Karlawish, J. H. (2003) · New England Journal of Medicine · doi:10.1056/nejmsb030172 · Cited by 89 · see citing works
Clinical characteristics of patients in the persistent vegetative state.
Tresch, D. D., Sims, F. H., Duthie, E. H., Goldstein, M. D., & Lane, P. S. (1991) · PubMed · Cited by 88 · see citing works
Gsell, W., de Sadeleer, C., Marchalant, Y., MacKenzie, E. T., Schumann‐Bard, P., & Dauphin, F. (2000) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(00)00095-8 · Cited by 77 · see citing works
Laurin, N. R., Driedger, A. A., Hurwitz, G. A., et al. (1989) · PubMed · Cited by 76 · see citing works
Cognitive recovery from 'persistent vegetative state': psychological and personal perspectives
Wilson, B. A., & Gracey, F. (2001) · Brain Injury · doi:10.1080/02699050110082197 · Cited by 76 · see citing works
Schiff, N. D., Ribary, U., Plum, F., & Llinás, R. (1999) · Journal of Cognitive Neuroscience · doi:10.1162/089892999563715 · Cited by 75 · see citing works
Self-citationThe permanent vegetative state: practical guidance on diagnosis and management
Wade, D. T., & Johnston, C. (1999) · BMJ · doi:10.1136/bmj.319.7213.841 · Cited by 75 · see citing works
Yearbook of Intensive Care and Emergency Medicine 2001
(2001) · Springer eBooks · doi:10.1007/978-3-642-59467-0 · Cited by 75 · see citing works
Edgren, E., Enblad, P., Grenvik, A. N. A., et al. (2003) · Resuscitation · doi:10.1016/s0300-9572(03)00004-2 · Cited by 74 · see citing works
99mTc-HMPAO SPECT in the diagnosis of brain death
Facco, E., Zucchetta, P., Munari, M., et al. (1998) · Intensive Care Medicine · doi:10.1007/s001340050689 · Cited by 74 · see citing works
Tc-99m HMPAO Cerebral Scintigraphy A Reliable, Noninvaslve Method for Determination of Brain Death
Wieler, H. J., MAROHL, K., KAISER, K. P., et al. (1993) · Clinical Nuclear Medicine · doi:10.1097/00003072-199302000-00002 · Cited by 71 · see citing works
Voxel-Based Mapping of Brain Hypometabolism in Permanent Amnesia with PET
Aupée, A., Desgranges, B., Eustache, F., Lalevée, C., Sayette, V. D. L., Viader, F., & Baron, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0762 · Cited by 69 · see citing works
Hamlin, G. P., Černak, I., Wixey, J. A., et al. (2001) · Journal of Neurotrauma · doi:10.1089/08977150152693700 · Cited by 69 · see citing works
Cerebral perfusion and metabolism in resuscitated patients with severe post-hypoxic encephalopathy
Schaafsma, A. E., de Jong, B. M., Bams, J. L., Haaxma-Reiche, H., Pruim, J., & Zijlstra, J. G. (2003) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(03)00063-7 · Cited by 69 · see citing works
Clinical Characteristics of Patients in the Persistent Vegetative State
Tresch, D. D. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400050078015 · Cited by 67 · see citing works
Persistent vegetative state: evaluation of brain metabolism and brain perfusion with PET and SPECT
Beuthien‐Baumann, B., Handrïck, W., Schmidt, T. A., et al. (2003) · Nuclear Medicine Communications · doi:10.1097/00006231-200306000-00005 · Cited by 52 · see citing works
Ethical considerations for research in critically ill patients
Bigatello, L. M., George, E., & Hurford, W. E. (2003) · Critical Care Medicine · doi:10.1097/01.ccm.0000064518.50241.fa · Cited by 51 · see citing works
Electrophysiology in the locked-in-syndrome
Gütling, E., Isenmann, S., & Wichmann, W. W. (1996) · Neurology · doi:10.1212/wnl.46.4.1092 · Cited by 47 · see citing works
Developing prosthetics to treat cognitive disabilities resulting from acquired brain injuries
Schiff, N. D., Plum, F., & Rezai, A. R. (2002) · Neurological Research · doi:10.1179/016164102101199576 · Cited by 47 · see citing works
Self-citation99mTc HM-PAO brain perfusion SPECT in brain death
Bonetti, M. G., CIRITELLA, P., Valle, G., et al. (1995) · Neuroradiology · doi:10.1007/bf00588013 · Cited by 47 · see citing works
Cerebral hemodynamics and metabolism of severe diffuse brain injury measured by PET.
