The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death
Open accessAbstract
Significance: Receptor-interacting protein-1 (RIP1) kinase and caspase-8 are important players in activation of apoptotic pathways. Here we show that RIP1, caspase-8, and RIP3 contribute to infection-induced macrophage cell death and also are required for activation of transcription factor NF-κB and caspase-1 upon infection with the bacterial pathogen Yersinia pestis , the causative agent of plague. Mice lacking caspase-8 and RIP3 are also very susceptible to bacterial infection. This suggests that RIP1, caspase-8, and RIP3 are key molecules with multiple roles in innate immunity during bacterial challenge.
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Cites
Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435
Self-citationRIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · cited 1×
“These data indicate a vital role for caspase-8 in suppressing necroptosis by targeting a component of the RIP3 pathway (8, 9).”
BackgroundRIP3 mediates the embryonic lethality of caspase-8-deficient mice
Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057
Self-citationToll-like Receptor 3-mediated Necrosis via TRIF, RIP3, and MLKL
Kaiser, W. J., Sridharan, H., Huang, C., Mandal, P., Upton, J. W., Gough, P. J., Sehon, C. A., Marquis, R. W., Bertin, J., & Mocarski, E. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.462341 · Cited by 959
Self-citationInhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation
Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.012 · Cited by 491
Cited by
Necroptosis and its role in inflammation
Pasparakis, M., & Vandenabeele, P. (2015) · Nature · doi:10.1038/nature14191 · Cited by 2,148
Necroptosis in development, inflammation and disease
Weinlich, R., Oberst, A., Beere, H. M., & Green, D. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.149 · Cited by 1,016
Samir, P., Malireddi, R. K. S., & Kanneganti, T.-D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00238 · Cited by 557
RIPK1 Distinctly Regulates Yersinia-Induced Inflammatory Cell Death, PANoptosis
Malireddi, R. K. S., Kesavardhana, S., Karki, R., Kancharana, B., Burton, A. R., & Kanneganti, T.-D. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000097 · Cited by 224
Cho, M., Dho, S. H., Shin, S., Lee, Y., Kim, Y., Lee, J., Yu, S. J., Park, S. H., Lee, K.-A., & Kim, L. K. (2022) · Journal of Autoimmunity · doi:10.1016/j.jaut.2022.102940 · Cited by 18
Metadata
- Authors
- Weng, D., Marty-Roix, R., Ganesan, S., Proulx, M. K., Vladimer, G. I., Kaiser, W. J., Mocarski, E. S., Pouliot, K., Chan, F. K.-M., Kelliher, M. A., Harris, P. A., Bertin, J., Gough, P. J., Shayakhmetov, D. M., Goguen, J. D., Fitzgerald, K. A., Silverman, N., & Lien, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-05-05
- Volume
- 111
- Issue
- 20
- Pages
- 7391-7396
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2032897380
- Cited by
- 298
- References
- 6
- FWCI
- 11.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Weng, D., Marty-Roix, R., Ganesan, S., Proulx, M. K., Vladimer, G. I., Kaiser, W. J., Mocarski, E. S., Pouliot, K., Chan, F. K.-M., Kelliher, M. A., Harris, P. A., Bertin, J., Gough, P. J., Shayakhmetov, D. M., Goguen, J. D., Fitzgerald, K. A., Silverman, N., & Lien, E. (2014). Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1403477111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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