The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Human breast cancer metastases to the brain display GABAergic properties in the neural niche
Open accessAbstract
Significance: Breast cancer patients typically develop brain metastases years after their initial diagnosis. During this clinical latency, cancer cells must evolve and adapt to the neural microenvironment to colonize. We hypothesized that breast cancer cells may assume brain-like properties to survive in the brain. Our results suggest that metastases overexpress many variables related to the γ-aminobutyric acid (GABA) and were able to proliferate by metabolizing GABA as a biosynthetic energy source. The expression of brain-like properties by breast cancer cells could be a malignant adaptation required for metastasis to the brain, which could potentially be exploited to develop new therapy for breast cancer patients.
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Cites
Comprehensive molecular portraits of human breast tumours
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129
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BackgroundComparing protein abundance and mRNA expression levels on a genomic scale
Greenbaum, D. (2003) · Genome biology · doi:10.1186/gb-2003-4-9-117 · Cited by 1,692
STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury
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Cited by
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,175
Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets
Liang, Y., Zhang, H., Song, X., & Yang, Q. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.08.012 · Cited by 992
Synaptic proximity enables NMDAR signalling to promote brain metastasis
Zeng, Q., Michael, I. P., Zhang, P., Saghafinia, S., Knott, G., Jiao, W., McCabe, B. D., Galván, J. A., Robinson, H. P. C., Zlobec, I., et al. (2019) · Nature · doi:10.1038/s41586-019-1576-6 · Cited by 574
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis
Priego, N., Zhu, L., Monteiro, C., Mulders, M., Wasilewski, D., Bindeman, W., Doglio, L., Martínez, L., Martínez-Saez, E., Ramón y Cajal, S., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0044-4 · Cited by 452
Tumor microenvironment differences between primary tumor and brain metastases
Cacho-Díaz, B., García-Botello, D. R., Wegman-Ostrosky, T., Reyes-Soto, G., Ortiz-Sánchez, E., & Herrera-Montalvo, L. A. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-019-02189-8 · Cited by 310
Metadata
- Authors
- Neman, J., Termini, J., Wilczynski, S., Vaidehi, N., Choy, C., Kowolik, C. M., Li, H., Hambrecht, A. C., Roberts, E., & Jandial, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-01-06
- Volume
- 111
- Issue
- 3
- Pages
- 984-989
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066030073
- Cited by
- 349
- References
- 5
- FWCI
- 16.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Neman, J., Termini, J., Wilczynski, S., Vaidehi, N., Choy, C., Kowolik, C. M., Li, H., Hambrecht, A. C., Roberts, E., & Jandial, R. (2014). Human breast cancer metastases to the brain display GABAergic properties in the neural niche. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1322098111
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