The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5
Open accessAbstract
Significance: Many cancer-associated variants have been found in the 8q24.21 region harboring enhancer activity. However, the functional mechanism of the variants is not clear due to the lack of protein-coding genes in the region and no significant correlation with the nearest oncogene MYC . We identified long noncoding RNAs (lncRNAs) named cancer-associated region long noncoding RNAs ( CARLo s) in the 8q24.21 region. Interestingly, we found that the cancer-associated variant rs6983267 regulating the enhancer activity is significantly associated with the expression of one of the lncRNAs CARLo-5 and that CARLo-5 has an oncogenic function. By showing direct interaction between the enhancer region and active regulatory region of the CARLo-5 promoter, we provide a regulatory mechanism of cancer susceptibility caused by the cancer-associated variants.
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Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
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Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24
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Quantitative analysis of chromosome conformation capture assays (3C-qPCR)
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“The 3C library preparation from HCT116 and RKO cells was performed as described before (25).”
MethodThe 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer
Pomerantz, M. M., Ahmadiyeh, N., Jia, L., Herman, P., Verzi, M. P., Doddapaneni, H., Beckwith, C. A., Chan, J. A., Hills, A., Davis, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.403 · Cited by 663
Cited by
Gene regulation by long non-coding RNAs and its biological functions
Statello, L., Guo, C.-J., Chen, L.-L., & Huarte, M. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00315-9 · Cited by 4,991
The emerging role of lncRNAs in cancer
Huarte, M. (2015) · Nature Medicine · doi:10.1038/nm.3981 · Cited by 2,702
The role of non-coding RNAs in oncology
Slack, F. J., & Chinnaiyan, A. M. (2019) · Cell · doi:10.1016/j.cell.2019.10.017 · Cited by 1,619
Colorectal Carcinoma: A General Overview and Future Perspectives in Colorectal Cancer
Mármol, I., Sánchez-de-Diego, C., Pradilla Dieste, A., Cerrada, E., & Rodriguez Yoldi, M. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18010197 · Cited by 1,525
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Bartonicek, N., Maag, J. L. V., & Dinger, M. E. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0530-6 · Cited by 459
Metadata
- Authors
- Kim, T., Cui, R., Jeon, Y.-J., Lee, J.-H., Lee, J. H., Sim, H., Park, J. K., Fadda, P., Tili, E., Nakanishi, H., Huh, M.-I., Kim, S.-H., Cho, J. H., Sung, B. H., Peng, Y., Lee, T. J., Luo, Z., Sun, H.-L., Wei, H., Alder, H., Oh, J. S., Shim, K. S., Ko, S.-B., & Croce, C. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-04
- Volume
- 111
- Issue
- 11
- Pages
- 4173-4178
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2117621143
- Cited by
- 186
- References
- 6
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, T., Cui, R., Jeon, Y.-J., Lee, J.-H., Lee, J. H., Sim, H., Park, J. K., Fadda, P., Tili, E., Nakanishi, H., Huh, M.-I., Kim, S.-H., Cho, J. H., Sung, B. H., Peng, Y., Lee, T. J., Luo, Z., Sun, H.-L., Wei, H., . . . Croce, C. M. (2014). Long-range interaction and correlation between MYC enhancer and oncogenic long noncoding RNA CARLo-5. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1400350111
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