The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion
Open accessAbstract
Significance: Beyond its canonical functions in processes such as cell-cycle arrest, apoptosis, and senescence, the tumor suppressor p53 has been increasingly implicated in metabolism. Here, in vitro and in vivo studies establish a role for p53 in gluconeogenesis through a previously unidentified mechanism involving (i) direct activation of the gene encoding the NAD-dependent deacetylase sirtuin 6 (SIRT6), (ii) SIRT6-dependent deacetylation and nuclear exclusion of forkhead box protein O1 (FoxO1), and (iii) down-regulation of FoxO1-activated genes (G6PC and PCK1) that are rate-limiting for gluconeogenesis. These results have implications for proposed tumor-suppressor functions of p53 through regulation of metabolic pathways.
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Cites
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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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“More recently, context-dependent inhibitory (6) or stimulatory (7, 8) effects of p53 on gluconeogenesis have been reported.”
BackgroundResultInfluentialThe sirtuin SIRT6 regulates lifespan in male mice
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SIRT6 Promotes DNA Repair Under Stress by Activating PARP1
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Glycolytic Enzymes Can Modulate Cellular Life Span
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Cited by
P53 in survival, death and metabolic health: a lifeguard with a licence to kill.
Kruiswijk, F., Labuschagne, C. F., & Vousden, K. H. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4007 · Cited by 1,080
Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence
Rajman, L., Chwalek, K., & Sinclair, D. A. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.011 · Cited by 865
Insulin regulation of gluconeogenesis
Hatting, M., Tavares, C. D. J., Sharabi, K., Rines, A. K., & Puigserver, P. (2018) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13435 · Cited by 587
Lacroix, M., Riscal, R., Arena, G., Linares, L. K., & Le Cam, L. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2019.10.002 · Cited by 373
Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase
Wang, Z., & Dong, C. (2019) · Trends in Cancer · doi:10.1016/j.trecan.2018.11.003 · Cited by 293
Metadata
- Authors
- Zhang, P., Tu, B., Wang, H., Cao, Z., Tang, M., Zhang, C., Gu, B., Li, Z., Wang, L., Yang, Y., Zhao, Y., Wang, H., Luo, J., Deng, C.-X., Gao, B., Roeder, R. G., & Zhu, W.-G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2014-07-09
- Volume
- 111
- Issue
- 29
- Pages
- 10684-10689
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2166613336
- Cited by
- 224
- References
- 12
- FWCI
- 8.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Zhang, P., Tu, B., Wang, H., Cao, Z., Tang, M., Zhang, C., Gu, B., Li, Z., Wang, L., Yang, Y., Zhao, Y., Wang, H., Luo, J., Deng, C.-X., Gao, B., Roeder, R. G., & Zhu, W.-G. (2014). Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1411026111
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