The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Immature truncated O-glycophenotype of cancer directly induces oncogenic features
Open accessAbstract
Significance: Cancer cells characteristically express proteins with immature O-glycosylation, but how and why cancer cells express immature O-glycans has remained poorly understood. Here, we report that one prevalent mechanism in pancreatic cancer is epigenetic silencing, rather than somatic mutations in a key chaperone, core 1 β3-Gal-T-specific molecular chaperone (COSMC), required for mature elongated O-glycosylation. We also demonstrate, with the use of well-defined cell systems generated by precise gene editing, that the aberrant O-glycophenotype by itself induces oncogenic features with enhanced growth and invasion. Our study suggests that the characteristic aberrant O-glycophenotype is critical for the development and behavior of cancer and further provides support for immunotherapeutic strategies that target aberrant O-glycans.
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Metadata
- Authors
- Radhakrishnan, P., Dabelsteen, S., Madsen, F. B., Francavilla, C., Kopp, K. L., Steentoft, C., Vakhrushev, S. Y., Olsen, J. V., Hansen, L., Bennett, E. P., Woetmann, A., Yin, G., Chen, L., Song, H., Bak, M., Hlady, R. A., Peters, S. L., Opavsky, R., Thode, C., Qvortrup, K., Schjoldager, K. T.-B. G., Clausen, H., Hollingsworth, M. A., & Wandall, H. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-08-12
- Volume
- 111
- Issue
- 39
- Pages
- E4066-75
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2075253368
- Cited by
- 313
- References
- 65
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Radhakrishnan, P., Dabelsteen, S., Madsen, F. B., Francavilla, C., Kopp, K. L., Steentoft, C., Vakhrushev, S. Y., Olsen, J. V., Hansen, L., Bennett, E. P., Woetmann, A., Yin, G., Chen, L., Song, H., Bak, M., Hlady, R. A., Peters, S. L., Opavsky, R., Thode, C., . . . Wandall, H. H. (2014). Immature truncated O-glycophenotype of cancer directly induces oncogenic features. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1406619111
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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