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The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
Abstract
Toll-like receptors (TLRs) sense the presence of microbial and viral pathogens by signal transduction mechanisms that remain to be fully elucidated. A single point mutation (H412R) in the polytopic endoplasmic reticulum (ER)–resident membrane protein UNC93B abolishes signaling via TLR3, 7, and 9. We show that UNC93B specifically interacts with TLR3, 7, 9, and 13, whereas introduction of the point mutation H412R in UNC93B abolishes their interactions. We establish the physical interaction of the intracellular TLRs with UNC93B in splenocytes and bone marrow–derived dendritic cells. Further, by expressing chimeric TLRs, we show that TLR3 and 9 bind to UNC93B via their transmembrane domains. We propose that a physical association between UNC93B and TLRs in the ER is essential for proper TLR signaling.
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UNC93B1 deficiency does not affect TLR7 expression.
“However, analyzing UNC93B1-deficient dendritic cells Brinkmann et al. had previously demonstrated that UNC93B1 deficiency does not affect TLR7 expression (10).”
From UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b (2021) · cites this paper as [10]
UNC93B1 binds to TLR3, TLR7, and TLR9 in the ER and traffics with them to their appropriate intracellular locations.
“In particular, this chaperone binds to TLR3, TLR7, and TLR9 in the ER and traffics with them to their appropriate intracellular locations where they are subsequently available to sense their cognate ligands (9, 10).”
From UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b (2021) · cites this paper as [10]
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Cites
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 2×
“…the Gram-negative bacterial outer membrane, whereas doublestranded RNA, single-stranded RNA, and unmethylated bacterial DNA (CpG) engage TLR3, 7, and 9, respectively (Poltorak et al., 1998; Hemmi et al., 2000; Alexopoulou et al., 2001; Bauer et al., 2001; Diebold et al., 2004; Heil et al., 2004).”
BackgroundRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Flagged first, then by citations
Research works printed but not linked: 41
- 2005, Nat. Immunol., 6, 107, 10.1038/ni1147 · DOI
- 2006, Immunity., 25, 607, 10.1016/j.immuni.2006.08.017 · DOI
- 2002, Eur. J. Immunol., 32, 1958, 10.1002/1521-4141(200207)32:7<1958::AID-IMMU1958>3.0.CO;2-U · DOI
- 2006, Nat. Immunol., 7, 49, 10.1038/ni1280 · DOI
- 2001, Proc. Natl. Acad. Sci. USA., 98, 9237, 10.1073/pnas.161293498 · DOI
- 2006, Annu. Rev. Immunol., 24, 353, 10.1146/annurev.immunol.24.021605.090552 · DOI
- 2006, Science., 314, 308, 10.1126/science.1128346 · DOI · Paper page
- 2003, Curr. Opin. Struct. Biol., 13, 412, 10.1016/S0959-440X(03)00102-7 · DOI
- 2003, J. Neurosci., 23, 9133, 10.1523/JNEUROSCI.23-27-09133.2003 · DOI
- 2004, Int. Immunol., 16, 1143, 10.1093/intimm/dxh115 · DOI
- 1980, Genetics., 96, 147, 10.1093/genetics/96.1.147 · DOI
- 2004, Science., 303, 1526, 10.1126/science.1093620 · DOI · Paper page
- 2002, Nat. Immunol., 3, 196, 10.1038/ni758 · DOI
- 2003, Nature., 424, 743, 10.1038/nature01889 · DOI
- 2006, Nature., 440, 949, 10.1038/nature04641 · DOI
- 2005, Int. Immunol., 17, 45, 10.1093/intimm/dxh184 · DOI
- 2004, Nat. Immunol., 5, 987, 10.1038/ni1112 · DOI
- 2006, Biochem. Biophys. Res. Commun., 343, 578, 10.1016/j.bbrc.2006.03.014 · DOI
- 2002, Gene., 283, 209, 10.1016/S0378-1119(01)00856-3 · DOI
- 2006, Cell Death Differ., 13, 816, 10.1038/sj.cdd.4401850 · DOI
- 1999, Immunity., 11, 115, 10.1016/S1074-7613(00)80086-2 · DOI
- 2004, Nat. Immunol., 5, 190, 10.1038/ni1028 · DOI
- 2004, J. Immunol., 173, 1179, 10.4049/jimmunol.173.2.1179 · DOI
- 1992, J. Cell Biol., 117, 143, 10.1083/jcb.117.1.143 · DOI
