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Cited by 260

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Open access
Adlanmerini, Marine, Solinhac, Romain, Abot, Anne, Fabre, Aurélie, Raymond-Letron, Isabelle, Guihot, Anne-Laure, Boudou, Frédéric, Sautier, Lucile, Vessières, Emilie, Kim, Sung Hoon, Lière, Philippe, Fontaine, Coralie, Krust, Andrée, Chambon, Pierre, Katzenellenbogen, John A., Gourdy, Pierre, Shaul, Philip W., Henrion, Daniel, Arnal, Jean-François, Lenfant, Françoise·2014·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1322057111
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Abstract

Significance: The in vivo roles of plasma membrane-associated estrogen receptor (ER)α, including cross-talk with nuclear ERα, are poorly understood. We created a mouse with a point mutation of the palmitoylation site of ERα (C451A-ERα) to obtain membrane-specific loss of function. A complementary mouse lacking the ERα activation function AF-2 (ERα-AF2 0 ) provided selective loss of function of nuclear ERα actions. Physiologic studies revealed critical requirements for membrane receptors in ovarian function and thereby in fertility, and in vascular physiology. In contrast, nuclear ERα actions mediate uterine responses to estrogen and genome-wide analysis indicates that membrane-to-nuclear receptor cross-talk in vivo is quite modest in uterus. These findings demonstrate for the first time critical tissue-specific roles for membrane versus nuclear actions of a steroid hormone receptor in vivo.

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Metadata

Authors
Adlanmerini, M., Solinhac, R., Abot, A., Fabre, A., Raymond-Letron, I., Guihot, A.-L., Boudou, F., Sautier, L., Vessières, E., Kim, S. H., Lière, P., Fontaine, C., Krust, A., Chambon, P., Katzenellenbogen, J. A., Gourdy, P., Shaul, P. W., Henrion, D., Arnal, J.-F., & Lenfant, F.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2013-12-26
Volume
111
Issue
2
Pages
E283-90
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.1322057111
OpenAlex
W2035785296
Cited by
260
References
46
FWCI
14.57
Type
journal article
Language
en
Open access
green

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The paper
Adlanmerini, M., Solinhac, R., Abot, A., Fabre, A., Raymond-Letron, I., Guihot, A.-L., Boudou, F., Sautier, L., Vessières, E., Kim, S. H., Lière, P., Fontaine, C., Krust, A., Chambon, P., Katzenellenbogen, J. A., Gourdy, P., Shaul, P. W., Henrion, D., Arnal, J.-F., & Lenfant, F. (2014). Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1322057111

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.