Functional evolution of Erg potassium channel gating reveals an ancient origin for I Kr

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works

A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Sanguinetti, M. C., Jiang, C., Curran, M. E., & Keating, M. T. (1995) · Cell · doi:10.1016/0092-8674(95)90340-2 · Cited by 2,422 · see citing works

The Genome Sequence of the Malaria Mosquito Anopheles gambiae

Holt, R. A., Subramanian, G., Halpern, A. L., Sutton, G. G., Charlab, R., Nusskern, D. R., Wincker, P., Clark, A. G., Ribeiro, J. M. C., Wides, R., et al. (2002) · Science · doi:10.1126/science.1076181 · Cited by 2,018 · see citing works

Evolution of genes and genomes on the Drosophila phylogeny

Drosophila 12 Genomes Consortium (2007) · Nature · doi:10.1038/nature06341 · Cited by 2,010 · see citing works

Broad phylogenomic sampling improves resolution of the animal tree of life

Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921 · cited 3× · see citing works

hERG potassium channels and cardiac arrhythmia

Sanguinetti, M. C., & Tristani‐Firouzi, M. (2006) · Nature · doi:10.1038/nature04710 · Cited by 1,582 · see citing works

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555 · see citing works

HERG, a Human Inward Rectifier in the Voltage-Gated Potassium Channel Family

Trudeau, M. C., Warmke, J. W., Ganetzky, B., & Robertson, G. A. (1995) · Science · doi:10.1126/science.7604285 · Cited by 1,241 · see citing works

Molecular and Cellular Mechanisms of Cardiac Arrhythmias

Keating, M. T., & Sanguinetti, M. C. (2001) · Cell · doi:10.1016/s0092-8674(01)00243-4 · Cited by 1,003 · see citing works

A family of potassium channel genes related to eag in Drosophila and mammals.

Warmke, J. W., & Ganetzky, B. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.8.3438 · Cited by 986 · see citing works

The Genome Sequence of Caenorhabditis briggsae: A Platform for Comparative Genomics

Stein, L. D., Bao, Z., Blasiar, D., Blumenthal, T., Brent, M. R., Chen, N., Chinwalla, A., Clarke, L., Clee, C. M., Coghlan, A., et al. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000045 · Cited by 931 · see citing works

Inactivation properties of voltage-gated K+ channels altered by presence of β-subunit

Rettig, J., Heinemann, S. H., Wunder, F., Lorra, C., Parcej, D. N., Dolly, J. O., & Pongs, O. (1994) · Nature · doi:10.1038/369289a0 · Cited by 853 · see citing works

Sudden death associated with short-QT syndrome linked to mutations in HERG

Brugada, R., Hong, K., Dumaine, R., Cordeiro, J., Gaita, F., Borggrefe, M., Menendez, T. M., Brugada, J., Pollevick, G. D., Wolpert, C., et al. (2004) · Circulation · doi:10.1161/01.cir.0000109482.92774.3a · Cited by 847 · see citing works

painless, a Drosophila Gene Essential for Nociception

Tracey, W. D., Wilson, R. I., Laurent, G., & Benzer, S. (2003) · Cell · doi:10.1016/s0092-8674(03)00272-1 · Cited by 833 · see citing works

The inward rectification mechanism of the HERG cardiac potassium channel

Smith, P. L., Baukrowitz, T., & Yellen, G. (1996) · Nature · doi:10.1038/379833a0 · Cited by 753 · see citing works

Assessing the root of bilaterian animals with scalable phylogenomic methods

Hejnol, A., Obst, M., Stamatakis, A., Ott, M., Rouse, G. W., Edgecombe, G. D., Martinez, P., Baguñà, J., Bailly, X., Jondelius, U., et al. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.0896 · Cited by 747 · cited 3× · see citing works

Temporal Patterns of Fruit Fly (Drosophila) Evolution Revealed by Mutation Clocks

Tamura, K. (2003) · Molecular Biology and Evolution · doi:10.1093/molbev/msg236 · Cited by 574 · see citing works

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis

Yu, F. H., & Catterall, W. A. (2004) · Science s STKE · doi:10.1126/stke.2532004re15 · Cited by 473 · see citing works

Crystal Structure and Functional Analysis of the HERG Potassium Channel N Terminus