Yamaki, T., Imahori, Y., Ohmori, Y., Yoshino, E., Hohri, T., Ebisu, T., & Ueda, S. (1996) · PubMed · Cited by 47 · see citing works
Positron Emission Tomographic Studies on Cerebral Hemodynamics in Patients with Cerebral Contusion
Tenjin, H., Ueda, S., Mizukawa, N., Imahori, Y., Hino, A., Yamaki, T., Kuboyama, T., Ebisu, T., Hirakawa, K., Yamashita, M., et al. (1990) · Neurosurgery · doi:10.1097/00006123-199006000-00009 · Cited by 46 · see citing works
Identification by positron emission tomography of neuronal loss in acute vegetative state
Rudolf, J., Sobesky, J., Grond, M., et al. (2000) · The Lancet · doi:10.1016/s0140-6736(99)04280-4 · Cited by 46 · see citing works
Persistent vegetative state with high cerebral blood flow following profound hypoglycemia
Agardh, C. –., Rosén, I., & Ryding, E. (1983) · Annals of Neurology · doi:10.1002/ana.410140414 · Cited by 42 · see citing works
PET scanning and neuronal loss in acute vegetative state
Laureys, S., Faymonville, M., Moonen, G., Luxen, A., & Maquet, P. (2000) · The Lancet · doi:10.1016/s0140-6736(05)73084-1 · Cited by 42 · see citing works
Self-citationPositron Emission Tomographic Studies on Cerebral Hemodynamics in Patients with Cerebral Contusion
Tenjin, H., Ueda, S., Mizukawa, N., et al. (1990) · Neurosurgery · doi:10.1227/00006123-199006000-00009 · Cited by 40 · see citing works
Analysing brain images: principles and overview
Friston, K. J. (1997) · UCL Discovery (University College London) · Cited by 38 · see citing works
THE VEGETATIVE STATE: MEDICAL FACTS, ETHICAL AND LEGAL DILEMMAS
Howard, R. (2002) · Brain · doi:10.1093/brain/awf262 · Cited by 37 · see citing works
The Boundaries of the Persistent Vegetative State
Bernat, J. L. (1992) · The Journal of Clinical Ethics · doi:10.1086/jce199203302 · Cited by 35 · see citing works
Contemporary theories of consciousness.
Zeman, A. Z., Grayling, A. C., & Cowey, A. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.62.6.549 · Cited by 34 · see citing works
Momose, T., Matsui, T., Kosaka, N., et al. (1990) · PubMed · Cited by 33 · see citing works
Meyer, M. (1996) · Journal of Neuroimaging · doi:10.1111/jon199662117 · Cited by 33 · see citing works
Rudolf, J., Sobesky, J., Ghaemi, M., et al. (2002) · European Journal of Neurology · doi:10.1046/j.1468-1331.2002.00468.x · Cited by 27 · see citing works
99m'Tc-HEXAMETHYLPROPYLENEAMINE OXIME SCANS TO CONFIRM BRAIN DEATH
Roine, R., Launes, J., Lindroth, L., et al. (1986) · The Lancet · doi:10.1016/s0140-6736(86)92237-3 · Cited by 25 · see citing works
BOLD functional MRI may overlook activation areas in the damaged brain
Sakatani, K., Murata, Y., Fukaya, C., Yamamoto, T., & Katayama, Y. (2003) · Springer eBooks · doi:10.1007/978-3-7091-6081-7_13 · Cited by 22 · see citing works
Assessing Consciousness in Critically Ill Patients
Laureys, S., Majerus, S., & Moonen, G. (2002) · Intensive Care Medicine · doi:10.1007/978-1-4757-5551-0_64 · Cited by 20 · see citing works
Self-citation99mTc-HMPAO cerebral scintigraphy in the diagnosis of brain death.
