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Cited by 221

Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers

Akat, Kemal Marc, Moore-McGriff, D’Vesharronne, Morozov, Pavel, Brown, Miguel, Gogakos, Tasos, Correa Da Rosa, Joel, Mihailovic, Aleksandra, Sauer, Markus +6 more·2014·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1401724111
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Abstract

Significance: Heart failure (HF) has a high morbidity and mortality and its incidence is increasing worldwide. While protein biomarkers have been established for diagnostic and prognostic evaluation of patients with HF, there is currently no systematic assessment of RNA biomarkers. We determined the composition of myocardial tissue and circulating microRNAs (miRNAs) in a large cohort of patients with stable and advanced HF and compared it to the composition of normal adult and fetal samples. The advanced HF patients underwent mechanical unloading with left ventricular assist devices and samples were collected at different postoperative time points. Our findings provide the underpinning for miRNA-based therapies and emphasize the usefulness of circulating miRNAs as biomarkers for heart injury performing similar to established diagnostic protein biomarkers.

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  • Elevated levels of circulating myomiRs (miR-1, miR-206 and miR-133a/b) have been proposed as biomarkers for heart failure and different forms of muscle dystrophy, but are also elevated after half-marathon run (27-29).

    “Elevated levels of circulating myomiRs, i.e. miR-1, miR-206 and miR-133a/b, have been proposed as biomarker for heart failure and different forms of muscle dystrophy, but are also elevated after half-marathon run (27–29).”

    From Distribution of miRNA expression across human tissues (2016) · cites this paper as [27]

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Research works printed but not linked: 17

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Authors
Akat, K. M., Moore-McGriff, D., Morozov, P., Brown, M., Gogakos, T., Correa Da Rosa, J., Mihailovic, A., Sauer, M., Ji, R., Ramarathnam, A., Totary-Jain, H., Williams, Z., Tuschl, T., & Schulze, P. C.
Affiliations
  • Laboratory of RNA Molecular Biology,
  • Division of Cardiology, Department of Medicine, Columbia University Medical Center, New York, NY 10032;
  • the Center for Clinical and Translational Science, and
  • Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL 33612; and
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2014-07-10
Volume
111
Issue
30
Pages
11151-11156
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1401724111
Cited by
221
References
3
Language
en

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