Morais-Cabral, J. H., Lee, A., Cohen, S. L., Chait, B. T., Li, M., & MacKinnon, R. (1998) · Cell · doi:10.1016/s0092-8674(00)81635-9 · Cited by 436 · see citing works

Expression of functional potassium channels from Shaker cDNA in Xenopus oocytes

Timpe, L. C., Schwarz, T. L., Tempel, B. L., Papazian, D. M., Jan, Y. N., & Jan, L. Y. (1988) · Nature · doi:10.1038/331143a0 · Cited by 387 · see citing works

An essential ‘set’ of K+ channels conserved in flies, mice and humans

Salkoff, L., Baker, K. H., Butler, A., Covarrubias, M., Pak, M. D., & Wei, A. D. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90165-5 · Cited by 306 · see citing works

Two Isoforms of the Mouse Ether-a-go-go –Related Gene Coassemble to Form Channels With Properties Similar to the Rapidly Activating Component of the Cardiac Delayed Rectifier K + Current

London, B., Trudeau, M. C., Newton, K. P., Beyer, A. K., Copeland, N. G., Gilbert, D. J., enkins, N. A. J., Satler, C. A., & Robertson, G. A. (1997) · Circulation Research · doi:10.1161/01.res.81.5.870 · Cited by 296 · see citing works

Eight Potassium Channel Families Revealed by the C. elegans Genome Project

Wei, A. D., Jegla, T. J., & Salkoff, L. (1996) · Neuropharmacology · doi:10.1016/0028-3908(96)00126-8 · Cited by 251 · see citing works

Identification of Two Nervous System-Specific Members of theergPotassium Channel Gene Family

Shi, W., Wymore, R. S., Wang, H.-S., Pan, Z., Cohen, I. S., McKinnon, D. H., & Dixon, J. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-24-09423.1997 · Cited by 229 · see citing works

Chromosomal Rearrangement Inferred From Comparisons of 12 Drosophila Genomes

Bhutkar, A. J., Schaeffer, S. W., Russo, S. M., Xu, M., Smith, T. F., & Gelbart, W. M. (2008) · Genetics · doi:10.1534/genetics.107.086108 · Cited by 214 · see citing works

Diverse behavioural defects caused by mutations in Caenorhabditis elegans unc-43 CaM Kinase II

Reiner, D. J., Newton, E. M., Tian, H., & Thomas, J. H. (1999) · Nature · doi:10.1038/46072 · Cited by 130 · see citing works

Low Birth Weight and Increased Sympathetic Activity

Weitz, G., Fehm, H. L., & Dodt, C. (2004) · Circulation · doi:10.1161/01.cir.0000115205.70330.05 · Cited by 126 · see citing works

Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E‐4031 from HERG to M‐eag channels

Herzberg, I. M., Trudeau, M. C., & Robertson, G. A. (1998) · The Journal of Physiology · doi:10.1111/j.1469-7793.1998.003bi.x · Cited by 124 · see citing works

The structural mechanism of KCNH-channel regulation by the eag domain

Haitin, Y., Carlson, A. E., & Zagotta, W. N. (2013) · Nature · doi:10.1038/nature12487 · Cited by 123 · see citing works

Evolution of the Human Ion Channel Set

Nayak, S. K., Batalov, S., Jegla, T. J., & Zmasek, C. M. (2009) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/138620709787047957 · Cited by 116 · see citing works

TheDrosophila ergK+Channel Polypeptide Is Encoded by the Seizure Locus

Titus, S. A., Warmke, J. W., & Ganetzky, B. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-03-00875.1997 · Cited by 106 · see citing works

CCA-1, EGL-19 and EXP-2 currents shape action potentials in theCaenorhabditis eleganspharynx

Shtonda, B. B., & Avery, L. (2005) · Journal of Experimental Biology · doi:10.1242/jeb.01615 · Cited by 97 · see citing works

Co-chaperone FKBP38 Promotes HERG Trafficking

Walker, V. E., Atanasiu, R., Lam, H. D., & Shrier, A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701006200 · Cited by 96 · see citing works

A Novel Subunit for Shal K+Channels Radically Alters Activation and Inactivation

Jegla, T. J., & Salkoff, L. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00032.1997 · Cited by 80 · see citing works

Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy

Zhang, X., Bertaso, F., Yoo, J. W., Baumgärtel, K., Clancy, S. M., Lee, V., Cienfuegos, C., Wilmot, C., Avis, J., Hunyh, T., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2610 · Cited by 80 · see citing works

Structure of the C-terminal region of an ERG channel and functional implications

Brelidze, T. I., Gianulis, E. C., DiMaio, F., Trudeau, M. C., & Zagotta, W. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1306887110 · Cited by 66 · see citing works

A Mutation in the C. elegans EXP-2 Potassium Channel That Alters Feeding Behavior

Davis, M. W., Fleischhauer, R., Dent, J. A., Joho, R. H., & Avery, L. (1999) · Science · doi:10.1126/science.286.5449.2501 · Cited by 59 · see citing works

Caenorhabditis elegansUNC-103 ERG-Like Potassium Channel Regulates Contractile Behaviors of Sex Muscles in Males before and during Mating

Garcia, L. R., & Sternberg, P. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02696.2003 · Cited by 58 · see citing works

Postsynaptic ERG Potassium Channels Limit Muscle Excitability to Allow Distinct Egg-Laying Behavior States inCaenorhabditis elegans

Collins, K. M., & Koelle, M. R. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3896-12.2013 · Cited by 58 · see citing works

Multiple Shaker potassium channels in a primitive metazoan

Jegla, T. J., Grigoriev, N. G., Gallin, W. J., Salkoff, L., & Spencer, A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-12-07989.1995 · Cited by 51 · see citing works

Functional Analysis of a Mouse Brain Elk-Type K+Channel

Trudeau, M. C., Titus, S. A., Branchaw, J. L., Ganetzky, B., & Robertson, G. A. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02906.1999 · Cited by 46 · see citing works

Expanded Functional Diversity of Shaker K+ Channels in Cnidarians Is Driven by Gene Expansion

Jegla, T., Marlow, H. Q., Chen, B., Simmons, D. K., Jacobo, S. M., & Martindale, M. Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051366 · Cited by 35 · see citing works

Cloning and functional expression of voltage-gated ion channel subunits from cnidocytes of the Portuguese Man O'War Physalia physalis

Bouchard, C., Price, R. B., Moneypenny, C. G., Thompson, L. F., Zillhardt, M., Stalheim, L., & Anderson, P. A. V. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02314 · Cited by 25 · see citing works

Cell Excitability Necessary for Male Mating Behavior in Caenorhabditis elegans Is Coordinated by Interactions Between Big Current and Ether-A-Go-Go Family K+ Channels

LeBoeuf, B., & Garcia, L. R. (2011) · Genetics · doi:10.1534/genetics.111.137455 · Cited by 22 · see citing works

jShaw1, a low-threshold, fast-activating Kv3 from the hydrozoan jellyfishPolyorchis penicillatus

Sand, R. M., Atherton, D. M., Spencer, A. N., & Gallin, W. J. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.057000 · Cited by 15 · see citing works

A Drosophila behavioral mutant, down and out ( dao ), is defective in an essential regulator of Erg potassium channels

Fergestad, T., Sale, H., Bostwick, B. L., Schaffer, A., Ho, L., Robertson, G. A., & Ganetzky, B. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001494107 · Cited by 11 · see citing works

Zebrafish heart as a model for human cardiac electrophysiology

Vornanen, M., & Hassinen, M. (2015) · Channels · doi:10.1080/19336950.2015.1121335 · Cited by 148 · see citing works

Evolution of voltage-gated ion channels at the emergence of Metazoa

Moran, Y., Barzilai, M. G., Liebeskind, B. J., & Zakon, H. H. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110270 · Cited by 139 · see citing works

Evolution of eumetazoan nervous systems: insights from cnidarians

Kelava, I., Rentzsch, F., & Technau, U. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2015.0065 · Cited by 84 · see citing works

Neuronal polarity: an evolutionary perspective

Rolls, M. M., & Jegla, T. J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.112359 · Cited by 78 · see citing works

Convergence of ion channel genome content in early animal evolution

Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501195112 · Cited by 76 · see citing works

Complex Homology and the Evolution of Nervous Systems

Liebeskind, B. J., Hillis, D. M., Zakon, H. H., & Hofmann, H. A. (2015) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2015.12.005 · Cited by 67 · see citing works