Yatim, A., Mercatello, A., Coronel, B., et al. (1991) · PubMed · Cited by 20 · see citing works
Laureys, S., Berré, J., Elincx, S., et al. (2001) · NeuroImage · doi:10.1016/s1053-8119(01)92148-2 · Cited by 17 · see citing works
Self-citationImpaired Cerebral Connectivity in Vegetative State
Laureys, S., Faymonville, M.-É., Goldman, S., Degueldre, C., Phillips, C. L. M., Lambermont, B. C., Aerts, J. J., Lamy, M., Luxen, A., Franck, G., et al. (2001) · Elsevier eBooks · doi:10.1016/b978-012285751-5/50050-8 · Cited by 13 · see citing works
Self-citationThe ‘locked-in’ syndrome – comments from a survivor
Ostrum, A. E. (1994) · Brain Injury · doi:10.3109/02699059409150962 · Cited by 12 · see citing works
Shelley, W. B. (1970) · Archives of Dermatology · doi:10.1001/archderm.1970.04000090001001 · Cited by 11 · see citing works
Health, happiness, and a good night's sleep
Hargreaves, S. (2000) · The Lancet · doi:10.1016/s0140-6736(05)72075-4 · Cited by 10 · see citing works
Research Ethics in Head Trauma Rehabilitation
Phipps, E. (2000) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-200006000-00010 · Cited by 5 · see citing works
Neurologists say Florida woman is very unlikely to recover
Oransky, I. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00600-8 · Cited by 4 · see citing works
Only the Eyes Say Yes: A Love Story
Vigand, P. (2000) · Medical Entomology and Zoology · Cited by 3 · see citing works
Flagged first, then by citations
Research works printed but not linked: 5
- [12]12. Steriade M, Jones EG, McCormick D. Thalamus. Amsterdam ; New York: Elsevier, 1997. 28
- [17]17. Medical Royal Colleges and their Faculties in the United Kingdom. Diagnosis of brain death. B.M.J. 1976; 2: 1187-8.
- [35]35. Roine RO, Launes J, Lindroth L, Nikkinen P. 99mTc-hexamethylpropyleneamine oxime scans to confirm brain death. Lancet 1986; 2: 1223-4.
- [82]82. Salmon E, Collette F, Degueldre C, Lemaire C, Franck G. Voxel-based analysis of confounding effects of age and dementia severity on cerebral metabolism in Alzheimer's disease [In Process Citation]. Hum Brain Mapp 2000; 10: 39-48.
- [87]87. Hirsch J, Kamal A, Moreno D, Petrovich N, Giacino J, Plum F, Schiff N. fMRI reveals intact cognitive systems for two minimally conscious patients. Society for Neuroscience, Abstracts 2001; 271: 1397.
Cited by
Sorted by citations
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Dehaene, S., & Changeux, J.-P. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.018 · Cited by 2,573 · see citing works
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Leech, R., & Sharp, D. J. (2014) · Brain · doi:10.1093/brain/awt162 · Cited by 2,247 · see citing works
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From presence to consciousness through virtual reality.
