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Bacterial fight-and-flight responses enhance virulence in a polymicrobial infection
Open accessAbstract
Significance: Polymicrobial synergy occurs when infections caused by more than one species are more severe than the sum of the individual species acting alone. Here, we show that a bacterial fight-and-flight response to an antimicrobial, hydrogen peroxide (H 2 O 2 ), is required for a pathogen to display synergy with a commensal bacterium in vivo. H 2 O 2 is generated by the commensal, and in response, the pathogen either enzymatically destroys (fights) the antimicrobial or disperses away (takes flight) from the antimicrobial-producing commensal. Remarkably, both behaviors are critical for the pathogen to display synergy during coinfection. Moreover, when the pathogen is unable to disperse, the community loses spatial organization, trapping the pathogen next to the commensal.
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“When co-cultured with S. gordonii, A. actinomycetemcomitans cells upregulated the dspB gene encoding the poly-N-acetyl-d-glucosamine–degrading enzyme Dispersin B.81”
From The dental plaque biofilm matrix (2021) · cites this paper as [81]
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“The matrix helps to position cells at a distance where mutually beneficial interactions are optimized and competition is minimized.81,230”
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Metadata
- Authors
- Stacy, A., Everett, J., Jorth, P., Trivedi, U., Rumbaugh, K. P., & Whiteley, M.
- Affiliations
- The University of Texas at Austin (US)
- Texas Tech University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2014-05-13
- Volume
- 111
- Issue
- 21
- Pages
- 7819-7824
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4040543
- OpenAlex
- W2088151791
- Cited by
- 192
- References
- 58
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 22 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 20 · 2018: 12 · 2017: 21 · 2016: 18 · 2015: 15 · 2014: 7
- FWCI
- 8.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE020100)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Aggregatibacter actinomycetemcomitans, Streptococcus gordonii, co-infection, cross-feeding, hydrogen peroxide, dispersin B, biofilm dispersal, fight-or-flight response, oral infection, virulence
- MeSH terms
- Animals, Bacterial Proteins, Catalase, Glycoside Hydrolases, Hydrogen Peroxide, Virulence, Aggregatibacter actinomycetemcomitans, Biofilms, Lactic Acid, Microarray Analysis, Mice, Streptococcus gordonii, Coinfection
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