The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo
Open accessAbstract
Significance: Centrioles form the core of centrosomes, which organize cilia and interphase and spindle microtubules in animal cells, but centrosome function has not been defined in mammals in vivo. We show that mouse embryos that lack centrioles and centrosomes survive to midgestation, when they lack primary cilia and cilia-dependent signaling. Despite the absence of centrosomes, bipolar spindle formation, chromosome segregation, cell-cycle profile, and DNA damage response are normal in the mutants. Unlike mutants that lack cilia, most cells in acentriolar embryos activate a p53-dependent apoptotic pathway. The data show that mammalian centrioles promote the efficient and rapid assembly of the mitotic spindle and that a short delay in prometaphase activates a checkpoint that leads to p53-dependent cell death in vivo.
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The primary cilium: a signalling centre during vertebrate development
Goetz, S. C., & Anderson, K. V. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2774 · Cited by 1,824
Self-citationAltered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Simons, M., Gloy, J., Ganner, A., Bullerkotte, A., Bashkurov, M., Krönig, C., Schermer, B., Benzing, T., Cabello, O. A., Jenny, A., et al. (2005) · Nature Genetics · doi:10.1038/ng1552 · Cited by 767
Kif3a constrains β-catenin-dependent Wnt signalling through dual ciliary and non-ciliary mechanisms
Corbit, K. C., Shyer, A. E., Dowdle, W. E., Gaulden, J., Singla, V., & Reiter, J. F. (2008) · Nature Cell Biology · doi:10.1038/ncb1670 · Cited by 509
Subcellular spatial regulation of canonical Wnt signalling at the primary cilium
Lancaster, M. A., Schroth, J., & Gleeson, J. G. (2011) · Nature Cell Biology · doi:10.1038/ncb2259 · Cited by 267
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Liem, K. F., Ashe, A., He, M., Satir, P., Moran, J., Beier, D., Wicking, C., & Anderson, K. V. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201110049 · Cited by 214
Self-citationMigeotte, I., Omelchenko, T., Hall, A., & Anderson, K. V. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000442 · Cited by 114
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Cited by
Primary Cilia and Mammalian Hedgehog Signaling
Bangs, F., & Anderson, K. V. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028175 · Cited by 642
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Metadata
- Authors
- Bazzi, H., & Anderson, K. V.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-03-31
- Volume
- 111
- Issue
- 15
- Pages
- E1491-500
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078873544
- Cited by
- 194
- References
- 8
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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