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UNC93B1 is essential for the plasma membrane localization and signaling of Toll-like receptor 5
Abstract
Significance: Toll-like receptors (TLRs) are key innate immune receptors that sense pathogen- or danger-associated molecules. The members of the TLR family can be classified into two groups based on their subcellular localization patterns—cell surface vs. endolysosomes—but how individual TLR is targeted to its destination is largely unknown. UNC93B1 was regarded to specifically bind the endolysosomal TLRs in the endoplasmic reticulum and deliver them to endolysosomes with no role for the surface-localized TLRs. In this study, we demonstrate that TLR5, a cell surface receptor for bacterial protein flagellin, also binds UNC93B1 and requires it for plasma membrane localization and signaling, thus revealing a previously unappreciated role of UNC93B1 in the regulation of the TLR family.
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“However, requirement of UNC93B1 is not restricted to NA-sensing endosomal TLRs, as it is also key to cell-surface expression of the flagellin-sensing TLR5 (12).”
From UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b (2021) · cites this paper as [12]
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Nucleic acid‐sensing TLR s and autoimmunity: novel insights from structural and cell biology
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Metadata
- Authors
- Huh, J.-W., Shibata, T., Hwang, M., Kwon, E.-H., Jang, M. S., Fukui, R., Kanno, A., Jung, D.-J., Jang, M. H., Miyake, K., & Kim, Y.-M.
- Affiliations
- Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea;
- Division of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-04-28
- Volume
- 111
- Issue
- 19
- Pages
- 7072-7077
- ISSN
- 0027-8424
- 1091-6490
- Cited by
- 65
- References
- 1
- Language
- en
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