Sanchez-Vives, M. V., & Slater, M. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1651 · Cited by 1,831 · see citing works
Neural correlates of consciousness: progress and problems
Koch, C., Massimini, M., Boly, M., & Tononi, G. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.22 · Cited by 1,600 · see citing works
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Massimini, M., Ferrarelli, F., Huber, R., Esser, S. K., Singh, H., & Tononi, G. (2005) · Science · doi:10.1126/science.1117256 · Cited by 1,534 · see citing works
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Self-citationVanhaudenhuyse, A., Noirhomme, Q., Tshibanda, L. J.-F., Bruno, M.-A., Boveroux, P., Schnakers, C., Soddu, A., Perlbarg, V., Ledoux, D., Brichant, J.-F., et al. (2010) · Brain · doi:10.1093/brain/awp313 · Cited by 911 · see citing works
Self-citationRecovery of consciousness after brain injury: a mesocircuit hypothesis
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Self-citationREM sleep and dreaming: towards a theory of protoconsciousness
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Self-citationSimeral, J. D., Kim, S.-P., Black, M. J., Donoghue, J. P., & Hochberg, L. R. (2011) · Journal of Neural Engineering · doi:10.1088/1741-2560/8/2/025027 · Cited by 496 · see citing works
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Self-citationKübler, A., & Birbaumer, N. (2008) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.06.019 · Cited by 441 · see citing works
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Xie, G., Deschamps, A., Backman, S. B., Fiset, P., Chartrand, D., Dagher, A., & Plourde, G. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aeq415 · Cited by 99 · see citing works
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Silva, S., Alacoque, X., Fourcade, O., Samii, K., Marque, P., Woods, R., Mazziotta, J., Chollet, F., & Loubinoux, I. (2010) · Neurology · doi:10.1212/wnl.0b013e3181cbcd96 · Cited by 90 · see citing works
Subject's own name as a novel in a MMN design: A combined ERP and PET study
Holeckova, I., Fischer, C., Morlet, D., Delpuech, C., Costes, N., & Mauguière, F. (2008) · Brain Research · doi:10.1016/j.brainres.2007.10.091 · Cited by 76 · see citing works
Bettinardi, R. G., Tort-Colet, N., Ruiz-Mejias, M., Sanchez-Vives, M. V., & Deco, G. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.03.037 · Cited by 68 · see citing works
Phillips, W. A., Bachmann, T., & Storm, J. F. (2018) · Frontiers in Neural Circuits · doi:10.3389/fncir.2018.00050 · Cited by 62 · see citing works
Bruno, M. A., Fernández-Espejo, D., Lehembre, R., Tshibanda, L., Vanhaudenhuyse, A., Gosseries, O., Lommers, E., Napolitani, M., Noirhomme, Q., Boly, M., et al. (2011) · Progress in Brain Research · doi:10.1016/b978-0-444-53839-0.00021-1 · Cited by 59 · see citing works
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Hermann, B., Sangaré, A., Munoz-Musat, E., Salah, A. B., Perez, P., Valente, M., Faugeras, F., Axelrod, V., Demeret, S., Marois, C., et al. (2021) · Neuroscience of Consciousness · doi:10.1093/nc/niab048 · Cited by 24 · see citing works
Mäki-Marttunen, V., Castro, M., Olmos, L., Leiguarda, R., & Villarreal, M. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.01.022 · Cited by 13 · see citing works
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Self-citationStucky, B. (2025) · Nature and Science of Sleep · doi:10.2147/nss.s506461 · Cited by 7 · see citing works
- Authors
- Laureys, S., Owen, A. M., & Schiff, N. D.
- Affiliations
- University of Liège (BE)
- MRC Cognition and Brain Sciences Unit (GB)
- Cornell University (US)
- Corresponding author
- Laureys, Steven
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 3
- Issue
- 9
- Pages
- 537-546
- ISSN
- 1474-4422 (ISSN-L)
- OpenAlex
- W2110954320
- Cited by
- 1,033
- References
- 122
- Citations by year
- 2026: 37 · 2025: 31 · 2024: 38 · 2023: 40 · 2022: 37 · 2021: 44 · 2020: 32 · 2019: 37 · 2018: 46 · 2017: 54 · 2016: 55 · 2015: 64 · 2014: 62 · 2013: 47 · 2012: 71
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- green
- orbi.uliege.be
- Licence
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- ORBi (University of Liège) (submittedVersion, other-oa)
- Funders
- Dana Foundation
- Mind Science Foundation
- Fonds De La Recherche Scientifique - FNRS
- Université de Liège
- Fondation Médicale Reine Elisabeth
- National Institute of Neurological Disorders and Stroke (K02NS002172, NS02172, R21NS043451, NS43451)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- coma, vegetative state, minimally conscious state, locked-in state, brain death, severe brain damage, brain metabolism, functional neuroimaging, prognosis, research ethics
- MeSH terms
- Brain, Brain Death, Diagnostic Imaging, Humans, Quadriplegia, Persistent Vegetative State, Point-of-Care Systems
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