The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
Open accessAbstract
Significance: Chronic granulomatous disease (CGD) has an immunodeficiency component and, in addition, an autoinflammatory component in which autophagy and inflammasome activation are linked and amenable to IL-1 blockade. This study provides a rationale to perform clinical trials to investigate the efficacy of blocking IL-1 in CGD colitis and expands the therapeutic potential of IL-1 antagonists to inflammatory diseases with defective autophagy.
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“Notably, activation of LAP in macrophages also regulates inflammatory signaling pathways (258, 259).”
From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [258]
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Cites
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Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444
Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila
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The Wellcome Trust Case Control Consortium, U.K.
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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
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“Given the suggested role for ROS in autophagy (29, 30), a defective autophagic process responsible for hyperproduction of IL-1β is consistent with NADPH deficiency.”
BackgroundLoss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Saitoh, T., Fujita, N., Jang, M. H., Uematsu, S., Yang, B., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., et al. (2008) · Nature · doi:10.1038/nature07383 · Cited by 2,064
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Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
Dinarello, C. A., Simon, A., & van der Meer, J. W. M. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3800 · Cited by 1,812
Self-citationChronic Granulomatous Disease: Report on a National Registry of 368 Patients
Winkelstein, J. A., Marino, M. C., Johnston, R. B., Boyle, J., Curnutte, J., Gallin, J. I., Malech, H. L., Holland, S. M., Ochs, H., Quie, P., et al. (2000) · Medicine · doi:10.1097/00005792-200005000-00003 · Cited by 1,728
Beyond oxidative stress: an immunologist's guide to reactive oxygen species
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Ouahed, J., Snapper, S. B., Fuss, I. J., & Bousvaros, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11760-2.00040-9
Halawa, M., Gallo, A. L., & Carabetta, V. J. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17111466
van Deuren, R. C., Arts, P., Cavalli, G., Jaeger, M., Steehouwer, M., van de Vorst, M., Gilissen, C., Joosten, L. A. B., Dinarello, C. A., Mhlanga, M. M., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14676614
Self-citationHidradenitis suppurativa as a manifestation of inborn errors of immunity
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Case report: a case of CYBB gene variant in X-linked chronic granulomatous disease
Lv, H. Y., Zhang, J., Zhang, Y., Wei, G., & Chen, Y. (2026) · BMC Pediatrics · doi:10.1186/s12887-026-06749-y
Investigation of intramacrophage stages of Burkholderia cenocepacia using a zebrafish model
Zhang, L. (2016) · theses.fr (ABES) · doi:10.70675/d35cf780z490cz4423z8050zdd2f4021d139
Cold atmospheric plasma stimulates macrophage killing of bacterial pathogens
Blaise, O. (2022) · theses.fr (ABES) · doi:10.70675/8f17afdcz03f2z4d56z8f89z76eb15533502
Advances in Gene Therapy for Chronic Granulomatous Disease
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Thalidomide for CGD-related inflammatory bowel disease: A randomized, double-blind trial
Kawai, T., Sako, M., Arai, K., Ishikawa, T., Toma, T., Wada, T., Yada, Y., Ishimura, M., Doi, T., Okada, S., et al. (2026) · Journal of Human Immunity · doi:10.70962/jhi.20250256
Euler, M., Hattab, O., Slater, K. B., Golub, B., Selin, R. A., Cheng, Z., Villanueva, Y. A. M., Özkan, G. H., Bila, G., Dutta, K., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104302
Itaconate negatively regulates innate immunity during fungal pneumonia
Draper, T. E., Dhruva, P. M., Jones, M., McCarley, R., Bojanowski, C. M., & Steele, C. H. (2026) · mBio · doi:10.1128/mbio.01491-26
Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond
Neehus, A., Sankaran, V. G., Casanova, J., & Bustamante, J. C. (2026) · Journal of Human Immunity · doi:10.70962/jhi.20260106
Metadata
- Authors
- de Luca, A., Smeekens, S. P., Casagrande, A., Iannitti, R., Conway, K. L., Gresnigt, M. S., Begun, J., Plantinga, T. S., Joosten, L. A. B., van der Meer, J. W. M., Chamilos, G., Netea, M. G., Xavier, R. J., Dinarello, C. A., Romani, L., & van de Veerdonk, F. L.
- Affiliations
- Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06122 Perugia, Italy;
- Radboud University Medical Center (NL)
- University of Perugia (IT)
- Harvard University (US)
- Department of Medicine, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands;
- University of Crete (GR)
- Corresponding author
- Dinarello, Charles A.
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-02-18
- Volume
- 111
- Issue
- 9
- Pages
- 3526-3531
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3948220
- OpenAlex
- W2153164696
- Cited by
- 313
- References
- 49
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 10 · 2023: 16 · 2022: 22 · 2021: 32 · 2020: 24 · 2019: 34 · 2018: 26 · 2017: 41 · 2016: 35 · 2015: 26 · 2014: 18
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Crohn's and Colitis Foundation
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI‑15614, AI-62773, R56AI015614, R01AI062773, R01AI015614)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK083756, DK-60049, DK 83756, R01DK097485, DK 43351, R01DK060049, P30DK043351)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- chronic granulomatous disease, IL-1 receptor blockade, anakinra, autophagy, inflammasome activation, IL-1β, NADPH oxidase deficiency, colitis, invasive aspergillosis, macrophages, monocytes, neutrophil recruitment, Th17 response, reactive oxygen species
- MeSH terms
- Animals, Anti-Inflammatory Agents, Aspergillus fumigatus, Autophagy, Colitis, Enzyme-Linked Immunosorbent Assay, Granulomatous Disease, Chronic, Humans, Mice, Inbred C57BL, Mice, Mutant Strains, Microtubule-Associated Proteins, Phagosomes, Receptors, Interleukin-1, Statistics, Nonparametric, NADPH Oxidases, Mice, Interleukin-1beta, Interleukin 1 Receptor Antagonist Protein, Real-Time Polymerase Chain Reaction
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