T cell receptor αβ diversity inversely correlates with pathogen-specific antibody levels in human cytomegalovirus infection
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CD8 + T cell diversity may be more important than T cell abundance in limiting the negative consequences of cytomegalovirus persistence.
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Repertoire studies of CMV-specific T cells provide evidence that TCR breadth of the peptide-specific response is functionally important.
“Repertoire studies of CMV-specific T cells provided evidence that TCR breadth of the peptide-specific response is functionally important”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Wang et al., 2012
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- Authors
- Wang, G. C., Dash, P., McCullers, J. A., Doherty, P. C., & Thomas, P. G.
- Affiliations
- St. Jude Children's Research Hospital (US)
- Johns Hopkins University (US)
- Corresponding author
- Wang, George C.
- Thomas, Paul G.
- Venue
- Science Translational Medicine
- Published
- 2012-04-04
- Volume
- 4
- Issue
- 128
- Pages
- 128ra42-128ra42
- ISSN
- 1946-6234 (ISSN-L)
- 1946-6242
- PMC
- PMC3593633
- OpenAlex
- W2171373682
- Cited by
- 238
- References
- 52
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 11 · 2023: 14 · 2022: 10 · 2021: 23 · 2020: 17 · 2019: 27 · 2018: 19 · 2017: 28 · 2016: 21 · 2015: 13 · 2014: 19 · 2013: 13 · 2012: 1
- FWCI
- 6.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science Translational Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG021334, AG033113, K23AG033113, P30AG021334)
- National Institute of Allergy and Infectious Diseases (R01AI070251, K22AI077714, AI077714, AI 70251)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Cell Function and Interaction
- Keywords
- TCR diversity, CD8+ T cells, human cytomegalovirus infection, CMV viral load, T cell clonotypes, T cell immunity, immunotherapy targets
- MeSH terms
- Adult, Aged, Aged, 80 and over, Antibodies, Viral, Cytomegalovirus Infections, Female, Humans, Male, Receptors, Antigen, T-Cell, alpha-beta, CD8-Positive T-Lymphocytes, Viral Load, Young Adult
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