- 2004, Nature., 429, 834, 10.1038/nature02592 · DOI
- 2002, BMC Genet., 3, 20
- 2005, J. Immunol., 174, 7066, 10.4049/jimmunol.174.11.7066 · DOI
- 2003, J. Immunol., 171, 3154, 10.4049/jimmunol.171.6.3154 · DOI
- 2002, Nat. Immunol., 3, 667, 10.1038/ni809 · DOI
- 2004, J. Biol. Chem., 279, 19008, 10.1074/jbc.M311618200 · DOI
- 2005, J. Biol. Chem., 280, 37107, 10.1074/jbc.M504951200 · DOI
- 2004, Proteins., 54, 648, 10.1002/prot.10611 · DOI
- 1998, Science., 282, 2085, 10.1126/science.282.5396.2085 · DOI · Paper page
- 2001, Nat. Cell Biol., 3, 891, 10.1038/ncb1001-891 · DOI · Paper page
- 2005, Genes Dev., 19, 2668, 10.1101/gad.1360605 · DOI
- 1999, J. Exp. Med., 189, 1777, 10.1084/jem.189.11.1777 · DOI
- 2006, Virol. J., 3, 26, 10.1186/1743-422X-3-26 · DOI
- 2002, Nature., 416, 750, 10.1038/nature736 · DOI
- 2004, Proc. Natl. Acad. Sci. USA., 101, 3516, 10.1073/pnas.0400525101 · DOI
- 2006, Nat. Immunol., 7, 156
- 2003, Annu. Rev. Immunol., 21, 335, 10.1146/annurev.immunol.21.120601.141126 · DOI · Paper page
Cited by
Sorted by citations
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity
Kawai, T., & Akira, S. (2011) · Immunity · doi:10.1016/j.immuni.2011.05.006 · Cited by 3,658
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
Nucleic acid recognition by the innate immune system
Barbalat, R., Ewald, S. E., Mouchess, M. L., & Barton, G. M. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101340 · Cited by 577
TLR13 Recognizes Bacterial 23 S rRNA Devoid of Erythromycin Resistance–Forming Modification
Oldenburg, M., Krüger, A., Ferstl, R., Kaufmann, A., Nees, G., Sigmund, A., Bathke, B., Lauterbach, H., Suter, M., Dreher, S., et al. (2012) · Science · doi:10.1126/science.1220363 · Cited by 405
Henault, J., Martinez, J., Riggs, J. M., Tian, J., Mehta, P., Clarke, L., Sasai, M., Latz, E., Brinkmann, M. M., Iwasaki, A., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.014 · Cited by 348
Self-citationInterferons: Signaling, antiviral and viral evasion
Bonjardim, C. A., Ferreira, P. C. P., & Kroon, E. G. (2009) · Immunology Letters · doi:10.1016/j.imlet.2008.11.002 · Cited by 196
Cotrafficking of SV2 and synaptotagmin at the synapse
Yao, J., Nowack, A., Kensel-Hammes, P., Gardner, R. G., & Bajjalieh, S. M. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4781-09.2010 · Cited by 164
Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses
Huang, X., & Yang, Y. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501333 · Cited by 121
Nucleic acid‐sensing TLR s and autoimmunity: novel insights from structural and cell biology
Pelka, K., Shibata, T., Miyake, K., & Latz, E. (2016) · Immunological Reviews · doi:10.1111/imr.12375 · Cited by 110
RNA Mediated toll-like receptor stimulation in health and disease
Dalpke, A. H., & Helm, M. (2012) · RNA Biology · doi:10.4161/rna.20206 · Cited by 113
Maatouk, L., Compagnion, A.-C., Sauvage, M.-A. C.-D., Bemelmans, A.-P., Leclere-Turbant, S., Cirotteau, V., Tohme, M., Beke, A., Trichet, M., Bazin, V., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04569-y · Cited by 95
Klammer, M. G., Dzaye, O., Wallach, T., Krüger, C., Gaessler, D., Buonfiglioli, A., Derkow, K., Kettenmann, H., Brinkmann, M. M., & Lehnardt, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.715774 · Cited by 6
Self-citation
Metadata
- Authors
- Brinkmann, M. M., Spooner, E., Hoebe, K., Beutler, B., Ploegh, H. L., & Kim, Y.-M.
- Affiliations
- 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142
- 2Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037
- Venue
- The Journal of Cell Biology
- Publisher
- Rockefeller University Press
- Published
- 2007-04-23
- Volume
- 177
- Issue
- 2
- Pages
- 265-275
- ISSN
- 1540-8140
- 0021-9525
- PMC
- PMC2064135
- Cited by
- 411
- References
- 5
- Language
- en
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