The Evolution of the Four Subunits of Voltage-Gated Calcium Channels: Ancient Roots, Increasing Complexity, and Multiple Losses

Moran, Y., & Zakon, H. H. (2014) · Genome Biology and Evolution · doi:10.1093/gbe/evu177 · Cited by 50 · see citing works

Evolution of Animal Neural Systems

Liebeskind, B. J., Hofmann, H. A., Hillis, D. M., & Zakon, H. H. (2017) · Annual Review of Ecology Evolution and Systematics · doi:10.1146/annurev-ecolsys-110316-023048 · Cited by 52 · see citing works

The Enigmatic Cytoplasmic Regions of KCNH Channels

Morais-Cabral, J. H., & Robertson, G. A. (2014) · Journal of Molecular Biology · doi:10.1016/j.jmb.2014.08.008 · Cited by 42 · see citing works

Genome-Wide Association and Prediction of Traits Related to Salt Tolerance in Autotetraploid Alfalfa (Medicago sativa L.)

Medina, C. A., Hawkins, C. L., Liu, X., Peel, M. D., & Yu, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093361 · Cited by 42 · see citing works

Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment

Jegla, T. J., Nguyen, M. M., Feng, C., Goetschius, D. J., Luna, E., van Rossum, D. B., Kamel, B., Pisupati, A., Milner, E. S., & Rolls, M. M. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006457 · Cited by 40 · see citing works

Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian–bilaterian ancestor

Li, X., Martinson, A. S., Layden, M. J., Diatta, F. H., Sberna, A. P., Simmons, D. K., Martindale, M. Q., & Jegla, T. J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110080 · Cited by 36 · see citing works

Modern genomic tools reveal the structural and cellular diversity of cnidarian nervous systems

Rentzsch, F., Juliano, C. E., & Galliot, B. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2018.12.004 · Cited by 36 · see citing works

Antagonistic BMP–cWNT signaling in the cnidarian Nematostella vectensis reveals insight into the evolution of mesoderm

Wijesena, N. M., Simmons, D. K., & Martindale, M. Q. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1701607114 · Cited by 36 · see citing works

Genomics and development of Nematostella vectensis and other anthozoans

Rentzsch, F., & Technau, U. (2016) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2016.05.024 · Cited by 32 · see citing works

Major diversification of voltage-gated K + channels occurred in ancestral parahoxozoans

Li, X., Liu, H., Luo, J. C., Rhodes, S. A., Trigg, L., van Rossum, D. B., Anishkin, A., Diatta, F. H., Sassic, J. K., Simmons, D. K., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1422941112 · Cited by 31 · see citing works

Functional Characterization of Cnidarian HCN Channels Points to an Early Evolution of Ih

Baker, E. C., Layden, M. J., van Rossum, D. B., Kamel, B., Medina, M., Simpson, E., & Jegla, T. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142730 · Cited by 23 · see citing works

Bimodal regulation of an Elk subfamily K+ channel by phosphatidylinositol 4,5-bisphosphate

Li, X., Anishkin, A., Liu, H., van Rossum, D. B., Chintapalli, S. V., Sassic, J. K., Gallegos, D., Pivaroff-Ward, K., & Jegla, T. J. (2015) · The Journal of General Physiology · doi:10.1085/jgp.201511491 · Cited by 24 · see citing works

The S6 gate in regulatory Kv6 subunits restricts heteromeric K+ channel stoichiometry

Pisupati, A., Mickolajczyk, K. J., Horton, W., van Rossum, D. B., Anishkin, A., Chintapalli, S. V., Li, X., Luo, J. C., Busey, G. W., Hancock, W. O., et al. (2018) · The Journal of General Physiology · doi:10.1085/jgp.201812121 · Cited by 23 · see citing works

Enhancement of hERG channel activity by scFv antibody fragments targeted to the PAS domain

Harley, C. A., Starek, G., Jones, D. K., Fernandes, A. S., Robertson, G. A., & Morais-Cabral, J. H. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601116113 · Cited by 22 · see citing works

RNA-Seq Transcriptome Analysis of Direction-Selective T4/T5 Neurons in Drosophila

Pankova, K., & Borst, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0163986 · Cited by 21 · see citing works

