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Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy
Open accessAbstract
Significance: Drug-releasing polymers give clinicians the ability to deliver chemotherapy directly to tumors, sparing the rest of the body from toxic side effects. Most devices deliver a constant, unchangeable drug dose over time. However, we found that cancer cells are more sensitive to short-term, high-dose “bursts” of the chemotherapeutic mitoxantrone than to constant doses over longer periods, suggesting a benefit for implantable devices that allow external control over dose and timing. Biocompatible, injectable alginate hydrogels displayed the ability to self-heal damage induced by ultrasound pulses, enabling on-demand delivery of mitoxantrone, in vitro and in vivo, and mitoxantrone-loaded gels implanted near tumors were more effective at eliminating tumor growth when a daily pulse of ultrasound was applied.
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Citations
Cited by
Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 4,832
Self-citationSelf-Healing Injectable Hydrogels for Tissue Regeneration
Bertsch, P., Diba, M., Mooney, D. J., & Leeuwenburgh, S. C. G. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00179 · Cited by 892
Self-citationAdvances in Biomaterials for Drug Delivery
Fenton, O. S., Olafson, K. N., Pillai, P. S., Mitchell, M. J., & Langer, R. (2018) · Advanced Materials · doi:10.1002/adma.201705328 · Cited by 855
Rizwan, M., Yahya, R., Hassan, A., Yar, M., Azzahari, A., Selvanathan, V., Sonsudin, F., & Abouloula, C. (2017) · Polymers · doi:10.3390/polym9040137 · Cited by 844
Lu, P., Ruan, D., Huang, M., Tian, M., Zhu, K., Gan, Z., & Xiao, Z. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01852-x · Cited by 667
Metadata
- Authors
- Huebsch, N., Kearney, C. J., Zhao, X., Kim, J., Cezar, C. A., Suo, Z., & Mooney, D. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-06-24
- Volume
- 111
- Issue
- 27
- Pages
- 9762-9767
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2116351792
- Cited by
- 453
- References
- 0
- FWCI
- 14.04
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Huebsch, N., Kearney, C. J., Zhao, X., Kim, J., Cezar, C. A., Suo, Z., & Mooney, D. J. (2014). Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1405469111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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