The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation
Open accessAbstract
Significance: Plant cell walls are recalcitrant copolymeric structures mainly comprising polysaccharides and lignin. Enzymatic degradation of the polysaccharides is a crucial step in biorefining of biomass. Recently, it was discovered that nature employs copper-dependent redox enzymes called lytic polysaccharide monoxoygenases (LPMOs) to promote degradation of the most recalcitrant and crystalline of these polysaccharides, cellulose. By carrying out oxidative cleavage of otherwise inaccessible cellulose chains, LPMOs create access points for classical hydrolytic enzymes such as cellulases. Intriguingly, the genomes of biomass degrading microorganisms encode a plethora of LPMOs (up to over 40). To our knowledge, we demonstrate for the first time that LPMOs act on hemicelluloses. This finding dramatically widens the scope of LPMOs and oxidative processes in plant cell wall degradation and biorefining.
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Cites
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Self-citationToward a Systems Approach to Understanding Plant Cell Walls
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Payne, C. M., Knott, B. C., Mayes, H. B., Hansson, H., Himmel, M. E., Sandgren, M., Ståhlberg, J., & Beckham, G. T. (2015) · Chemical Reviews · doi:10.1021/cr500351c · Cited by 855
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Self-citationOxidative cleavage of polysaccharides by monocopper enzymes depends on H2O2
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Self-citationA review on commercial-scale high-value products that can be produced alongside cellulosic ethanol
Rosales-Calderon, O., & Arantes, V. (2019) · Biotechnology for Biofuels · doi:10.1186/s13068-019-1529-1 · Cited by 503
Metadata
- Authors
- Agger, J. W., Isaksen, T., Várnai, A., Vidal-Melgosa, S., Willats, W. G. T., Ludwig, R., Horn, S. J., Eijsink, V. G. H., & Westereng, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-04-14
- Volume
- 111
- Issue
- 17
- Pages
- 6287-6292
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2106706785
- Cited by
- 425
- References
- 35
- FWCI
- 22.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Agger, J. W., Isaksen, T., Várnai, A., Vidal-Melgosa, S., Willats, W. G. T., Ludwig, R., Horn, S. J., Eijsink, V. G. H., & Westereng, B. (2014). Discovery of LPMO activity on hemicelluloses shows the importance of oxidative processes in plant cell wall degradation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1323629111
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