Effective Perturbations on the Amplitude and Hysteresis of Erg-Mediated Potassium Current Caused by 1-Octylnonyl 8-[(2-hydroxyethyl)[6-oxo-6(undecyloxy)hexyl]amino]-octanoate (SM-102), a Cationic Lipid

Cho, H., Chuang, T.-H., & Wu, S. (2021) · Biomedicines · doi:10.3390/biomedicines9101367 · Cited by 17 · see citing works

Effective Perturbations by Small-Molecule Modulators on Voltage-Dependent Hysteresis of Transmembrane Ionic Currents

Wu, S., Wu, C., Cho, H., & Chiang, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169453 · Cited by 16 · see citing works

Genome-Scale Analysis Reveals Extensive Diversification of Voltage-Gated K+ Channels in Stem Cnidarians

Lara, A., Simonson, B. T., Ryan, J. F., & Jegla, T. J. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad009 · Cited by 15 · see citing works

An ancestral TMEM16 homolog from Dictyostelium discoideum forms a scramblase

Pelz, T., Drose, D. R., Fleck, D., Henkel, B., Ackels, T., Spehr, M., & Neuhaus, E. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191219 · Cited by 15 · see citing works

Characterization of Convergent Suppression by UCL-2077 (3-(Triphenylmethylaminomethyl)pyridine), Known to Inhibit Slow Afterhyperpolarization, of erg-Mediated Potassium Currents and Intermediate-Conductance Calcium-Activated Potassium Channels

Hsu, H., Lo, Y., & Wu, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041441 · Cited by 15 · see citing works

Voltage-gated ion channel diversity underlies neuronal excitability and nervous system evolution

Dávila-Velderrain, J., & van Giesen, L. (2025) · Nature Communications · doi:10.1038/s41467-025-66641-8 · Cited by 14 · see citing works

A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K + channels in animals

Jegla, T. J., Simonson, B. T., & Spafford, J. D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407461121 · Cited by 11 · see citing works

Cytoskeletal and synaptic polarity of LWamide-like+ ganglion neurons in the sea anemone Nematostella vectensis

Stone, M. C., Kothe, G. O., Rolls, M. M., & Jegla, T. J. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.233197 · Cited by 12 · see citing works

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

Jain, A., Stack, O., Ghodrati, S., Sanchez-Conde, F. G., Ukachukwu, C. U., Salwi, S. M., Jiménez‐Vázquez, E. N., & Jones, D. K. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2214700120 · Cited by 11 · see citing works

An intracellular hydrophobic nexus critical for hERG1 channel slow deactivation

Stevens-Sostre, W. A., Flores-Aldama, L., Bustos, D., Li, J., Morais-Cabral, J. H., Delemotte, L., & Robertson, G. A. (2024) · Biophysical Journal · doi:10.1016/j.bpj.2024.01.010 · Cited by 11 · see citing works

Characterization of the Synergistic Inhibition of IK(erg) and IK(DR) by Ribociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor

Liu, P.-Y., Chang, W., & Wu, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218078 · Cited by 9 · see citing works

The Effectiveness of Isoplumbagin and Plumbagin in Regulating Amplitude, Gating Kinetics, and Voltage-Dependent Hysteresis of erg-mediated K+ Currents

Chen, L., Cho, H., Chuang, T.-H., Ke, T.-L., & Wu, S. (2022) · Biomedicines · doi:10.3390/biomedicines10040780 · Cited by 9 · see citing works

Origin and Evolution of Nervous Systems

Layden, M. J. (2019) · Fascinating life sciences · doi:10.1007/978-3-030-18202-1_8 · Cited by 8 · see citing works

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels

Simonson, B. T., Jiang, Z., Ryan, J. F., & Jegla, T. J. (2025) · The Journal of General Physiology · doi:10.1085/jgp.202413740 · Cited by 6 · see citing works

Emerging models: The “development” of the ctenophore Mnemiopsis leidyi and the cnidarian Nematostella vectensis as useful experimental models

Martindale, M. Q. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.02.002 · Cited by 4 · see citing works

Acepromazine inhibits hERG potassium ion channels expressed in human embryonic kidney 293 cells

Joo, Y. S., Lee, H. J., Choi, J., & Sung, K.-W. (2017) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2017.21.1.75 · Cited by 4 · see citing works

