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CD25+CD4+ T cells contribute to the control of memory CD8+ T cells
Open accessAbstract
Previously we demonstrated that IL-15 and IL-2 control the number of memory CD8+ T cells in mice. IL-15 induces, and IL-2 suppresses the division of these cells. Here we show that CD25+CD4+ regulatory T cells play an important role in the IL-2-mediated control of memory phenotype CD8+ T cell number. In animals, the numbers of CD25+CD4+ T cells were inversely correlated with the numbers of memory phenotype CD8+ T cells with age. Treatment with anti-IL-2 caused CD25+CD4+ T cells to disappear and, concurrently, increased the numbers of memory phenotype CD8+ T cells. This increase in the numbers of CD8+ memory phenotype T cells was not manifest in animals lacking CD4+ cells. Importantly, adoptive transfer of CD25+CD4+ T cells significantly reduced division of memory phenotype CD8+ T cells. Thus, we conclude that CD25+CD4+ T cells are involved in the IL-2-mediated inhibition of memory CD8+ T cell division and that IL-2 controls memory phenotype CD8+ T cell numbers at least in part through maintenance of the CD25+CD4+ T cell population.
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Cited by
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Fontenot, J. D., Gavin, M. A., & Rudensky, A. Y. (2003) · Nature Immunology · doi:10.1038/ni904 · Cited by 7,745
Sakaguchi, S. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141122 · Cited by 3,306
Sakaguchi, S. (2005) · Nature Immunology · doi:10.1038/ni1178 · Cited by 2,669
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
Grossman, W. J., Verbsky, J. W., Barchet, W., Colonna, M., Atkinson, J. P., & Ley, T. J. (2004) · Immunity · doi:10.1016/j.immuni.2004.09.002 · Cited by 1,020
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., & Khazaie, K. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408197102 · Cited by 806
Metadata
- Authors
- Murakami, M., Sakamoto, A., Bender, J., Kappler, J., & Marrack, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-06-25
- Volume
- 99
- Issue
- 13
- Pages
- 8832-8837
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2099784945
- Cited by
- 234
- References
- 0
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Murakami, M., Sakamoto, A., Bender, J., Kappler, J., & Marrack, P. (2002). CD25+CD4+ T cells contribute to the control of memory CD8+ T cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.132254399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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