Gresnigt, Mark S.

A guiding map for inflammation

Netea, M. G., Balkwill, F., Chonchol, M., Cominelli, F., Donath, M. Y., Giamarellos-Bourboulis, E. J., Golenbock, D., Gresnigt, M. S., Heneka, M. T., Hoffman, H. M., et al. (2017) · Nature Immunology

Immune Response and InflammationInflammation biomarkers and pathways

Cited by 831

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

Cheng, S.-C., Scicluna, B. P., Arts, R. J. W., Gresnigt, M. S., Lachmandas, E., Giamarellos-Bourboulis, E. J., Kox, M., Manjeri, G. R., Wagenaars, J. A. L., Cremer, O. L., et al. (2016) · Nature Immunology

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 637

Aspergillus fumigatus morphology and dynamic host interactions

van de Veerdonk, F. L., Gresnigt, M. S., Romani, L., Netea, M. G., & Latgé, J.-P. (2017) · Nature Reviews Microbiology

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 490

IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans

de Luca, A., Smeekens, S. P., Casagrande, A., Iannitti, R., Conway, K. L., Gresnigt, M. S., Begun, J., Plantinga, T. S., Joosten, L. A. B., van der Meer, J. W. M., et al. (2014) · Proceedings of the National Academy of Sciences

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 313

The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes

Kasper, L., König, A., Koenig, P.-A., Gresnigt, M. S., Westman, J., Drummond, R. A., Lionakis, M. S., Groß, O., Ruland, J., Naglik, J. R., et al. (2018) · Nature Communications

Inflammasome and immune disordersAntifungal resistance and susceptibility

Cited by 297

Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

Akoumianaki, T., Kyrmizi, I., Valsecchi, I., Gresnigt, M. S., Samonis, G., Drakos, E., Boumpas, D., Muszkieta, L., Prevost, M.-C., Kontoyiannis, D. P., et al. (2016) · Cell Host & Microbe

Autophagy in Disease and TherapyAntifungal resistance and susceptibility

Cited by 218

Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Smeekens, S. P., Ng, A., Kumar, V., Johnson, M. D., Plantinga, T. S., van Diemen, C., Arts, P., Verwiel, E. T. P., Gresnigt, M. S., Fransen, K., et al. (2013) · Nature Communications

Antifungal resistance and susceptibilityinterferon and immune responses

Cited by 213

Corticosteroids Block Autophagy Protein Recruitment in Aspergillus fumigatus Phagosomes via Targeting Dectin-1/Syk Kinase Signaling

Kyrmizi, I., Gresnigt, M. S., Akoumianaki, T., Samonis, G., Sidiropoulos, P., Boumpas, D., Netea, M. G., van de Veerdonk, F. L., Kontoyiannis, D. P., & Chamilos, G. (2013) · The Journal of Immunology

Antifungal resistance and susceptibilityAutophagy in Disease and Therapy

Cited by 142

A Polysaccharide Virulence Factor from Aspergillus fumigatus Elicits Anti-inflammatory Effects through Induction of Interleukin-1 Receptor Antagonist

Gresnigt, M. S., Bozza, S., Becker, K. L., Joosten, L. A. B., Abdollahi-Roodsaz, S., van der Berg, W. B., Dinarello, C. A., Netea, M. G., Fontaine, T., De Luca, A., et al. (2014) · PLoS Pathogens

Antifungal resistance and susceptibilityFungal and yeast genetics research

Cited by 142

Immunotherapeutic approaches to treatment of fungal diseases

Armstrong-James, D., Brown, G. D., Netea, M. G., Zelante, T., Gresnigt, M. S., van de Veerdonk, F. L., & Levitz, S. M. (2017) · The Lancet Infectious Diseases

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 135

Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells

Pekmezovic, M., Hovhannisyan, H., Gresnigt, M. S., Iracane, E., Oliveira-Pacheco, J., Siscar-Lewin, S., Seemann, E., Qualmann, B., Kalkreuter, T., Müller, S., et al. (2021) · Nature Microbiology

Antifungal resistance and susceptibilityinterferon and immune responses

Cited by 96

Pattern recognition pathways leading to a Th2 cytokine bias in allergic bronchopulmonary aspergillosis patients

Becker, K. L., Gresnigt, M. S., Smeekens, S. P., Jacobs, C. W., Magis‐Escurra, C., Jaeger, M., Wang, X., Lubbers, R., Oosting, M., Joosten, L. A. B., et al. (2015) · Clinical & Experimental Allergy

Asthma and respiratory diseasesAntifungal resistance and susceptibility

Cited by 83

Keeping Candida commensal: how lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model

Graf, K., Last, A., Gratz, R., Allert, S., Linde, S., Westermann, M., Gröger, M., Mosig, A. S., Gresnigt, M. S., & Hube, B. (2019) · Disease Models & Mechanisms

Antifungal resistance and susceptibilityProbiotics and Fermented Foods

Cited by 83

Aspergillus Cell Wall Chitin Induces Anti- and Proinflammatory Cytokines in Human PBMCs via the Fc-γ Receptor/Syk/PI3K Pathway

Becker, K. L., Aimanianda, V., Wang, X., Gresnigt, M. S., Ammerdorffer, A., Jacobs, C. W., Gazendam, R. P., Joosten, L. A. B., Netea, M. G., Latgé, J. P., et al. (2016) · mBio

Studies on Chitinases and ChitosanasesImmune Response and Inflammation

Cited by 73

The Multifaceted Role of T-Helper Responses in Host Defense against Aspergillus fumigatus

Dewi, I., Van de Veerdonk, F., & Gresnigt, M. (2017) · Journal of Fungi

Antifungal resistance and susceptibilityAsthma and respiratory diseases

Cited by 69

I want to break free – macrophage strategies to recognize and kill Candida albicans, and fungal counter-strategies to escape

Austermeier, S., Kasper, L., Westman, J., & Gresnigt, M. S. (2020) · Current Opinion in Microbiology

Antifungal resistance and susceptibilityFungal Infections and Studies

Cited by 55

Low Interleukin-17A Production in Response to Fungal Pathogens in Patients with Chronic Granulomatous Disease

Smeekens, S. P., Henriet, S. S. V., Gresnigt, M. S., Joosten, L. A. B., Hermans, P. W. M., Netea, M. G., Warris, A., & van de Veerdonk, F. L. (2012) · Journal of Interferon & Cytokine Research

Neutrophil, Myeloperoxidase and Oxidative MechanismsImmunodeficiency and Autoimmune Disorders

Cited by 20

Toll-like receptor 2 induced cytotoxic T-lymphocyte-associated protein 4 regulates Aspergillus-induced regulatory T-cells with pro-inflammatory characteristics

Raijmakers, R. P. H., Sprenkeler, E. G. G., Aleva, F. E., Jacobs, C. W. M., Kanneganti, T.-D., Joosten, L. A. B., van de Veerdonk, F. L., & Gresnigt, M. S. (2017) · Scientific Reports

T-cell and B-cell ImmunologyAsthma and respiratory diseases

Cited by 16

Type I interferons during host–fungus interactions: Is antifungal immunity going viral?

Pekmezovic, M., Dietschmann, A., & Gresnigt, M. S. (2022) · PLOS Pathogens

interferon and immune responsesAntifungal resistance and susceptibility

Cited by 12