How an intrinsic ligand tunes the activity of a potassium channel

Khoo, K. K., & Pless, S. A. (2018) · The Journal of General Physiology · doi:10.1085/jgp.201812011 · Cited by 3 · see citing works

Evaluation of suitable temperature range for post‐harvest processing of mud crabs through cardiac performance

Tsai, M., Hsu, W., & Chen, T. (2019) · Aquaculture Research · doi:10.1111/are.14331 · Cited by 3 · see citing works

Efficient expression of a cnidarian peptide-gated ion channel in mammalian cells

Bachmann, M., Ortega-Ramírez, A., Leisle, L., & Gründer, S. (2021) · Channels · doi:10.1080/19336950.2021.1882762 · Cited by 3 · see citing works

Neurite branching is associated with mixed microtubule polarity in sea anemone neurons

Stone, M. C., Kothe, G. O., Jegla, T. J., & Rolls, M. M. (2025) · Journal of Experimental Biology · doi:10.1242/jeb.251169 · Cited by 2 · see citing works

Modulation of INa, Ih, and IK(erg) by Extracellular or Intracellular QX-314 (N-(2,6-dimethylphenylcarbamoylmethyl) triethylammonium bromide) in Pituitary Tumor Cells

Wang, J. C.-F., Hsiao, H., & Wu, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178469 · Cited by 1 · see citing works

Diffuse pacemaker mechanism with distinctive organization drives pulsation in the octocoral Xenia umbellata

Nadir, E., Benayahu, Y., Ofek‐Lalzar, M., Gabrieli, T., & Lotan, T. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2500611122 · Cited by 1 · see citing works

Modulatory Effects of Bioactive Phytoconstituents on the Amplitude and Gating Properties of Membrane Ion Channels

Wu, S., Froldi, G., Wang, Y., & Liutkevičienė, R. (2026) · Molecules · doi:10.3390/molecules31081360 · Cited by 1 · see citing works

Inhibitory Perturbations of Fluvastatin on Afterhyperpolarization Current, Erg-mediated K+ Current, and Hyperpolarization-activated Cation Current in Both Pituitary GH3 Cells and Primary Embryonic Mouse Cortical Neurons

Wang, Y., Yeh, C., Gao, Z., Hwang, E., Chen, H., & Wu, S. (2023) · Neuroscience · doi:10.1016/j.neuroscience.2023.08.038 · Cited by 1 · see citing works

Structural Determinants and Biophysical Properties of hERG1 Channel Gating

Sanguinetti, M. C., & Sachse, F. B. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-44733-1.00012-2 · Cited by 1 · see citing works

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Jiang, Z., Kopri, N., Zurnachyan, A., & Jegla, T. J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.21.677649 · Cited by 1 · see citing works

Structural Determinants and Biophysical Properties of hERG1 Channel Gating

Sanguinetti, M. C., Tristani‐Firouzi, M., & Sachse, F. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4557-2856-5.00012-1

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Simonson, B. T., Jiang, Z., Ryan, J. F., & Jegla, T. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.09.627618

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Andersen, M. K., Livingston, D. B. H., Robertson, R. M., & MacMillan, H. A. (2026) · Comparative Biochemistry and Physiology Part A Molecular & Integrative Physiology · doi:10.1016/j.cbpa.2026.111969 · Cited by 3 · see citing works

Ether-à-go-go family voltage-gated K+ channels evolved in an ancestral metazoan and functionally diversified in a cnidarian–bilaterian ancestor

Li, X., Martinson, A. S., Layden, M. J., Diatta, F. H., Sberna, A. P., Simmons, D. K., Martindale, M. Q., & Jegla, T. J. (2015) · Journal of Experimental Biology · doi:10.1242/jeb.110080 · Cited by 36 · see citing works

Emerging roles for ether‐á‐go‐go‐related gene potassium channels in the brain

Shepard, P. D., & Trudeau, M. C. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.162669 · Cited by 2 · see citing works

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Lara, A., Simonson, B. T., Ryan, J. F., & Jegla, T. J. (2023) · Genome Biology and Evolution · doi:10.1093/gbe/evad009 · Cited by 15 · see citing works

The Eag Domain Regulates the Voltage-Dependent Inactivation of Rat Eag1 K+ Channels

Jeng, J. (2016)

Electrophysiological characterization of the Drosophila ERG K+ channel

Salinas, S. (n.d.)