Reproducible selection of high avidity CD8 + T-cell clones following secondary acute virus infection
Open accessAbstract
Significance: Exactly how memory cells are selected into a recall response to acute viral infection (stochastic or deterministic) remains unresolved. This paper demonstrates definitively that selection of virus-specific CD8 + T cells from memory occurs via active selection of particular T-cell clones after secondary virus infection and that this selection appears to be based on the avidity of the T-cell receptor (TCR) for the virus-derived peptide (p) + major histocompatibility complex class I molecule. We also show that despite clear clonal preferences, there is no global narrowing of epitope-specific TCR diversity in the recall response. We propose that the immune system has evolved such a strategy to optimize cytotoxic T-lymphocyte responses while safeguarding TCR repertoire diversity.
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Recall responses in mice did not cause contraction of peptide-specific responses.
“Recall responses in mice did not cause a contraction of the peptide-specific responses”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Cukalac et al., 2014
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- Authors
- Cukalac, T., Chadderton, J., Handel, A., Doherty, P. C., Turner, S. J., Thomas, P. G., & La Gruta, N. L.
- Affiliations
- The University of Melbourne (AU)
- University of Georgia (US)
- St. Jude Children's Research Hospital (US)
- Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Parkville, VIC 3010, Australia;
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-01-13
- Volume
- 111
- Issue
- 4
- Pages
- 1485-1490
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3910643
- OpenAlex
- W2089098331
- Cited by
- 39
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 5 · 2019: 3 · 2018: 7 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 1
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI107625, AI091938, R01AI107625, R56AI091938)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- CD8+ T cells, cytotoxic T lymphocytes, T cell receptor avidity, clonal selection, clonal expansion, T cell receptor diversity, adoptive transfer, TCR clonotypes
- MeSH terms
- Amino Acid Sequence, Animals, Antibody Affinity, Clone Cells, Female, Humans, Immunologic Memory, Mice, Inbred C57BL, Molecular Sequence Data, Orthomyxoviridae Infections, Reproducibility of Results, Immunophenotyping, Receptors, Antigen, T-Cell, alpha-beta, CD8-Positive T-Lymphocytes
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